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Autophagy regulation as a promising approach for improving cancer immunotherapy.

Abstract：

:Autophagy plays a critical role in intracellular metabolism and maintaining cellular homeostasis. Certain tumor cells present a higher basal autophagy rate and autophagy inhibition can lead to impaired metabolic dysfunction in autophagy-dependent tumor cells. Autophagy status in immune cells dictates their fate and response to antigen; however, autophagy in immune cells may be beneficial or detrimental depending on the developmental stage of the cell and more specifically its degree of differentiation. Autophagy-deficient hosts present variations in many metabolites, proteins and enzymes that may have tumor-promoting or -inhibiting effects. The centrality of autophagy in the metabolism of some cancers and immune cells poses as a critical target whose mechanisms must be further unraveled to optimize patient response and prevent tumor recurrence.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Ishimwe N,Zhang W,Qian J,Zhang Y,Wen L

doi

10.1016/j.canlet.2020.01.034

subject

Has Abstract

pub_date

2020-04-10 00:00:00

pages

34-42

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(20)30048-3

journal_volume

475

pub_type

杂志文章,评审

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