CD100-plexin-B1 induces epithelial-mesenchymal transition of head and neck squamous cell carcinoma and promotes metastasis.

abstract：:Indomethacin is a non-steroidal anti-inflammatory agent that inhibits prostaglandin synthesis. Administration of indomethacin, in doses which were non-toxic to normal BALB/c mice, to mice bearing the BCL1 leukemia resulted in increased mortality of these animals. This effect was only observed if the indomethacin was a...

journal_title：Cancer letters

authors： Hart DA

更新日期：1984-06-01 00:00:00

abstract：:Pretreatment of EMT-6 murine tumor cells for 24 h with 10(-4) M 8-methoxypsoralen (8-MOP) increased the photocytotoxicity of Photofrin II (P2) after cell exposure to low doses (1-1.5 J/cm2) of UVA by two- to three-fold. 8-MOP alone had no cytotoxic action under these experimental conditions and did not significantly c...

journal_title：Cancer letters

authors： Sousa C,Mazière C,Melo TS,Vincent-Fiquet O,Rogez JC,Santus R,Mazière JC

更新日期：1998-06-19 00:00:00

abstract：:Photodynamic action has been advocated as an alternative treatment of tumors but the most common used dyes, hematoporphyrin derivatives, are substrate for P-glycoprotein. This study investigated the MDR-reverting properties of methylene blue (MB) and compared the sensitivity to its photodynamic action (PDA) in five ce...

journal_title：Cancer letters

authors： Trindade GS,Farias SL,Rumjanek VM,Capella MA

更新日期：2000-04-14 00:00:00

abstract：:Medroxyprogesterone acetate (MPA) is currently used therapeutically in the treatment of mammary and endometrial carcinomas. In order to develop a more potent and useful drug, we synthesized the novel compound, 9alpha-fluoromedoroxyprogesterone acetate (FMPA), by fluorinating MPA, and we also previously reported that F...

journal_title：Cancer letters

authors： Uchida M,Tsuboi H,Yamaji T,Murata N,Kohno T,Sugino E,Hibino S,Shimamura M,Oikawa T

更新日期：2000-06-01 00:00:00

abstract：:Human PRL-1, PRL-2, and PRL-3 tyrosine phosphatases induce the malignant transformation of epithelial cells. We tested the hypothesis that the oncogenic effects of PRL occur by increasing cellular proliferation. Cells stably transfected with PRL-1 or PRL-2 exhibited 2.7-3.3-fold increases over control cells in the rat...

journal_title：Cancer letters

authors： Werner SR,Lee PA,DeCamp MW,Crowell DN,Randall SK,Crowell PL

更新日期：2003-12-30 00:00:00

abstract：:Since CP always exists in aqueous solution as a mixture of native drug and various aqua and hydroxo species, it is conceivable that one or more of these aquated species is the main form of the drug that enters the cell. To test this hypothesis, we examined the accumulation by 2008 human ovarian carcinoma cells of CP a...

journal_title：Cancer letters

authors： Jennerwein M,Andrews PA

更新日期：1994-06-30 00:00:00

abstract：:Invasion process occurs both in mammalian embryo implantation during development and malignant cancer cell metastasis. We investigated the interactions between trophoblasts and metastatic cancer cells and found the phenomenon that mouse trophoblastic cells invaded the monolayer of malignant cancer cells in vitro and a...

journal_title：Cancer letters

authors： Fang LQ,Zhang H,Ding XY,Li DQ,Hou XL,Qiao H,Bai J,Wang ZB

更新日期：2010-12-28 00:00:00

abstract：:Despite the common expression of death receptors, many types of cancer including gliomas are resistant to the death receptor ligand (TRAIL). Melatonin antitumoral actions have been extensively described, including oncostatic properties on several tumor types and improvement of chemotherapeutic regimens. Here, we found...

journal_title：Cancer letters

authors： Martín V,García-Santos G,Rodriguez-Blanco J,Casado-Zapico S,Sanchez-Sanchez A,Antolín I,Medina M,Rodriguez C

更新日期：2010-01-28 00:00:00

abstract：:The in vitro sensitivities to differentiating agents of a murine neuroblastoma cell line (N18) and a selected variant cell line (N18-LM5) were examined. In addition, the sensitivities to differentiating agents of cells from spontaneous metastases produced by N18 cells were examined. When N18 cells (1 X 10(5) cells/mou...

journal_title：Cancer letters

authors： Takenaga K

更新日期：1983-05-01 00:00:00

abstract：:Cancer stem cells (CSC) are critical for initiation, metastasis, and relapse of cancers, however, the underlying mechanism governing stemness of CSC remains unknown. Herein, we have investigated the roles of phosphodiesterase 5 (PDE5) in stemness of prostate cancer cells. Both PDE5 and WW domain-containing transcripti...

journal_title：Cancer letters

authors： Liu N,Mei L,Fan X,Tang C,Ji X,Hu X,Shi W,Qian Y,Hussain M,Wu J,Wang C,Lin S,Wu X

