Cucurbitacin B inhibits STAT3 and the Raf/MEK/ERK pathway in leukemia cell line K562.

abstract：:Conventional chemotherapies have some limitations, including the lack of selectivity, high toxicity to normal tissues, multidrug resistance, and tumor relapse. Recently, great progress was made in immunotherapies for anticancer research, with bacteria-mediated cancer therapy one of the most promising approaches among ...

journal_title：Cancer letters

authors： Guo Y,Chen Y,Liu X,Min JJ,Tan W,Zheng JH

更新日期：2020-01-28 00:00:00

abstract：:Previously, we had reviewed 43 cases of invasive cancers, adenosquamous cell carcinoma and adenocarcinoma for HPV type infections. With the same cases we extended the investigation to cytomegalovirus (CMV) and herpes simplex virus (HSV) infections. Results show that the prevalence of CMV and HSV infections from these ...

journal_title：Cancer letters

authors： Han CP,Tsao YP,Sun CA,Ng HT,Chen SL

更新日期：1997-12-09 00:00:00

abstract：:Very few studies have been reported the function of wild type IDH1 in tumor progress. Previously, we reported that IDH1 correlated with pathological grade and metastatic potential inversely in human osteosarcoma. Here, IDH1 was found lower expressed in osteosarcoma tissues than that of adjacent normal bone tissues. In...

journal_title：Cancer letters

authors： Hu X,Liu Y,Qin C,Pan Z,Luo J,Yu A,Cheng Z

更新日期：2014-04-28 00:00:00

abstract：:Modern protocols of concomitant chemo/radiotherapy provide a very effective strategy to treat certain types of tumors. High-linear energy transfer (LET) radiations, on the other hand, have an increased efficacy against cancer with low radiosensibility and critical localization. We previously reported that oxaliplatin,...

journal_title：Cancer letters

authors： Benzina S,Altmeyer A,Malek F,Dufour P,Denis JM,Gueulette J,Bischoff P

更新日期：2008-06-08 00:00:00

abstract：:We investigated the mechanisms of action and antitumor effects of OPB-31121, a novel STAT3 inhibitor, in gastric cancer cells. OPB-31121 downregulated JAK2 and gp130 expression and inhibited JAK2 phosphorylation which leads to inhibition of STAT3 phosphorylation. OPB-31121 inhibited constitutively activated and IL-6-i...

journal_title：Cancer letters

authors： Kim MJ,Nam HJ,Kim HP,Han SW,Im SA,Kim TY,Oh DY,Bang YJ

更新日期：2013-07-10 00:00:00

abstract：:Many members of BCL2 (Bcl-2) apoptosis-related genes were found to be differentially expressed in various malignancies and were proposed as prognostic cancer biomarkers. Recently, a new member of the BCL2 gene family, BCL2L12, was cloned and was found to be expressed in mammary gland. In the present study, 55 specimen...

journal_title：Cancer letters

authors： Thomadaki H,Talieri M,Scorilas A

更新日期：2007-03-08 00:00:00

abstract：:Samples of human endometrial carcinomas of ranging degree of histological differentiation, and normal endometrial tissues were screened for the presence of single site DNA mutations at codon 12 of the C-K-ras gene using oligonucleotide hybridisation of DNA amplified by the polymerase chain reaction (PCR). Two instance...

journal_title：Cancer letters

authors： Lester DR,Cauchi MN

更新日期：1990-05-15 00:00:00

abstract：:Hyperproliferation of rectal epithelium is characteristic of families at high genetic risk for large bowel neoplasia, but has not been well-documented in families of sporadic colorectal cancer patients. This was studied in 119 such first degree relatives and 44 comparison subjects without this family history. All scre...

journal_title：Cancer letters

authors： Rozen P,Fireman Z,Fine N,Chetrit A,Lubin F

更新日期：1990-05-30 00:00:00

abstract：:Rats bearing the Yoshida AH-130 ascites hepatoma, a cachectic rat tumour, showed signs of important muscle wasting with reduced muscle weights. This phenomenon was associated with a decreased rate of in vivo alanine oxidation as measured by the production of 14CO2 from [U-14C]alanine intragastrically administered. It ...

journal_title：Cancer letters

authors： García-Martínez C,López-Soriano FJ,Argilés JM

更新日期：1994-12-09 00:00:00

abstract：:To date, several kinds of immunomodulating monoclonal antibodies (mAbs) have been applied in clinical trials, such as anti-cytotoxic T-lymphocyte antigen-4 (anti-CTLA-4) mAb and anti-programmed death-1 (anti-PD-1) mAb. With the recent success of cancer immunotherapy, especially the checkpoint inhibitors, the renewed i...

