Failure of immunogenic tumors to elicit cytolytic T cells in syngeneic hosts.

abstract：:We carried out a mutational analysis of BRCA1 and BRCA2 genes in 103 individuals from a population in Western Central Spain and we identified nine new variants: two truncating mutations in BRCA2 [2604C>A (Y792X), 8873del4], three missense mutations in BRCA2 [677A>G (H150R), 958G>A (D224N) and 3398A>G (K1057R], and fou...

journal_title：Cancer letters

authors： Salazar R,Cruz-Hernandez JJ,Sanchez-Valdivieso E,Rodriguez CA,Gomez-Bernal A,Barco E,Fonseca E,Portugal T,Gonzalez-Sarmiento R

更新日期：2006-02-20 00:00:00

abstract：:D-501036 is a promising anti-cancer compound that exhibits potent anti-proliferative activity against various types of human cancers through the induction of double strand DNA breaks. To determine drug resistance mechanism related to this class of DNA-damaging agents, a KB-derived D-501036-resistant cell line (S4) was...

journal_title：Cancer letters

authors： Yang YN,Chou KM,Pan WY,Chen YW,Tsou TC,Yeh SC,Cheung CH,Chen LT,Chang JY

更新日期：2011-10-01 00:00:00

abstract：:Vitamin C has been suggested and disputed as an anti-cancer agent. Previous in vitro studies using either primary cell cultures from cancer patients or tumor cell lines have suggested that tumor cells with different lineages may have different sensitivities to ascorbic acid. In this study we report characterization of...

journal_title：Cancer letters

authors： Kao TL,Meyer WJ 3rd,Post JF

更新日期：1993-06-15 00:00:00

abstract：:The human multidrug resistance ABC transporters provide a protective function in our body against a large number of toxic compounds. These proteins, residing in the plasma membrane, perform an active, ATP-dependent extrusion of such xenobiotics. However, the same proteins are also used by the tumor cells to fight vari...

journal_title：Cancer letters

authors： Cervenak J,Andrikovics H,Ozvegy-Laczka C,Tordai A,Német K,Váradi A,Sarkadi B

更新日期：2006-03-08 00:00:00

abstract：:We have used human procathepsin D isolated from supernatant of human breast cancer cell line ZR-75-1 to test its mitogenic activity for a broad spectrum of human-derived cell lines. These cell lines included: breast cancer cell lines ZR-75-1, MDA-MB-436, MBA-MD-483 and MDA-MB-231, B lymphoblastoid cell line Raji, the ...

journal_title：Cancer letters

authors： Vĕtvicka V,Vĕktvicková J,Fusek M

更新日期：1994-05-16 00:00:00

abstract：:A hallmark of most cancer cells is an altered metabolism involving a shift to aerobic glycolysis with lactate production coupled with a higher uptake of glucose as the main source of energy. Lactate dehydrogenase 5 (LDH-5) catalyzes the reduction of pyruvate by NADH to form lactate, thus determining the availability o...

journal_title：Cancer letters

authors： Augoff K,Hryniewicz-Jankowska A,Tabola R

更新日期：2015-03-01 00:00:00

abstract：:The purpose of this study was to investigate the possible role of PI-3K/Akt2 pathway in docetaxel-induced apoptosis. Here we showed that transfection of full-length Akt2 into breast and ovarian cancer cells could provoke Akt phosphorylation and induce an enhanced resistance to docetaxel. FN adhesion promoted Akt phosp...

journal_title：Cancer letters

authors： Xing H,Weng D,Chen G,Tao W,Zhu T,Yang X,Meng L,Wang S,Lu Y,Ma D

更新日期：2008-03-08 00:00:00

abstract：:Potential interaction of Aurora-A amplification and BRCA2 mutation was examined in breast tumours from BRCA2 999del5 mutation carriers (n=20) and non-carriers (n=41). Aurora-A amplification studied by FISH was significantly more common in breast tumours from BRCA2 mutation carriers (p=0.0005). Extensive Aurora-A ampli...

journal_title：Cancer letters

authors： Bodvarsdottir SK,Hilmarsdottir H,Birgisdottir V,Steinarsdottir M,Jonasson JG,Eyfjord JE

更新日期：2007-04-08 00:00:00

abstract：:The quality and frequency of mutations in PTEN gene were assessed in 59 carcinomas and 6 hyperplasias of the endometrium in women. Screening for mutations was done in all exons of PTEN gene by the PCR-SSCP analysis and DNA sequencing. Results were correlated with histological status and clinical features of endometria...

journal_title：Cancer letters

authors： Konopka B,Paszko Z,Janiec-Jankowska A,Goluda M

更新日期：2002-04-08 00:00:00

abstract：:The Wnt signaling pathway has long been known to direct growth and patterning during embryonic development. Recent evidence also implicates this pathway in the development of childhood tumors of the liver, the kidney, the brain, and the pancreas. Here, we review the current evidence on how constitutive activation of t...