更新日期：2016-08-01 00:00:00

abstract：:Rats bearing mammary carcinomas induced by N-nitroso-N-methylurea (NMU) were subjected to either no treatment (C), to ovariectomy (O), to continuous ketoconazole dosing at 400 ppm into the diet (K) or to both ovariectomy and ketoconazole dosing (O + K). In both C and K groups survival over the experimental period of 1...

journal_title：Cancer letters

authors： van Cauteren H,van den Berghe J,Hérin V,de Coster R,Marsboom R

更新日期：1984-09-01 00:00:00

abstract：:It has been nearly 9years since the FDA (Food and Drug Administration) approved the first anti-angiogenic drug (bevacizumab) for treatment of metastatic colorectal cancer. Other angiogenic inhibitors have since been approved or are in different stages of clinical trials. However, continued clinical and preclinical inv...

journal_title：Cancer letters

authors： Shojaei F

更新日期：2012-07-28 00:00:00

abstract：:TGF-β signaling plays an important role in breast cancer progression and metastasis. Epithelial-mesenchymal transition (EMT) is an important step in the progression of solid tumors to metastatic disease. We previously reported that IN-1130, a novel transforming growth factor-β type I receptor kinase (ALK5) inhibitor, ...

journal_title：Cancer letters

authors： Park CY,Min KN,Son JY,Park SY,Nam JS,Kim DK,Sheen YY

更新日期：2014-08-28 00:00:00

abstract：:We have developed a simple system for rapid detection and measurement of glutathione S-transferase placental form (GSTP1) that detoxify polycyclic aromatic hydrocarbons using the cultured rat normal liver epithelial cell line, (RL34) cells. Survey of fruit extracts for GST inducing ability identified both papaya and a...

journal_title：Cancer letters

authors： Nakamura Y,Morimitsu Y,Uzu T,Ohigashi H,Murakami A,Naito Y,Nakagawa Y,Osawa T,Uchida K

更新日期：2000-09-01 00:00:00

abstract：:In vitro cytotoxicity tests currently in use applied in the developmental stages of anticancer drug discovery are able to select the most potent compounds, but are not predictive of their potential toxicity. In this study, we have demonstrated the applicability of neutral red uptake assay using mouse fibroblasts Balb/...

journal_title：Cancer letters

authors： Popiołkiewicz J,Polkowski K,Skierski JS,Mazurek AP

更新日期：2005-11-08 00:00:00

abstract：:A panel of clinically used tyrosine kinase inhibitors were compared and nilotinib was found to most potently sensitize specific anticancer agents by blocking the functions of ABCB1/P-glycoprotein, ABCG2/BCRP and ABCC10/MRP7 transporters involved in multi-drug resistance. Nilotinib appreciably enhanced the antitumor re...

journal_title：Cancer letters

authors： Tiwari AK,Sodani K,Dai CL,Abuznait AH,Singh S,Xiao ZJ,Patel A,Talele TT,Fu L,Kaddoumi A,Gallo JM,Chen ZS

更新日期：2013-01-28 00:00:00

abstract：:Ritalin (methylphenidate hydrochloride), Benzedrine (amphetamine sulfate), and Dexedrine (dextroamphetamine sulfate) were examined for oncogenicity using a serial line of Fischer rat embryo cells, which was previously shown to be a sensitive and accurate indicator of chemicals carcinogenic for rodents. At the concentr...

journal_title：Cancer letters

authors： Price PJ,Gregory EA,Skeen PC

更新日期：1978-12-01 00:00:00

abstract：:Bile acids are promoters of colon cancer; however, the mechanism(s) of action of this tumor promoter are largely unknown. Bile acids induce apoptosis in colon epithelial cells and it is probable that the modulation of apoptosis contributes, in part, to colon carcinogenesis. We tested the hypothesis that damage to mito...

journal_title：Cancer letters

authors： Washo-Stultz D,Crowley-Weber CL,Dvorakova K,Bernstein C,Bernstein H,Kunke K,Waltmire CN,Garewal H,Payne CM

更新日期：2002-03-28 00:00:00

abstract：:Serum alpha-N-acetylgalactosaminidase (NaGalase) is responsible for the deglycosylation of vitamin D(3)-binding protein (Gc protein). The deglycosylated Gc protein cannot be converted into major macrophage-activating factor (MAF), leading to immunosuppression. NaGalase is universally detected in a variety of cancer pa...

journal_title：Cancer letters

authors： Reddi AL,Sankaranarayanan K,Arulraj HS,Devaraj N,Devaraj H

更新日期：2000-09-29 00:00:00

abstract：:Post-transplant lymphoproliferative disorders (PTLDs) represent the most severe complication of both solid organ and hematopoietic stem cell transplantation. The Epstein-Barr Virus (EBV) is the main driver of PTLD, particularly those occurring early after transplantation. EBV-driven malignancies are associated with se...

journal_title：Cancer letters

authors： Petrara MR,Giunco S,Serraino D,Dolcetti R,De Rossi A

更新日期：2015-12-01 00:00:00

abstract：:Chronic exposure to cadmium is known to be a risk factor for human prostate cancer. Despite over-whelming evidence of cadmium causing carcinogenicity in humans, the specific underlying molecular mechanisms that govern metal-induced cellular transformation remain unclear. Acute exposure (up to 72 h) to cadmium induces ...

