Abstract：
:Invasion process occurs both in mammalian embryo implantation during development and malignant cancer cell metastasis. We investigated the interactions between trophoblasts and metastatic cancer cells and found the phenomenon that mouse trophoblastic cells invaded the monolayer of malignant cancer cells in vitro and appeared the general trait of invasiveness to more than 30 types of malignant cancer cell lines which were derived from different histological origins and with different invasive or metastatic potential. We further investigated the cellular and molecular changes in the process of mouse trophoblastic cells invading human ovarian cancer HO-8910 cells. The results show that the invasion of trophoblastic cells lead HO-8910 cells near mouse embryo to apoptosis, and expression of cell-cycle-related protein cyclinD1 and Ki-67 mRNA were steadily remained both in mouse blastocysts and human ovarian cancer HO-8910 cells, which in part explain the proliferation activities of these cells. Our study also shows that expression of some proteins including MMP-9, FAK and Integrinαvβ3 was changeable in trophoblastic cells and HO-8910 cells in the process of blastocyst invasion, which suggested temporal expression of these molecules may involved in the invasive behavior of trophoblasts cells to cancer cells.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Fang LQ,Zhang H,Ding XY,Li DQ,Hou XL,Qiao H,Bai J,Wang ZBdoi
10.1016/j.canlet.2010.08.008subject
Has Abstractpub_date
2010-12-28 00:00:00pages
111-8issue
2eissn
0304-3835issn
1872-7980pii
S0304-3835(10)00389-7journal_volume
299pub_type
杂志文章相关文献
CANCER LETTERS文献大全abstract：:Hyperproliferation of rectal epithelium is characteristic of families at high genetic risk for large bowel neoplasia, but has not been well-documented in families of sporadic colorectal cancer patients. This was studied in 119 such first degree relatives and 44 comparison subjects without this family history. All scre...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(90)90047-2
更新日期：1990-05-30 00:00:00
abstract：:In order to understand the differences and similarities between tumorigenic and non-tumorigenic HeLaxhuman fibroblast hybrids, gene expression profiles were examined with synthetic oligonucleotide arrays containing nearly 7000 gene probe sets. We used two pairs of genetically related hybrids, each pair representing in...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(01)00437-2
更新日期：2001-04-26 00:00:00
abstract：:2-Amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine (PhIP) is known to induce colon tumors in male Fischer-344 rats. Using 32P-postlabeling assays, we have examined PhIP-DNA adduct formation in various organs and white blood cells (WBCs) of the male Fischer-344 rat 24 h after a single oral dose of 0, 0.5, 5 or 50 mg PhIP...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(92)90134-h
更新日期：1992-12-24 00:00:00
abstract：:Specific [3H]fucose-labeled glycoproteins were found in the serum of rats bearing Zajdela hepatoma, which possess different isoelectric points in comparison with serum glycoproteins from normal rats. The electrophoretic profile of the serum glycoproteins is significantly altered. There is approximately a 2.5 times inc...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(97)00524-7
更新日期：1998-03-13 00:00:00
abstract：:BRCA1 and BRCA2 genes were screened for loss-of-function mutations in a series of 85 patients having at least one first- or second-degree relative affected by breast and/or ovarian cancer. All BRCA1 exons and BRCA2 exons 10 and 11 were screened with a combination of methods including SSCP, PTT and direct sequencing. W...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(01)00845-x
更新日期：2002-11-08 00:00:00
abstract：:Metastasis is a characteristic and fatal feature of human malignancies. Its regulation is therefore of the utmost significance to clinicians. The present study was undertaken to determine whether a legume-derived protease inhibitor (PI) of trypsin/chymotrypsin, the field bean PI (FBPI), also has plasmin inhibitory act...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(98)00090-1
更新日期：1998-07-03 00:00:00
abstract：:Third generation bisphosphonates (BPs), including YM175 and YM529, are known to inhibit bone resorption. The aim of this study was to evaluate the anti-tumor effects of these drugs on murine osteosarcoma cell lines, in terms of proliferation and apoptosis. We found that both YM175 and YM529 strongly inhibited the in v...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2005.06.041
更新日期：2006-07-08 00:00:00