journal_title：Cancer letters

authors： Koesters R,von Knebel Doeberitz M

更新日期：2003-08-20 00:00:00

abstract：:We have investigated the effects of hyperthermia on the apoptosis induced by tumor necrosis factor alpha (TNF-alpha). Confluent monolayers of human gastric cancer cell line MKN45 were either treated or untreated with hyperthermia for 1 h. The cells were subsequently stimulated with TNF-alpha. A 24-h incubation with TN...

journal_title：Cancer letters

authors： Kokura S,Yoshida N,Ueda M,Imamoto E,Ishikawa T,Takagi T,Naito Y,Okanoue T,Yoshikawa T

更新日期：2003-11-10 00:00:00

abstract：:This study investigated the role of miR-206 in estrogen receptor-α (ERα)-positive endometrial endometrioid adenocarcinoma (EEC). We profiled miR-206 expression in 30 EEC clinical samples using qRT-PCR, and explored its relationship with ERα and clinical parameters. A luciferase reporter assay assessed the ERα targetin...

journal_title：Cancer letters

authors： Chen X,Yan Q,Li S,Zhou L,Yang H,Yang Y,Liu X,Wan X

更新日期：2012-01-01 00:00:00

abstract：:Pancreatic expression of the p53 tumor suppressor gene was studied in pancreatic adenocarcinomas and chronic pancreatitis. By immunohistochemistry, 16 of 34 (47%) cancers and none of the 24 chronic pancreatitis samples revealed nuclear staining. Sequence analysis indicated that 8 of 24 (33%) cancers were mutated for t...

journal_title：Cancer letters

authors： Casey G,Yamanaka Y,Friess H,Kobrin MS,Lopez ME,Buchler M,Beger HG,Korc M

更新日期：1993-05-14 00:00:00

abstract：:Human PRL-1, PRL-2, and PRL-3 tyrosine phosphatases induce the malignant transformation of epithelial cells. We tested the hypothesis that the oncogenic effects of PRL occur by increasing cellular proliferation. Cells stably transfected with PRL-1 or PRL-2 exhibited 2.7-3.3-fold increases over control cells in the rat...

journal_title：Cancer letters

authors： Werner SR,Lee PA,DeCamp MW,Crowell DN,Randall SK,Crowell PL

更新日期：2003-12-30 00:00:00

abstract：:DDX1, a gene mapping to the 2p24 region, has been observed to be co-amplified with MYCN in neuroblastoma. Co-amplification of the DDX1 gene is a consequence of the short physical distance between the two genes. Recently, it has been found that neuroblastoma cells can show a low increase in MYCN gene copy number, defin...

journal_title：Cancer letters

authors： Defferrari R,Tonini GP,Conte M,Papio F,Sementa AR,Valent A,Schena F,Perri P,Mazzocco K

更新日期：2007-10-18 00:00:00

abstract：:The exact role of mast cells in tumor growth is not clear and multifaceted. In some cases, mast cells stimulate while in others inhibit this process. This dual role may be explained to some extent by the huge number of bioactive molecules stored in mast cell granules, as well as differences between tumor microenvironm...

journal_title：Cancer letters

authors： Ribatti D,Tamma R,Crivellato E

更新日期：2018-10-01 00:00:00

abstract：:Expression of the cytoplasmic soluble form of p53 protein in the different rat colon cancer cell lines transfected and non-transfected with Rous sarcoma virus-33 was studied. Concentrations of the p53 protein were detected by commonly used immunochemical methods after its isolation by affinity chromatography columns w...

journal_title：Cancer letters

authors： Sandler B,Grofova M,Smirnoff P,Zusman R,Zusman I

更新日期：1997-12-23 00:00:00

abstract：:Osteosarcoma is the most common osteogenic malignant tumor characterized by a high level of malignancy, relapse, metastasis and poor prognosis. S100A4 has been implicated in the proliferation, cell cycle progression, and metastasis of many malignant tumors, although the roles of S100A4 in osteosarcoma have not been do...

journal_title：Cancer letters

authors： Ma X,Yang Y,Wang Y,An G,Lv G

更新日期：2010-12-28 00:00:00

abstract：:Tissue samples from germ-free and conventional rats fed pectins with different degrees of esterification (DE) were tested for containing indigenous DNA adducts (I-compounds). For 21 days groups of six germ-free and 10 conventional rats each were fed either pectin-free or with diets containing 7.5% of three differently...

journal_title：Cancer letters

authors： Zunft HJ,Goldin-Lang P,Dongowski G

更新日期：1997-03-19 00:00:00

abstract：:Caveolin-1 has been implicated in cellular transformation and tumorigenesis. We assessed lung cancer specimens for caveolin-1 expression immunohistochemistry. A majority of the cell types in the lung and the bronchial epithelium normally exhibited positive staining for caveolin-1. In adenocarcinomas (ADs) of positive ...

