Enhanced cell cycle progression and down regulation of p21(Cip1/Waf1) by PRL tyrosine phosphatases.

abstract：:A newly found human retrovirus, adult T-cell leukemia virus (ATLV) was shown by means of membrane immunofluorescence to bind to various hematopoietic cells including T-, B- and non-T, non-B-cell lines. Partially purified viral gp46 from culture fluids of ATL virus producer lines also bound efficiently to an ATLV-negat...

journal_title：Cancer letters

authors： Yamamoto N,Chosa T,Koyanagi Y,Tochikura T,Schneider J,Hinuma Y

更新日期：1984-01-01 00:00:00

abstract：:To determine the genotoxic risk associated with therapeutic exposure to 131I, we studied the presence of micronuclei (MN) in binucleated peripheral blood lymphocytes of a group of 22 women, patients of thyroid cancer, who received 131I sodium iodide orally as an adjuvant after total thyroidectomy. The cytogenetic stud...

journal_title：Cancer letters

authors： Gutiérrez S,Carbonell E,Galofréa P,Xamena N,Creus A,Marcos R

更新日期：1995-05-08 00:00:00

abstract：:Vascular recovery or re-angiogenesis after radiotherapy plays a significant role in tumor recurrence, whereas molecular mechanisms of this process remain elusive. In this work, we found that dying glioma cells promoted post-irradiation angiogenesis through a caspase 3 dependent mechanism. Evidence in vitro and in vivo...

journal_title：Cancer letters

authors： Feng X,Yu Y,He S,Cheng J,Gong Y,Zhang Z,Yang X,Xu B,Liu X,Li CY,Tian L,Huang Q

更新日期：2017-01-28 00:00:00

abstract：:Enhanced expression of the nucleotide excision repair gene XPA is associated with resistance to cisplatin treatment in human ovarian cancer. Understanding the cause of enhanced XPA expression will provide new molecular targets for therapy directed at overcoming chemoresistance. Enhanced gene expression in cancer cells...

journal_title：Cancer letters

authors： States JC,Reed E

更新日期：1996-11-29 00:00:00

abstract：:In Mongolian gerbils, the gastric mucosa shows dramatic changes after Helicobacter pylori inoculation. The influence of the timing of N-methyl-N-nitrosourea (MNU) administration after H. pylori inoculation on gastric carcinogenesis was investigated. Ninety-two gerbils were divided into four groups. One group was given...

journal_title：Cancer letters

authors： Maruta F,Sugiyama A,Ishida K,Ikeno T,Murakami M,Kawasaki S,Ota H,Tatematsu M,Katsuyama T

更新日期：2000-11-10 00:00:00

abstract：:Monitoring angiogenesis is potentially an effective strategy for the early detection of cancer. In this study, early detection was achieved by evaluating blood vessel density in the liver using a three-dimensional contrast-enhanced high-frequency ultrasound (CE-HFUS) system and Sonazoid microbubbles. Three-dimensional...

journal_title：Cancer letters

authors： Horie S,Chen R,Li L,Mori S,Kodama T

更新日期：2013-10-10 00:00:00

abstract：:Chronic myeloproliferative disorders (CMPD) are clonal disorders of the hematopoietic stem cell. The myeloid lineage shows increased proliferation with effective maturation, while peripheral leukocytosis, thrombocytosis or elevated red blood cell mass are found. In Philadelphia negative CMPD recurrent cytogenetic abno...

journal_title：Cancer letters

authors： Panani AD

更新日期：2007-09-18 00:00:00

abstract：:By comparing protein profiles of nasopharyngeal carcinoma HONE1 cells to transformed nasopharyngeal epithelial NP 69 cells, several clusters of differentially expressed proteins were identified. The increased expression of cytokeratin 8 (CK8) and pyruvate kinase M2 was a common feature in four NPC cell lines compared ...

journal_title：Cancer letters

authors： Wang Y,He QY,Tsao SW,Cheung YH,Wong A,Chiu JF

更新日期：2008-07-08 00:00:00

abstract：:Id1 promotes carcinogenesis and metastasis, and predicts prognosis of non-small cell lung cancer (NSCLC)-adenocarcionoma patients. We hypothesized that Id1 may play a critical role in lung cancer colonization of the liver by affecting both tumor cells and the microenvironment. Depleted levels of Id1 in LLC (Lewis lung...

journal_title：Cancer letters

authors： Castañón E,Soltermann A,López I,Román M,Ecay M,Collantes M,Redrado M,Baraibar I,López-Picazo JM,Rolfo C,Vidal-Vanaclocha F,Raez L,Weder W,Calvo A,Gil-Bazo I

更新日期：2017-08-28 00:00:00

abstract：:We examined the responsiveness of normal and neoplastic lung cells to agents which stimulate cAMP production. While their basal cAMP levels were similar, spontaneous in vitro transformant E9 cells and tumor-derived PCC4 cells produced much less cAMP in response to 1 microM isoproterenol compared to non-tumorigenic C10...

