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N-Acetylcysteine interacts with copper to generate hydrogen peroxide and selectively induce cancer cell death.

Abstract：

:A variety of metal-binding compounds have been found to exert anti-cancer activity. We postulated that N-acetylcysteine (NAC), which is a membrane-permeable metal-binding compound, might have anti-cancer activity in the presence of metals. We found that NAC/Cu(II) significantly alters growth and induces apoptosis in human cancer lines, yet NAC/Zn(II) and NAC/Fe(III) do not. We further confirmed that this cytotoxicity of NAC/Cu(II) is attributed to reactive oxygen species (ROS). These findings indicate that the combination of Cu(II) and thiols generates cytotoxic ROS that induce apoptosis in cancer cells. They also indicate a fourth class of anti-neoplastic metal-binding compounds, the "ROS generators".

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Zheng J,Lou JR,Zhang XX,Benbrook DM,Hanigan MH,Lind SE,Ding WQ

doi

10.1016/j.canlet.2010.07.003

subject

Has Abstract

pub_date

2010-12-08 00:00:00

pages

186-94

issue

2

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(10)00340-X

journal_volume

298

pub_type

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