Insulin-like growth factor binding protein-3 inhibits migration of endometrial cancer cells.

Abstract:

:Cell migration and invasion leading to metastasis is a major cause of death from endometrial cancer (EC). We have shown that the rate of EC cell migration is inversely related to the level of insulin-like growth factor protein-3 (IGFBP-3). Down-regulation of IGFBP-3 by siRNA in EC cells accelerated migration without affecting proliferation and cells displayed a more migratory phenotype, with co-localization of migration-associated markers at the leading edge of cell membranes. Opposite effects were seen with either the addition of recombinant IGFBP-3 or overexpression of IGFBP-3. Cells with mutated PTEN had the highest IGFBP-3 expression and the slowest migration rates. This study demonstrates that endogenous IGFBP-3 modulates adhesion-migration dynamics in EC cells, implying that it may be important in regulating metastasis in this disease.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Gribben L,Baxter RC,Marsh DJ

doi

10.1016/j.canlet.2011.11.011

subject

Has Abstract

pub_date

2012-04-01 00:00:00

pages

41-8

issue

1

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(11)00689-6

journal_volume

317

pub_type

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