Anti-tumor-promoting effects of phenylpropanoids on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis.

abstract：:In this study, we investigated the role of Ca(2+) in curcumin-induced paraptosis, a cell death mode that is accompanied by dilation of mitochondria and the endoplasmic reticulum (ER). Curcumin induced mitochondrial Ca(2+) overload selectively in the malignant breast cancer cells, but not in the normal breast cell, con...

journal_title：Cancer letters

authors： Yoon MJ,Kim EH,Kwon TK,Park SA,Choi KS

更新日期：2012-11-28 00:00:00

abstract：:The involvement of beta-catenin gene alterations in pancreatic duct carcinogenesis induced by N-nitrosobis(2-oxopropyl)amine (BOP) in hamsters was examined by polymerase chain reaction-single strand conformation polymorphism analysis and the expression of beta-catenin protein was examined by immunohistochemistry. No m...

journal_title：Cancer letters

authors： Kubozoe T,Tsujiuchi T,Murata N,Sasaki Y,Tsunoda T,Konishi Y,Tsutsumi M

更新日期：2001-07-10 00:00:00

abstract：:Cyclin A is an S and G2/M phase regulatory protein and associates with Skp 2 in many transformed cells. Our previous results showed that 12 (39%) and 17 (55%) out of 31 hepatocellular carcinoma (HCC) patients exhibited higher protein expression levels of cyclin A and Skp 2, respectively, in their tumorous compared to ...

journal_title：Cancer letters

authors： Chao Y,Shih YL,Chen HJ,Lee SD,Huang TS

更新日期：1999-05-03 00:00:00

abstract：:This aim of this study was to measure the typical free radical-induced products of DNA bases in cellular DNA of cervical cancer tissues directly irradiated by applying brachytherapy to the patients. Significant increases in the amounts of modified bases over the control level were observed in the samples isolated afte...

journal_title：Cancer letters

authors： Foksinski M,Jaruga P,Makarewicz R,Olinski R

更新日期：1998-10-23 00:00:00

abstract：:Cap-mediated translation is the default mechanism for the synthesis of proteins in eukaryotic cells. Increasingly, malignant cells have been found to have deregulation of this process. Return of normal translational control is associated with loss of tumorigenic potential in pre-clinical models. Currently, a variety o...

journal_title：Cancer letters

authors： Thumma SC,Kratzke RA

更新日期：2007-12-08 00:00:00

abstract：:Osteosarcoma (OS) is the most frequent paediatric bone cancer, responsible for 9% of all cancer-related deaths in children. In this paper, a new strategy based on delivering edelfosine (ET) in lipid nanoparticles (LN) was explored in order to target the primary tumour and eliminate metastases. The in vitro and in vivo...

journal_title：Cancer letters

authors： González-Fernández Y,Brown HK,Patiño-García A,Heymann D,Blanco-Prieto MJ

更新日期：2018-08-28 00:00:00

abstract：:Transendothelial migration (TEM) of tumor cells is a crucial step in metastasis formation. The prevailing paradigm is that the mechanism underlying TEM of tumor cells is similar to that of leukocytes involving adhesion molecules and chemokines. Fractalkine (CX3CL1) is a unique membrane-bound chemokine that functions a...

journal_title：Cancer letters

authors： Nevo I,Sagi-Assif O,Meshel T,Ben-Baruch A,Jöhrer K,Greil R,Trejo LE,Kharenko O,Feinmesser M,Yron I,Witz IP

更新日期：2009-01-08 00:00:00

abstract：:MUTYH-associated polyposis (MAP) is an autosomal recessive condition predisposing to colorectal cancer, caused by constitutional biallelic mutations in the base excision repair (BER) gene MUTYH. Colorectal tumours from MAP patients display an excess of somatic G>T mutations in the APC and KRAS genes due to defective B...

journal_title：Cancer letters

authors： Tricarico R,Bet P,Ciambotti B,Di Gregorio C,Gatteschi B,Gismondi V,Toschi B,Tonelli F,Varesco L,Genuardi M

更新日期：2009-02-18 00:00:00

abstract：:To determine the genotoxic risk associated with therapeutic exposure to 131I, we studied the presence of micronuclei (MN) in binucleated peripheral blood lymphocytes of a group of 22 women, patients of thyroid cancer, who received 131I sodium iodide orally as an adjuvant after total thyroidectomy. The cytogenetic stud...

journal_title：Cancer letters

authors： Gutiérrez S,Carbonell E,Galofréa P,Xamena N,Creus A,Marcos R

更新日期：1995-05-08 00:00:00

abstract：:Glioblastoma multiforme (GBM) is a brain tumor with a high mortality rate. Surgical resection combined with radiotherapy and chemotherapy is the standard treatment for GBM patients, but the 5-year survival rate of patients despite this treatment is low. Immunotherapy has attracted increasing attention in recent years....

journal_title：Cancer letters

authors： Wang H,Zhou H,Xu J,Lu Y,Ji X,Yao Y,Chao H,Zhang J,Zhang X,Yao S,Wu Y,Wan J

