Abstract:
:A 1-week treatment with the hepatocarcinogen beta-blocker DL-1-(2-nitro-3-methyl-phenoxy)-3-tert-butylamino-propan-2-ol (ZAMI 1305) induces the appearance of preneoplastic liver lesions--oval cell hyperplasia, basophilic and gamma-glutamyltranspeptidase positive (GGT+) foci--in female Wistar rats, as evidenced by the Solt and Farber short-term test of carcinogenesis. ZAMI 1305-treatment also induces liver DNA damage, as evaluated by alkaline sucrose gradient analysis. The data suggest that the oncogenic B-blocker ZAMI 1305 has initiating activity in the liver of the female Wistar rat.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Zavanella T,Presta M,Braga G,Dimito E,Mazzocchi C,Ziliani S,Ragnotti Gdoi
10.1016/s0304-3835(84)80019-1subject
Has Abstractpub_date
1984-11-01 00:00:00pages
1-11issue
1eissn
0304-3835issn
1872-7980pii
S0304-3835(84)80019-1journal_volume
25pub_type
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