journal_title：Cancer letters

authors： Lange-Carter CA,Droms KA,Vuillequez JJ,Malkinson AM

更新日期：1992-12-24 00:00:00

abstract：:As a newly discovered deubiquitinating enzyme, ubiquitin-specific protease 22 (USP22) is predictive of therapeutic outcomes in individual cancer patients. However, its clinical effects on malignancy and its roles in conferring resistance to EGFR-TKIs (epidermal growth factor receptor-tyrosine kinase inhibitors) in lun...

journal_title：Cancer letters

authors： Zhang H,Han B,Lu H,Zhao Y,Chen X,Meng Q,Cao M,Cai L,Hu J

更新日期：2018-10-01 00:00:00

abstract：:The effect of vitamin A (retinyl acetate) on lung tumor development in strain A mice exposed to radiation was assessed. Four groups of 75 mice were utilized. Two groups were fed a low vitamin A diet (less than 100 IU/100 g diet) and the other 2 were fed a high vitamin A diet (800 IU/100 g diet). After 2 weeks one grou...

journal_title：Cancer letters

authors： Mian TA,Theiss JC,Gesell TF

更新日期：1984-02-01 00:00:00

abstract：:The widespread consumption of tea as beverage throughout the world has stimulated interest in the possibility of its use in chemoprevention of cancer. The present set of investigation was carried out to evaluate the anticarcinogenic activity of black tea using lung tumorigenesis model in Swiss albino mice. Diethylnitr...

journal_title：Cancer letters

authors： Shukla Y,Taneja P

更新日期：2002-02-25 00:00:00

abstract：:A hallmark of most cancer cells is an altered metabolism involving a shift to aerobic glycolysis with lactate production coupled with a higher uptake of glucose as the main source of energy. Lactate dehydrogenase 5 (LDH-5) catalyzes the reduction of pyruvate by NADH to form lactate, thus determining the availability o...

journal_title：Cancer letters

authors： Augoff K,Hryniewicz-Jankowska A,Tabola R

更新日期：2015-03-01 00:00:00

abstract：:Fluorescence-activated cell sorting (FACS) based on the surface marker CD133 is the most common method for isolating glioma stem cells (GSCs) from heterogeneous glioma cell populations. Optimization of this method will have profound implications for the future of GSC research. Five commonly used digestion reagents, Li...

journal_title：Cancer letters

authors： Lv D,Ma QH,Duan JJ,Wu HB,Zhao XL,Yu SC,Bian XW

更新日期：2016-07-10 00:00:00

abstract：:Peroxiredoxin I (Prx I) is newly discovered oxidative stress inducible protein, having a thioredoxin peroxidase activity. The Prx I expression level in 107 samples out of 60 thyroid lesions, including normal thyroid, tumors and thyroiditis including Graves' disease were examined using immunoblotting. Prx I expression ...

journal_title：Cancer letters

authors： Yanagawa T,Ishikawa T,Ishii T,Tabuchi K,Iwasa S,Bannai S,Omura K,Suzuki H,Yoshida H

更新日期：1999-10-18 00:00:00

abstract：:Human cancer cells in vitro (NHIK 3025), derived from a carcinoma in situ are inactivated when exposed to visible light in the presence of hematoporphyrin. Irradiation at 4 degrees C results in much more efficient inactivation than irradiation at 37 degrees C. Furthermore, a given total light dose is more efficient wh...

journal_title：Cancer letters

authors： Moan J,Christensen T

更新日期：1979-05-01 00:00:00

abstract：:In the present study, we show that concomitant inhibition of Hedgehog (HH) signaling by the glioma-associated oncogene homolog1 (GLI1)-targeting agent GANT61 and the antiapoptotic BCL-2 protein family member MCL-1 by A-1210477 synergistically induces cell death in HH-driven cancers, i.e. rhabdomyosarcoma (RMS) and med...

journal_title：Cancer letters

authors： Meister MT,Boedicker C,Linder B,Kögel D,Klingebiel T,Fulda S

更新日期：2019-11-28 00:00:00

abstract：:In our joint project in the search for anti-tumor promoters from natural plant sources, we carried out a primary screening of 12 phenylpropanoids isolated from Boronia pinnata Sm. (Rutaceae) by examining their possible inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradeca...

journal_title：Cancer letters

authors： Ito C,Itoigawa M,Furukawa H,Ichiishi E,Mukainaka T,Okuda M,Ogata M,Tokuda H,Nishino H

更新日期：1999-07-19 00:00:00

abstract：:In this study we demonstrate the involvement of ras oncogenes in bladder cancer at the level of RNA overexpression. We examined 26 bladder specimens, consisting of paired tumor and adjacent normal tissue and found that H-ras transcripts were overexpressed in 39% of the specimens while K-ras and N-ras in 58% of total s...