abstract：:During the late period of pregnancy (on the 50th and 53rd days post coitum) 2 dogs were injected intraperitoneally with 100 mg/kg (a single administration) of nitrosoethylurea. Nine puppies were born. During the 9 year period of observation no tumours were detected in mother-dogs. Three of 9 offspring developed the fo...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(81)90052-5
更新日期：1981-03-01 00:00:00
abstract：:Primary liver cancer is the fifth most common cancer worldwide and hepatocellular carcinoma (HCC) accounts for over 85% of all primary liver cancers. The clinical management of advanced and metastatic HCC is challenging on many counts. Besides largely occurs within a background of underlying chronic liver disease and ...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2008.11.005
更新日期：2009-12-01 00:00:00
abstract：:Effects of cis-dichlorodiammineplatinum-(II) (cis-DDP), an anticancer agent, on capping of membrane receptors were investigated in mouse spleen cells in vitro, using fluorescein labeled ligands. Cap formations of surface immunoglobulin and of concanavalin A receptors were significantly reduced by cis-DDP in relation t...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(80)90079-8
更新日期：1980-09-01 00:00:00
abstract：:Oral treatment with reduced glutathione for 10 weeks has no effect on the development of tumours from aflatoxin B1-induced gamma-glutamyl transpeptidase-positive pre-neoplastic focal lesions. ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(83)90086-1
更新日期：1983-11-01 00:00:00
abstract：:CD95, TNFR1, TRAILR1 and TRAILR2 belong to a subgroup of TNF receptors which is characterized by a conserved cell death-inducing protein domain that connects these receptors to the apoptotic machinery of the cell. Activation of death receptors in malignant cells attracts increasing attention as a principle to fight ca...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2010.12.019
更新日期：2013-05-28 00:00:00
abstract：:The B cell lymphomas associated with Epstein-Barr virus (EBV) are not limited to any specific stage of B cell differentiation but covers widely different B cell phenotypes. In vitro infection of the virus negative tumors with a recombinant EBV strain has provided important insights into virus-tumor interaction. Here, ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2009.04.025
更新日期：2009-11-01 00:00:00
abstract：:A retroviral vector carrying herpes simplex virus thymidine kinase (HSV-TK) gene was introduced into psi 2 packaging cells (psi 2tkn) and XC tumor cells (XCtkn). psi 2tkn, XCtkn and XC cells co-cultured with TK-carrying cells were killed by ganciclovir (GCV) treatment. The growth of XC cells transplanted into nude mic...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(96)04260-7
更新日期：1996-07-19 00:00:00
abstract：:The present study was conducted to investigate protein levels of inducible NO synthase (iNOS) and cayclooxygenase-2 (COX-2) in human colon cancer tissues. Significant increase of iNOS and COX-2 levels in tumors as compared to paired normal tissue was observed in 15 and 28, respectively, of 29 cases investigated. No co...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2005.08.014
更新日期：2006-08-08 00:00:00
abstract：:Major cytotoxic components were fractionated from Korean mistletoe and the changes of their cytotoxic effects caused by heat treatment were investigated. The high cytotoxicity of isolated lectin I completely disappeared by heating for 30 min. The fractions of viscotoxins and alkaloids maintained their activities even ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(99)00043-9
更新日期：1999-05-24 00:00:00
abstract：:The p53 tumor suppressor gene is often mutated in various human cancers. Recently, the p53 codon 72 polymorphism has been extensively studied to determine the risk factors responsible for cancer formation. We investigated the genotype distribution of the p53 codon 72 polymorphism in 112 male urothelial cancer cases an...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(02)00518-9
更新日期：2003-01-10 00:00:00
abstract：:Cancer results from the interaction of multiple aberrations including activation of dominant oncogenes and upregulation of signal transduction pathways. Identification of the genes involved in malignant transformation is a pre-requisite for understanding cancer and improving its diagnosis and treatment. Quite a few of...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2007.04.015
更新日期：2007-10-08 00:00:00
abstract：:Endostatin has been demonstrated to represent a promising novel medicine to treat malignant tumors, and it may be more effective when combined with conventional treatment. Meanwhile, a promising area of research in radiation oncology is the integration of molecular targeting agents to improve the effectiveness of radi...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2008.12.008