journal_title：Cancer letters

authors： Teng F,Kong L,Meng X,Yang J,Yu J

更新日期：2015-08-28 00:00:00

abstract：:Angiogenesis remains a sensible target for pancreatic ductal adenocarcinoma (PDAC) therapy. VEGF, PDGF, FGF and their receptors are expressed at high levels and correlate with poor prognosis in human PDAC. Nintedanib is a triple angiokinase inhibitor that targets VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β signaling. We invest...

journal_title：Cancer letters

authors： Awasthi N,Hinz S,Brekken RA,Schwarz MA,Schwarz RE

更新日期：2015-03-01 00:00:00

abstract：:In esophageal squamous cell carcinoma (SCC), we used immunohistochemical analysis to further elucidate the correlation of p53 protein expression with clinicopathological factors, as well as with risk factors, such as tobacco smoking, alcohol consumption and a family history of cancer, using odds ratios (ORs). The expr...

journal_title：Cancer letters

authors： Kato H,Yoshikawa M,Miyazaki T,Nakajima M,Fukai Y,Tajima K,Masuda N,Tsukada K,Fukuda T,Nakajima T,Kuwano H

更新日期：2001-06-10 00:00:00

abstract：:The tumorigenicity of 7-chlorobenz[a]anthracene (7-Cl-BA, and environmental contaminant, and 7 bromobenz[a]anthracene (7-Br-BA) was determines in the male B6C3F(1) newborn mouse. Mice receiving 7-Cl-BA and 7-Br-BA by i.p. injections at a dose of 1600 nmol per mouse on 1, 8, and 15 days after birth developed 92 and 96%...

journal_title：Cancer letters

authors： Fu PP,Von Tungeln LS,Zhan DJ,Bucci T

更新日期：1996-03-19 00:00:00

abstract：:In many parts of the world, green tea and black tea are produced from the plant Camellia sinensis. Tea is one of the most widely consumed beverages, second only to water. It is one of the safest beverages since it is made with boiling, sterile water and has been popular for over 4000 years. Dogma has it that people kn...

journal_title：Cancer letters

authors： Weisburger JH

更新日期：1997-03-19 00:00:00

abstract：:The effect of different tannin-containing aqueous solutions on the carcinogenic action of benzo(a)pyrene (BP) on the mouse skin was investigated. It was found that the appearance of tumours was accelerated in mice treated with either tea or an oak extract after a single application of BP. The time of appearance of tum...

journal_title：Cancer letters

authors： Bogovski P,Day N

更新日期：1977-07-01 00:00:00

abstract：:As myeloma cells actively produce and secrete immunoglobulins, they are prone to ER stress, which if unresolved leads to apoptosis. We found that myeloma cell death induced by the ER stressor Thapsigargin was highly variable, ranging from 2 to 89%. Induction of ATF4 and CHOP was observed in myeloma cells under Thapsig...

journal_title：Cancer letters

authors： Gomez-Bougie P,Halliez M,Moreau P,Pellat-Deceunynck C,Amiot M

更新日期：2016-12-28 00:00:00

abstract：:Epidemiological reports suggest that Asians consuming a diet high in soy have a low incidence of clinically manifested prostate cancer. We have tested the hypothesis that life-time exposure to genistein, the primary isoflavone component of soy, is responsible for this protective effect. Lobund-Wistar rats were exposed...

journal_title：Cancer letters

authors： Wang J,Eltoum IE,Lamartiniere CA

更新日期：2002-12-01 00:00:00

abstract：:Diet-induced changes in serum cholesterol levels and their relationship to mammary carcinogenesis initiated by 7,12-dimethylbenz[a]anthracene (DMBA) were studied in female Sprague-Dawley rats. DMBA was given to rats subjected to 3 dietary treatments: (1) a semipurified, cholesterol-free diet (SP); (2) the same diet wi...

journal_title：Cancer letters

authors： Klurfeld DM,Kritchevsky D

更新日期：1981-12-01 00:00:00

abstract：:To shed light on the association of intestinal microflora with the development of colon cancer, we studied the modifying effects of intestinal microflora on the occurrence of 1,2-dimethylhydrazine (DMH)-induced colonic aberrant crypt foci (ACF) in germfree (GF), gnotobiotic (GB) and conventionalized (Cvd) rats. In the...

journal_title：Cancer letters

authors： Onoue M,Kado S,Sakaitani Y,Uchida K,Morotomi M

更新日期：1997-02-26 00:00:00

abstract：:Interferon regulatory factor (IRF1) is a potent antiviral, antitumor and immune regulatory protein. Recently, we found that activated Ras/MEK inhibits antiviral response by downregulating IRF1 expression and renders cancer cells susceptible to oncolytic viruses. In this study, we sought to determine whether IRF1 downr...

journal_title：Cancer letters

authors： AbuSara N,Razavi S,Derwish L,Komatsu Y,Licursi M,Hirasawa K

更新日期：2015-02-28 00:00:00

abstract：:Immunogenic, methylcholanthrene-induced sarcomas failed to elicit the production of rapidly cytolytic T lymphocytes in syngeneic mice, although they did elicit the production of more slowly cytotoxic cells. They were, however, susceptible to attack by cytolytic T cells from allo-immune mice and, if infected with ectro...