journal_title：Cancer letters

authors： Kato T,Miyamoto M,Kato K,Cho Y,Itoh T,Morikawa T,Okushiba S,Kondo S,Ohbuchi T,Katoh H

更新日期：2004-10-08 00:00:00

abstract：:Tumors are known to cause profound changes in host biology, but the mechanisms responsible for these changes remain unclear. Ornithine decarboxylase (ODC) is a rate-limiting enzyme that catalyzes the biosynthesis of polyamines. The purpose of this study was to examine the effects of MC-26 tumor burden on ODC activity ...

journal_title：Cancer letters

authors： Saydjari R,Beauchamp RD,Townsend CM Jr,Thompson JC

更新日期：1991-06-14 00:00:00

abstract：:To investigate if genomic instability exists in tumors with cytogenetically normal karyotypes, we analyzed four diploid cancer cell lines A204, CAL51, CH1 and SK-UT-1B. We detected subtle genomic changes in all four cell lines. More of these alterations were found in A204 and CH1 than in the microsatellite unstable li...

journal_title：Cancer letters

authors： Mao X,Young BD,Chaplin T,Shipley J,Lu YJ

更新日期：2008-08-18 00:00:00

abstract：:In order to examine the in vivo genotoxic activity of dichlorvos, lambdalacZ transgenic mice (Muta Mouse) were treated i.p. with single (4.4 or 11 mg/kg) or multiple (5 x 11 mg/kg) doses of this agent and sacrificed 4 h or 14 days post-treatment for DNA adduct measurement or mutant frequency analysis, respectively. Ne...

journal_title：Cancer letters

authors： Pletsa V,Steenwinkel MJ,van Delft JH,Baan RA,Kyrtopoulos SA

更新日期：1999-11-15 00:00:00

abstract：:Although overall mortality rate of prostate cancer (PCa) declines in recent years, castration-resistant prostate cancer (CRPC) remains incurable. Clinical evidence indicates that CRPC recurred from hormonal therapy exhibits neuroendocrine differentiated (NED) phenotypes, which could contribute to therapeutic resistanc...

journal_title：Cancer letters

authors： Lin LC,Gao AC,Lai CH,Hsieh JT,Lin H

更新日期：2017-04-10 00:00:00

abstract：:Caveolins, essential scaffold proteins of caveolae, have emerged as versatile molecules that can influence numerous signaling pathways and disease processes. This brief review is focused on the role of caveolins in the physiology and pathology of musculoskeletal system and will discuss the key features of caveolins as...

journal_title：Cancer letters

authors： Serra M,Scotlandi K

更新日期：2009-11-01 00:00:00

abstract：:A hitherto unreported lactate dehydrogenase (LD) isoenzyme, which migrates electrophoretically to the relative position between LD2 and LD3 has been identified in the electropheratogram in 7 of 7 (100%) cultured hepatoma cell lines with various degrees of differentiation and is thus given the name LD2-3. LD2-3 seems t...

journal_title：Cancer letters

authors： Liu TZ,Chen PY,Chiu DT,Wei JS,Chang KS,Lin KH

更新日期：1994-12-09 00:00:00

abstract：:Hypoxia-inducible factor 1 alpha (HIF-1 alpha) that regulates genes involved in response to hypoxia and promotes neo-angiogenesis, is a transcriptional factor for vascular endothelial cell growth factor (VEGF). The aim of this study was to examine the expression of HIF-1 alpha and VEGF gene expressions and their relat...

journal_title：Cancer letters

authors： Nakayama K,Kanzaki A,Hata K,Katabuchi H,Okamura H,Miyazaki K,Fukumoto M,Takebayashi Y

更新日期：2002-02-25 00:00:00

abstract：:Prostate cancer is a major health concern and is treated based on its hormone dependence. Agents that alter hormone action can have substantial biological effects on prostate cancer development and progression. As such, there is significant interest in uncovering the potential effects of endocrine disrupting compound ...

journal_title：Cancer letters

authors： Hess-Wilson JK,Knudsen KE

更新日期：2006-09-08 00:00:00

abstract：:The capacity of the human adrenal gland to metabolize various xenobiotics was investigated. Adrenal microsomal and mitochondrial preparations showed a maximal absorption at 450 nm for dithionite-reduced cytochromes in the presence of carbon monoxide. Occasionally, absorption maxima at 448 nm were observed with both mi...

journal_title：Cancer letters

authors： Papadopoulos D,Seidegard J,Rydström J

更新日期：1984-02-01 00:00:00

abstract：:Most brain tumors are highly resistant to chemotherapy because many chemotherapeutic drugs poorly cross the blood-brain barrier, the blood-cerebrospinal-fluid barrier, and the plasma membrane of the tumor cells. This restricted drug delivery is largely due to the presence of integral plasma membrane proteins belonging...

journal_title：Cancer letters

authors： Nies AT

更新日期：2007-08-28 00:00:00