更新日期：2009-09-08 00:00:00
abstract：:In this study, we investigated the anticancer efficacy of pegylated liposomes containing 6BrCaQ, an hsp90 inhibitor derived from novobiocin. 6BrCaQ has been previously identified as the most potent compound in a series of quinoleic novobiocin analogs but is poorly water-soluble. We investigated, for the first time, th...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2018.06.001
更新日期：2018-09-28 00:00:00
abstract：:The vectors PAI2, C595 and Herceptin target the membrane-bound uPA, MUC1 and HER2 antigens expressed by cancer cells, respectively. The expression of these receptors was tested in the ovarian cancer cell line OVCAR-3; MUC-1 was strongly expressed (3+), uPA moderately expressed (2+), but HER2 was negative (-). The alph...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2005.03.060
更新日期：2006-03-28 00:00:00
abstract：:Agents antagonizing the anti-apoptotic Bcl-2 protein have been shown to restore normal apoptotic processes in cancer cells. Since upregulation of Bcl-2 is often observed in recurrent or refractory hematological malignancies, we were prompted to investigate whether drug-selected leukemia cells overexpressing Bcl-2 were...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2007.01.018
更新日期：2007-08-08 00:00:00
abstract：:The antitumor effects of 2'-C-cyano-2'-deoxy-1-beta-D- arabinofuranosylcytosine (CN-DAC), a synthetic 1-beta-D-arabinofuranosyl-cytosine (ara-C) derivative, were examined and compared with that of ara-C in murine tumors and in various human tumors using three different chemosensitivity tests. CNDAC extended the life s...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(92)90024-p
更新日期：1992-05-30 00:00:00
abstract：:Bevacizumab (Avastin®, Genentech, CA) was granted accelerated approval by the FDA for metastatic breast cancer in 2008. This occurred after the initial clinical trial, E2100, demonstrated an improvement in progression-free survival (PFS) and overall survival (OS) with the addition of bevacizumab to a standard chemothe...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2014.10.028
更新日期：2015-02-01 00:00:00
abstract：:Cucurbitacin B is a natural anti-cancer compound found in Cucurbitaceae. Although the anti-cancer activity of cucurbitacin B in human leukemia cells has been reported, the underlining mechanism is still unclear. To clarify its anti-cancer activity and the mechanism of action, five different leukemia cell lines (CCRF-C...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2009.07.015
更新日期：2010-03-01 00:00:00
abstract：:A rabbit gamma delta killer T-cell line against Shope carcinoma cells was established from peripheral blood lymphocytes (PBL) of a human T-lymphotropic virus type I (HTLV-I)-infected rabbit bearing Shope papilloma and carcinoma. Southern hybridization analysis of this cell line with an HTLV-I probe showed that the cel...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(95)90155-8
更新日期：1995-02-10 00:00:00
abstract：:Gene-silencing with targeted siRNAs has great potential as a therapeutic approach for various diseases including cancer. However, intracellular delivery of siRNA is challenging. We used bovine milk exosomes as a novel system for siRNA delivery. First, we demonstrated that exosomes can deliver endogenous RNA payloads i...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2019.02.011
更新日期：2019-05-01 00:00:00
abstract：:Hypusine formation on the eukaryotic initiation factor 5A (eIF-5A) precursor is ubiquitously present in eukaryotic cells and archebacteria. In this reaction, deoxyhypusine synthase catalyzes the conversion of one unique lysine residue on eIF-5A to deoxyhypusine using spermidine as the substrate. Hydroxylation of the d...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(97)04741-1
更新日期：1997-05-19 00:00:00
abstract：:Interleukin-2 (IL-2) and granulocyte-macrophage colony stimulating factor (GM-CSF) facilitate the maturation and functioning of injected DC. We developed a method of in situ electroporation using IL-2 and GM-CSF genes (EGT/cytokines), followed by intra-tumoral (i.t.) immature DC to determine the immune response at the...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2008.02.063
更新日期：2008-08-08 00:00:00
abstract：:(-)-Epigallocatechin gallate (EGCG), a major constituent of green tea, has been shown to exhibit anti-cancer activity. Sulindac is also well known as a cancer-preventive agent against colon cancer, but its usage is restricted because of its adverse effects, as exemplified by gastrointestinal bleeding. In the present s...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(01)00767-4
更新日期：2002-03-08 00:00:00