journal_title：Cancer letters

authors： Kolluru V,Pal D,Papu John AMS,Ankem MK,Freedman JH,Damodaran C

更新日期：2017-11-01 00:00:00

abstract：:In our joint project in the search for anti-tumor promoters from natural plant sources, we carried out a primary screening of 12 phenylpropanoids isolated from Boronia pinnata Sm. (Rutaceae) by examining their possible inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradeca...

journal_title：Cancer letters

authors： Ito C,Itoigawa M,Furukawa H,Ichiishi E,Mukainaka T,Okuda M,Ogata M,Tokuda H,Nishino H

更新日期：1999-07-19 00:00:00

abstract：:Radiation therapy has become an important tool in the treatment of cancer patients, but most patients relapse within 5 years. Relapse is due to the presence of cancer stem cells (CSCs), but the molecular mechanism of radioresistance in CSCs remains largely elusive. Here, we found that irradiation-resistant (IR) cells ...

journal_title：Cancer letters

authors： Shi Y,Liu N,Lai W,Yan B,Chen L,Liu S,Liu S,Wang X,Xiao D,Liu X,Mao C,Jiang Y,Jia J,Liu Y,Yang R,Cao Y,Tao Y

更新日期：2018-05-28 00:00:00

abstract：:We investigated the mechanisms of action and antitumor effects of OPB-31121, a novel STAT3 inhibitor, in gastric cancer cells. OPB-31121 downregulated JAK2 and gp130 expression and inhibited JAK2 phosphorylation which leads to inhibition of STAT3 phosphorylation. OPB-31121 inhibited constitutively activated and IL-6-i...

journal_title：Cancer letters

authors： Kim MJ,Nam HJ,Kim HP,Han SW,Im SA,Kim TY,Oh DY,Bang YJ

更新日期：2013-07-10 00:00:00

abstract：:The three mistletoe (Viscum album L.) lectins. ML I, ML II and ML III, were tested on their ability to enhance the secretion of the cytokines tumor necrosis factor (TNF)alpha, interleukin (IL)-1 alpha, IL-1 beta and IL-6 by human monocytes obtained from healthy donors. At lectin concentrations from 0.02 to 20/pg ml (1...

journal_title：Cancer letters

authors： Ribéreau-Gayon G,Dumont S,Muller C,Jung ML,Poindron P,Anton R

更新日期：1996-12-03 00:00:00

abstract：:Targeting specific tumor metabolic needs represents an actively investigated therapeutic strategy to bypass tumor resistance mechanisms. In this study, we describe an original approach to impact the cancer metabolism by exploiting the redox properties of a ruthenium organometallic compound. This organometallic complex...

journal_title：Cancer letters

authors： Vidimar V,Licona C,Cerón-Camacho R,Guerin E,Coliat P,Venkatasamy A,Ali M,Guenot D,Le Lagadec R,Jung AC,Freund JN,Pfeffer M,Mellitzer G,Sava G,Gaiddon C

更新日期：2019-01-01 00:00:00

abstract：:gamma-Glutamyltranspeptidase (gamma-GTP) activity was found in a human pancreatic cancer cell line, HPC-Y1, cultivated in a serum-free chemically defined medium. The gamma-GTP stained in the cytoplasms as fine granules and was produced constantly in a protein-free chemically defined medium. The detergent- or protease-...

journal_title：Cancer letters

authors： Yamaguchi N,Sugimoto M,Kawai K

更新日期：1984-12-01 00:00:00

abstract：:Staurosporine (ST), a potent inhibitor of protein kinase C (PKC), was evaluated for its effect on the proliferation of HT-29 colon adenocarcinoma cells; PKC is associated with increased colon cell proliferation. ST inhibited cell proliferation in a time- and concentration-dependent manner by up to 90%. It also blocked...

journal_title：Cancer letters

authors： Qiao L,Koutsos M,Tsai LL,Kozoni V,Guzman J,Shiff SJ,Rigas B

更新日期：1996-10-01 00:00:00

abstract：:The fruiting body of Antrodia camphorata is well known in Taiwan as a traditional medicine for treating cancer and inflammation. The purpose of this study was to evaluate the apoptotic effects of ethylacetate extract from A. camphorata (EAC) fruiting bodies in two human liver cancer cell lines, Hep G2 and PLC/PRF/5. T...

journal_title：Cancer letters

authors： Hsu YL,Kuo YC,Kuo PL,Ng LT,Kuo YH,Lin CC

更新日期：2005-04-18 00:00:00

abstract：:Non-steroidal anti-inflammatory drugs (NSAIDs) have been shown to reduce the risk of colorectal cancer (CRC). They are also known to induce the regression of colorectal adenomas, which are precursors to CRC. Despite these evidences, the exact mechanism by which NSAIDs exerts its anti-oncogenic effect is not completely...

journal_title：Cancer letters

authors： Gala M,Sun R,Yang VW

更新日期：2002-01-10 00:00:00