Abstract：
:During the late period of pregnancy (on the 50th and 53rd days post coitum) 2 dogs were injected intraperitoneally with 100 mg/kg (a single administration) of nitrosoethylurea. Nine puppies were born. During the 9 year period of observation no tumours were detected in mother-dogs. Three of 9 offspring developed the following tumours: brain haemangioblastoma (on the 526th day after administration), nephroblastoma and spleen angioleiomyoma (on the 845th day after administration) and adenoma of thyroid gland (after 7 years). Among other lesions 3 offspring-dogs developed polycystic kidneys. The revealed tumours of brain, kidney and spleen could be connected with transplacental carcinogenic effect of N-nitrosoethylurea (NEU), while neoplasms of these localizations and types rarely occur in dogs spontaneously.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Napalkov NP,Alexandrov VA,Anisimov VNdoi
10.1016/0304-3835(81)90052-5subject
Has Abstractpub_date
1981-03-01 00:00:00pages
161-7issue
1-2eissn
0304-3835issn
1872-7980pii
0304-3835(81)90052-5journal_volume
12pub_type
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