Abstract:
:Rats bearing mammary carcinomas induced by N-nitroso-N-methylurea (NMU) were subjected to either no treatment (C), to ovariectomy (O), to continuous ketoconazole dosing at 400 ppm into the diet (K) or to both ovariectomy and ketoconazole dosing (O + K). In both C and K groups survival over the experimental period of 15 weeks was low (12.5% and 15.8%, respectively). In the O group and the O + K group survival markedly improved (52.6%, P less than 0.05 and 68.4%, P less than 0.01, respectively) and partial or complete tumor regression was noted respectively in 2 and 8 rats out of 19. Whereas C and K dosed groups showed an equally high tumor multiplicity and fast tumor growth, both parameters were markedly reduced in the O group and more markedly reduced in the O + K group which showed an overall decrease of the number of tumors. These findings indicate a synergistic effect of ketoconazole dosing and ovariectomy.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
van Cauteren H,van den Berghe J,Hérin V,de Coster R,Marsboom Rdoi
10.1016/0304-3835(84)90136-8subject
Has Abstractpub_date
1984-09-01 00:00:00pages
193-200issue
2eissn
0304-3835issn
1872-7980pii
0304-3835(84)90136-8journal_volume
24pub_type
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