更新日期：2021-01-01 00:00:00

abstract：:The effect of consumption of Brussels sprouts on the excretion of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) into human urine was investigated. Ten non-smoking volunteers (five males and five females) were randomly assigned to two groups. Five volunteers started on a diet of 300 g of glucosinolate-free vegetables w...

journal_title：Cancer letters

authors： Verhagen H,de Vries A,Nijhoff WA,Schouten A,van Poppel G,Peters WH,van den Berg H

更新日期：1997-03-19 00:00:00

abstract：:The intracellular concentrations of adenosine 3',5'-cyclic monophosphate (cAMP) in colonic tumors induced in adult male Holtzman rats by 1,2-dimethylhydrazine (DMH) were found to be 1/2 the concentration found in normal large bowel tissue. Intracellular concentrations of guanosine 3'-5'-cyclic monophosphate (cGMP) in ...

journal_title：Cancer letters

authors： Stevens RH,Loven DP,Osborne JW,Prall JP,Lawson AJ

更新日期：1978-01-01 00:00:00

abstract：:The incidence of pediatric cancers is rising steadily across the world, along with the challenges in understanding the molecular mechanisms and devising effective therapeutic strategies. Pediatric cancers are presented with diverse molecular characteristics and more distinct subtypes when compared to adult cancers. Re...

journal_title：Cancer letters

authors： Vellichirammal NN,Chaturvedi NK,Joshi SS,Coulter DW,Guda C

更新日期：2021-02-28 00:00:00

abstract：:The fruiting body of Antrodia camphorata is well known in Taiwan as a traditional medicine for treating cancer and inflammation. The purpose of this study was to evaluate the apoptotic effects of ethylacetate extract from A. camphorata (EAC) fruiting bodies in two human liver cancer cell lines, Hep G2 and PLC/PRF/5. T...

journal_title：Cancer letters

authors： Hsu YL,Kuo YC,Kuo PL,Ng LT,Kuo YH,Lin CC

更新日期：2005-04-18 00:00:00

abstract：:Tumor biopsies obtained from 25 Saudi Arab patients with nasopharyngeal carcinoma (NPC) were examined for the presence of Epstein-Barr virus (EBV) DNA detected by the polymerase chain reaction (PCR) and for the incidence of p53 mutations screened by a combination of PCR, single strand conformation polymorphism (SSCP) ...

journal_title：Cancer letters

authors： Nasrin N,Taiba K,Hannan N,Hannan M,al-Sedairy S

更新日期：1994-07-29 00:00:00

abstract：:In esophageal squamous cell carcinoma (SCC), we used immunohistochemical analysis to further elucidate the correlation of p53 protein expression with clinicopathological factors, as well as with risk factors, such as tobacco smoking, alcohol consumption and a family history of cancer, using odds ratios (ORs). The expr...

journal_title：Cancer letters

authors： Kato H,Yoshikawa M,Miyazaki T,Nakajima M,Fukai Y,Tajima K,Masuda N,Tsukada K,Fukuda T,Nakajima T,Kuwano H

更新日期：2001-06-10 00:00:00

abstract：:Incubation of mouse epidermal cells (HEL-37) with phospholipase C (Clostridium perfringens) caused about a 50% decrease in the specific binding of [20-3H]phorbol-12,13-dibutyrate. Phospholipase C caused a decrease in the apparent number of binding sites from 2.86 X 10(5) to 1.21 X 10(5) per cell with little effect on ...

journal_title：Cancer letters

authors： Jones MJ,Murray AW

更新日期：1983-05-01 00:00:00

abstract：:Oleanolic acid (OA, 3β-hydroxyolean-12-en-28-oic acid) is a ubiquitous pentacyclic multifunctional triterpenoid, widely found in several dietary and medicinal plants. Natural and synthetic OA derivatives can modulate multiple signaling pathways including nuclear factor-κB, AKT, signal transducer and activator of trans...

journal_title：Cancer letters

authors： Shanmugam MK,Dai X,Kumar AP,Tan BK,Sethi G,Bishayee A

更新日期：2014-05-01 00:00:00

abstract：:The identification of the breast cancer susceptibility genes BRCA1 and BRCA2 a few years ago has been greeted with great excitement and has raised hopes that they might illuminate the common mechanisms of this disease. Today we have to recognize that these expectations remain unfulfilled. Mutations in BRCA1 and BRCA2 ...

journal_title：Cancer letters

authors： Schwab M,Claas A,Savelyeva L

更新日期：2002-01-10 00:00:00

abstract：:The vast majority of cancer deaths are caused by the formation of metastases rather than the primary tumor itself. Despite this clinical importance, the molecular and cellular events that support the dissemination of cancer cells are not yet fully unraveled. We have previously shown that CDX2, a homeotic transcription...

journal_title：Cancer letters

authors： Platet N,Hinkel I,Richert L,Murdamoothoo D,Moufok-Sadoun A,Vanier M,Lavalle P,Gaiddon C,Vautier D,Freund JN,Gross I