journal_title：Cancer letters

authors： Vageli D,Kiaris H,Delakas D,Anezinis P,Cranidis A,Spandidos DA

更新日期：1996-10-22 00:00:00

abstract：:It is known that the ingestion of cooked meat which contains carcinogenic heterocyclic amines causes increase in urinary mutagenicity in humans. Using 6 healthy non-smokers, we examined the effect of 3-week oral administration of Lactobacillus casei (bacilli commonly present in yoghurt), on the urinary mutagenicity de...

journal_title：Cancer letters

authors： Hayatsu H,Hayatsu T

更新日期：1993-09-30 00:00:00

abstract：:Present studies show the in vitro addition of glutathione (GSH) can significantly alter selenite induced growth inhibition of mammary tumor cell line 13 (CMT-13). Preincubation with 100 microM GSH for 24 h partially prevented the growth inhibition caused by 12.6 microM selenite. Pre-incubation with 100 microM GSH for ...

journal_title：Cancer letters

authors： Kuchan MJ,Milner JA

更新日期：1991-05-01 00:00:00

abstract：:N-[2-(p-bromocinnamylmethylamino) ethyl]-5-isoquinolinesulfonamide (H-87), a newly synthesized inhibitor of protein kinase A, significantly decreased the drug resistance of multidrug resistant human U937/M cells, mouse FM3A/M and P388/M cells. Northern blot analysis showed MDR1 gene expression was decreased in H-87-tr...

journal_title：Cancer letters

authors： Kim SH,Park JI,Chung BS,Kang CD,Hidaka H

更新日期：1993-10-15 00:00:00

abstract：PURPOSE:The purpose of this study is to examine the changes in the number of HSF1 granules in the nucleus caused by different degree of heat stress. MATERIALS AND METHODS:A human esophageal cancer cell line, TE-2, was used. HSF1 granules were examined in an immunofluorescence study, and the changes in the average numb...

journal_title：Cancer letters

authors： Nonaka T,Akimoto T,Mitsuhashi N,Tamaki Y,Nakano T

更新日期：2003-12-08 00:00:00

abstract：:Mining and mineral processing are important industries in the United States. A large number of workers are potentially exposed to silica during mining and to glass fibers during manufacturing. There is a concern regarding lung cancer risk among workers exposed to silica and glass fibers. Our previous studies showed th...

journal_title：Cancer letters

authors： Gao H,Brick J,Ong S,Miller M,Whong WZ,Ong T

更新日期：1997-01-15 00:00:00

abstract：:Improvements in technologies to yield purer circulating tumor cells (CTCs) will enable a broader range of clinical applications. We have previously demonstrated the use of a commercially available cell-adhesion matrix (CAM) assay to capture invasive CTCs (iCTCs). To improve the purity of the isolated iCTCs, here we us...

journal_title：Cancer letters

authors： Premasekharan G,Gilbert E,Okimoto RA,Hamirani A,Lindquist KJ,Ngo VT,Roy R,Hough J,Edwards M,Paz R,Foye A,Sood R,Copren KA,Gubens M,Small EJ,Bivona TG,Collisson EA,Friedlander TW,Paris PL

更新日期：2016-09-28 00:00:00

abstract：:Liver microsomes from control and treated rats (P4501A, 2B, 2E1-induced) metabolize at variable metabolic rates eight N-nitroso-di-n-alkylamines, including five symmetrical (N-nitroso-dimethyl, -diethyl, -dipropyl, -dibutyl and -diamyl-amines) and four asymmetrical (N-nitrosomethylethyl, methylpropyl, methylbutyl, and...

journal_title：Cancer letters

authors： Bellec G,Goasduff T,Dreano Y,Menez JF,Berthou F

更新日期：1996-02-27 00:00:00

abstract：:Heat shock protein 90 (HSP90) is a highly conserved molecular chaperone that facilitates the maturation of a wide range of proteins, and it has been recognized as a crucial facilitator of oncogene addiction and cancer cell survival. Although HSP90 function is regulated by a variety of post-translational modifications,...

journal_title：Cancer letters

authors： Hamamoto R,Toyokawa G,Nakakido M,Ueda K,Nakamura Y

更新日期：2014-08-28 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a highly lethal malignancy mostly because of de novo and acquired resistance to conventional chemotherapy. Constitutive activation of Akt and nuclear factor-κB (NF-κB) represent major cellular abnormalities associated with both the pathogenesis and therapeutic resistance of HCC. The a...

journal_title：Cancer letters

authors： Ma Y,Wang J,Liu L,Zhu H,Chen X,Pan S,Sun X,Jiang H

更新日期：2011-02-01 00:00:00

abstract：:Populations consuming soybeans have reduced rates of breast, colon and prostate cancer possibly due, in part, to the presence in soybeans of two estrogenic isoflavones, genistein and daidzein. This study investigated the genotoxicity of these soya isoflavones and their interactions with 7,12-dimethylbenz[a]anthracene ...

journal_title：Cancer letters

authors： Giri AK,Lu LJ

更新日期：1995-08-16 00:00:00