Abstract:
:Vaccines containing synthetic peptides derived from tumor-associated antigens (TAA) can elicit potent cytotoxic T lymphocyte (CTL) response if they are formulated in an optimal vaccine delivery system. The aim of this study was to develop a simple and effective lipid-based vaccine delivery system using P5 HER2/neu-derived peptide conjugated to Maleimide-PEG2000-DSPE. The conjugated lipid was then incorporated into liposomes composed of DMPC:DMPG:Chol:DOPE containing Monophosphoryl lipid A (MPL) (Lip-DOPE-P5-MPL). Different liposome formulations were prepared and characterized for their physicochemical properties. To evaluate anti-tumoral efficacy, BALB/c mice were immunized subcutaneously 3 times in two-week intervals and the generated immune response was studied. The results demonstrated that Lip-DOPE-P5-MPL induced a significantly higher IFN-γ production by CD8+ T cells intracellularly which represents higher CTL response in comparison with other control formulations. CTL response induced by this formulation caused the lowest tumor size and the longest survival time in a mice model of TUBO tumor. The encouraging results achieved by Lip-DOPE-P5-MPL formulation could make it a promising candidate in developing effective vaccines against Her2 positive breast cancers.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Shariat S,Badiee A,Jalali SA,Mansourian M,Yazdani M,Mortazavi SA,Jaafari MRdoi
10.1016/j.canlet.2014.09.016subject
Has Abstractpub_date
2014-12-01 00:00:00pages
54-60issue
1eissn
0304-3835issn
1872-7980pii
S0304-3835(14)00528-Xjournal_volume
355pub_type
杂志文章相关文献
CANCER LETTERS文献大全abstract::Exosomes are 30-100 nm small membrane vesicles of endocytic origin that are secreted by all types of cells, and can also be found in various body fluids. Increasing evidence implicates that exosomes confer stability and can deliver their cargos such as proteins and nucleic acids to specific cell types, which subsequen...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2017.08.003
更新日期:2017-10-28 00:00:00
abstract::Epstein-Barr virus (EBV) has been well documented in the aetiology of nasopharyngeal carcinoma (NPC), although its role as well as the genetic basis in the genesis of NPC have not been elucidated. The p53 gene mutations are infrequently found in NPC, but the expression of p53 protein, as well as bcl-2 oncoprotein, has...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(00)00582-6
更新日期:2000-11-28 00:00:00
abstract::Bcl-2 agonist of cell death (BAD) is a BH3-only member of the Bcl-2 family which possesses important regulatory function in apoptosis. BAD has also been shown to possess many non-apoptotic functions closely linked to cancer including regulation of glycolysis, autophagy, cell cycle progression and immune system develop...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2017.11.017
更新日期:2018-02-28 00:00:00
abstract::Dibenzo[a,e]fluoranthene ( DBF ), a non- alternant carcinogenic polycyclic aromatic hydrocarbon (PAH), binds covalently to DNA. The main adducts were characterized as covalent additions of its bay-region and pseudo-bay-region diol-epoxides. The structure of these 2 adducts was analyzed by mass spectrometry using their...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(84)90165-4
更新日期:1984-04-01 00:00:00
abstract::This study was carried out to evaluate the diagnostic utility of autofluorescence photography for oral mucosal lesions. The materials consisted of 15 chemically-induced lesions containing carcinomas in 15 hamsters, and 32 oral lesions in 30 patients. In the animal models, orange fluorescence was detected in all squamo...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(96)04388-1
更新日期:1996-11-12 00:00:00
abstract::Approximately 25% of stage III colorectal cancer patients do not benefit from standard adjuvant chemotherapies. To identify biomarkers for nonresponders, fresh-frozen tissues of 19 nonresponders and 16 responders were analyzed with gene expression and microRNA arrays. Fifty-nine genes and 17 miRNAs were differentially...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2013.04.017
更新日期:2013-08-09 00:00:00
abstract::Experimental data were provided to demonstrate the inhibitory effects of retinoids (retinal, retinoic acid, retinyl acetate and retinyl palmitate) and carotenoids (beta-carotene, lycopene and crocetin) on the growth and development of the C-6 glioma cells inoculated in rats. In the pretreatment experiments, most of th...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(89)90050-5
更新日期:1989-11-30 00:00:00
