Abstract:
:Cell migration and invasion leading to metastasis is a major cause of death from endometrial cancer (EC). We have shown that the rate of EC cell migration is inversely related to the level of insulin-like growth factor protein-3 (IGFBP-3). Down-regulation of IGFBP-3 by siRNA in EC cells accelerated migration without affecting proliferation and cells displayed a more migratory phenotype, with co-localization of migration-associated markers at the leading edge of cell membranes. Opposite effects were seen with either the addition of recombinant IGFBP-3 or overexpression of IGFBP-3. Cells with mutated PTEN had the highest IGFBP-3 expression and the slowest migration rates. This study demonstrates that endogenous IGFBP-3 modulates adhesion-migration dynamics in EC cells, implying that it may be important in regulating metastasis in this disease.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Gribben L,Baxter RC,Marsh DJdoi
10.1016/j.canlet.2011.11.011subject
Has Abstractpub_date
2012-04-01 00:00:00pages
41-8issue
1eissn
0304-3835issn
1872-7980pii
S0304-3835(11)00689-6journal_volume
317pub_type
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