更新日期：2017-02-01 00:00:00

abstract：:Despite its documented role in cell cycle regulation, over-expression of the cyclin-dependent kinase activator CDC25A does not consistently correlate with worse cancer patient outcomes or predict successful clinical response to CDC25A inhibition. The current study was undertaken to investigate CDC25A in skin cancer an...

journal_title：Cancer letters

authors： Al-Matouq J,Holmes T,Hammiller B,Tran N,Holmes M,Freeman SC,Hansen LA

更新日期：2017-12-01 00:00:00

abstract：:Populations consuming soybeans have reduced rates of breast, colon and prostate cancer possibly due, in part, to the presence in soybeans of two estrogenic isoflavones, genistein and daidzein. This study investigated the genotoxicity of these soya isoflavones and their interactions with 7,12-dimethylbenz[a]anthracene ...

journal_title：Cancer letters

authors： Giri AK,Lu LJ

更新日期：1995-08-16 00:00:00

abstract：:Hypusine formation on the eukaryotic initiation factor 5A (eIF-5A) precursor is ubiquitously present in eukaryotic cells and archebacteria. In this reaction, deoxyhypusine synthase catalyzes the conversion of one unique lysine residue on eIF-5A to deoxyhypusine using spermidine as the substrate. Hydroxylation of the d...

journal_title：Cancer letters

authors： Chen ZP,Chen KY

更新日期：1997-05-19 00:00:00

abstract：:MICAL2 is a tumor-promoting factor involved in cell migration, invasion, deformation, and proliferation not yet fully explored in lung adenocarcinoma (LUAD). This study demonstrated that MICAL2 was overexpressed and cytoplasm-enriched in LUAD tissues. Moreover, high cytoplasmic MICAL2 and/or total MICAL2 expression le...

journal_title：Cancer letters

authors： Zhou W,Liu Y,Gao Y,Cheng Y,Chang R,Li X,Zhou Y,Wang S,Liang L,Duan C,Zhang C

更新日期：2020-07-28 00:00:00

abstract：:The present study evaluates the postnatal efficacy of Momordica charantia peel, pulp, seed and whole fruit extract via assessing the modulation in the biotransformation system enzymes of suckling neonates and lactating mice. The peel, seed or whole fruit extract of Momordica (100 microl/animal/day) independently induc...

journal_title：Cancer letters

authors： Singh A,Singh SP,Bamezai R

更新日期：1998-01-09 00:00:00

abstract：:Ellagic acid (EA) is a polyphenol found in several plants and fruits. The objectives of this study were to examine the molecular mechanisms by which EA inhibits pancreatic cancer growth in Balb C nude mice. PANC-1 cells were injected subcutaneously into Balb c nude mice, and tumor-bearing mice were treated with EA. Th...

journal_title：Cancer letters

authors： Zhao M,Tang SN,Marsh JL,Shankar S,Srivastava RK

更新日期：2013-09-01 00:00:00

abstract：:The time-dependent promotion activity of 17beta-estradiol (E2) by initiation with N-ethyl-N-nitrosourea (ENU) on induction of mouse uterine endometrial proliferative lesions was examined. Illumination-induced persistent estrous female CD-1 mice were divided into five groups at 9 weeks of age. At 10 weeks of age, mice ...

journal_title：Cancer letters

authors： Takahashi M,Nishimura S,Miyajima K,Sasahara K,Yoshida M,Ando J,Maekawa A

更新日期：2001-04-26 00:00:00

abstract：:Recently developed quantitative and high-throughput technologies that allow automated and rapid screening of the whole genome, transcriptome and proteome have revolutionized the field of cancer genetics. At the same time, new challenges are met, e.g. the need for improved data analysis and standardization of tumor sam...

journal_title：Cancer letters

authors： De Preter K,Vandesompele J,Heimann P,Kockx MM,Van Gele M,Hoebeeck J,De Smet E,Demarche M,Laureys G,Van Roy N,De Paepe A,Speleman F

更新日期：2003-07-18 00:00:00

abstract：:The aim of this study was to investigate the interaction of tamoxifen (TAM) with the so-called Type II estrogen binding sites (Type II EBS) in both the cytosolic and the nuclear fraction of the ER-negative A 2780 human ovarian cancer cell line and in an ER-negative ovarian cancer tissue. Although cytosolic and nuclear...

journal_title：Cancer letters

authors： Ferrandina G,Ranelletti FO,Scambia G,Benedetti Panici P,D'Agostino G,Piantelli M,Isola G,Mancuso S

更新日期：1995-09-04 00:00:00

abstract：:We previously demonstrated that female Sprague-Dawley rats fed AIN-93G diets containing soy protein isolate (SPI+) had lower DMBA-induced mammary tumor incidence than those fed diets containing casein (CAS), due partly to altered Phase I metabolism with soy. Here, we evaluated the tumor protective effects of these sam...

journal_title：Cancer letters

authors： Simmen RC,Eason RR,Till SR,Chatman L Jr,Velarde MC,Geng Y,Korourian S,Badger TM

更新日期：2005-06-16 00:00:00