journal_title：Cancer letters

authors： Nelson DS,Hopper KE,Blanden RV,Gardner ID,Kearney R

更新日期：1978-08-01 00:00:00

abstract：:Multiple cancers contain subpopulations that exhibit characteristics of cancer stem cells (CSCs), the ability to self-renew and seed heterogeneous tumors. Recent evidence suggests two potentially overlapping models for these phenotypes: one where stem cells arise from multipotent progenitor cells, and another where th...

journal_title：Cancer letters

authors： Chang JT,Mani SA

更新日期：2013-11-28 00:00:00

abstract：:A panel of clinically used tyrosine kinase inhibitors were compared and nilotinib was found to most potently sensitize specific anticancer agents by blocking the functions of ABCB1/P-glycoprotein, ABCG2/BCRP and ABCC10/MRP7 transporters involved in multi-drug resistance. Nilotinib appreciably enhanced the antitumor re...

journal_title：Cancer letters

authors： Tiwari AK,Sodani K,Dai CL,Abuznait AH,Singh S,Xiao ZJ,Patel A,Talele TT,Fu L,Kaddoumi A,Gallo JM,Chen ZS

更新日期：2013-01-28 00:00:00

abstract：:By virtue of being a localized treatment modality, radiotherapy is unable to deliver a tumoricidal radiation dose to tissues outside of the irradiated field. Nevertheless, ionizing radiation may result in radiation damage mediated by a bystander like effect away from the irradiated field, but this response is likely t...

journal_title：Cancer letters

authors： Hanna GG,Coyle VM,Prise KM

更新日期：2015-11-28 00:00:00

abstract：:14-3-3 sigma is a negative regulator of the cell cycle and contributes to G2 arrest. Thus far, the lack of its expression due to hypermethylation of the CpG islands has been reported in some carcinomas. In this study, we investigated the expression of 14-3-3 sigma in thyroid neoplasms by means of immunohistochemistry ...

journal_title：Cancer letters

authors： Ito Y,Miyoshi E,Uda E,Yoshida H,Uruno T,Takamura Y,Miya A,Kobayashi K,Matsuzuka F,Matsuura N,Kakudo K,Kuma K,Miyauchi A

更新日期：2003-10-28 00:00:00

abstract：:Integrin cell adhesion molecules play a crucial role in tumor cell resistance to radio- and chemotherapy and are therefore considered attractive targets for cancer therapy. Here, we assessed the role of β1 integrin-interacting α integrin subunits in more physiological three-dimensional extracellular matrix grown head ...

journal_title：Cancer letters

authors： Steglich A,Vehlow A,Eke I,Cordes N

更新日期：2015-02-28 00:00:00

abstract：:Stem cell factor (SCF) is a multifunctional cytokine responsible for tumorigenesis and progression. In this study, we report that increased expression of SCF in hepatocellular carcinoma (HCC) patients is highly associated with metastasis and poor prognosis. SCF inhibition with RNAi inhibited HCC cell migration, invasi...

journal_title：Cancer letters

authors： Wang X,Dong J,Jia L,Zhao T,Lang M,Li Z,Lan C,Li X,Hao J,Wang H,Qin T,Huang C,Yang S,Yu M,Ren H

更新日期：2017-05-01 00:00:00

abstract：:In this study we demonstrate the involvement of ras oncogenes in bladder cancer at the level of RNA overexpression. We examined 26 bladder specimens, consisting of paired tumor and adjacent normal tissue and found that H-ras transcripts were overexpressed in 39% of the specimens while K-ras and N-ras in 58% of total s...

journal_title：Cancer letters

authors： Vageli D,Kiaris H,Delakas D,Anezinis P,Cranidis A,Spandidos DA

更新日期：1996-10-22 00:00:00

abstract：:Apoptosis is a gene-directed program that is engaged to efficiently eliminate dysfunctional cells. Evasion of apoptosis may be an important gate to tumor initiation and therapy resistance. Like any other developmental program, apoptosis can be disrupted by several genetic aberrations driving malignant cells into an un...

journal_title：Cancer letters

authors： Yaacoub K,Pedeux R,Tarte K,Guillaudeux T

更新日期：2016-08-10 00:00:00

abstract：:Hamster liver S9 prepared from control animals and animals given 30% glucose in drinking water 48 h before killing was used in studies of benzo[a]pyrene (BaP) and aflatoxin (AFB1)-induced mutagenesis, metabolism of BaP and AFB1, and metabolite binding to calf thymus DNA. BAP-induced mutagenesis in Salmonella typhimuri...

journal_title：Cancer letters

authors： Rubano DC,Teel RW,Strother A

更新日期：1990-07-16 00:00:00