abstract::Apoptosis plays a role in the elimination of DNA-damaged cells thus protecting the host from cancer development. Some data indicate that normal variations within the sequence of apoptotic genes may lead to suboptimal apoptotic capacity and therefore increased cancer risk. We tested 19 coding apoptotic gene SNPs in 2-s...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2009.01.012
更新日期:2009-06-18 00:00:00
abstract::In a development trial for an initiation bioassay system, cell proliferation kinetics after partial hepatectomy (PH) or CCl4 administration (1 ml/kg b.w., i.g.) and the effect of administration time after PH or CCl4 treatment on liver cell foci induction by the direct and indirect non-hepatocarcinogens, N-methyl-N'-ni...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(97)00222-x
更新日期:1997-09-16 00:00:00
abstract::(-)-Epigallocatechin-3-gallate (EGCG), a major green tea polyphenol, was tested for in vitro cytotoxicity against human laryngeal epidermoid carcinoma of the larynx Hep2 cells. EGCG-induced apoptotic cell death accompanied by a change in the cell cycle. However, EGCG did not result in caspase activation, nor did a cas...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2009.08.027
更新日期:2010-04-01 00:00:00
abstract::The peptide aptamer DUP-1 targets prostate-specific membrane antigen (PSMA)-negative cells, while the RNA aptamer A10-3.2 targets PSMA-positive prostate cancer cells. Moreover, the tumor-suppressor gene phosphatase and tensin homolog (PTEN) and the chemotherapeutic agent doxorubicin (DOX) effectively inhibit prostate ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.10.003
更新日期:2016-12-28 00:00:00
abstract::Low-frequency electromagnetic fields enhance the induction of mammary gland tumors in rats using nitrosomethyl urea. The incidence of tumors depended on the duration of exposure to static (dc) and variable (ac) magnetic fields. Variable magnetic fields induced mammary gland cancer much more frequently than static ones...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(91)90079-w
更新日期:1991-12-09 00:00:00
abstract::Inheritance of certain polymorphic metabolizing genes is associated with the development of a number of environmental cancers and may also influence the clinicopathological tumor outcome. We have investigated the association between the inheritance of the polymorphic cytochrome P-450 2D6 (CYP2D6) gene and the developm...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(97)00265-6
更新日期:1997-10-28 00:00:00
abstract::Anticancer properties of chemically synthesized compounds have continuously been optimized for better efficacy and selectivity. Derivatives of heterocyclic compounds are well known to have selective antiproliferative effect against many types of cancer. In this study, we investigated the ability of an indigenously syn...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.02.028
更新日期:2016-06-01 00:00:00
abstract::HGT cells are a human gastric cell line derived from a tumour of the stomach. We have investigated the effects of lipoxygenase and cyclooxygenase metabolism inhibitors on HGT cell proliferation, on fatty acid composition of HGT cells and on the incorporation and distribution of arachidonic acid (AA) in HGT lipids. The...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(93)90189-g
更新日期:1993-09-15 00:00:00
abstract::In this study we have compared the anti-proliferative effects of transforming growth factor-beta (TGF-beta), N,N-dimethylformamide (DMF) and retinoic acid (RA) on a moderately-differentiated colon carcinoma cell line (JVC). TGF-beta, DMF and RA inhibited the anchorage-independent growth and induced morphological chang...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(88)90014-6
更新日期:1988-06-15 00:00:00
abstract::The NM23 family proteins are involved in a variety of biological processes including tumor metastasis, development, and differentiation; however, their functions in the regulation of cellular proliferation are poorly understood. We have investigated the role of one NM23 family protein, NM23H2, in the regulation of cel...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2008.10.018
更新日期:2009-03-18 00:00:00
abstract::The T-cell lymphoma cell line YACUT was fused with the Mls-1a antigen-responsive non-tumorigenic T-cell line G4 to construct growth-arrested hybrids which could be induced to proliferate in the presence of Mls-1a antigen. Prolonged growth of the hybrids by repeated antigenic stimulation resulted in the emergence of ce...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(96)04135-3
更新日期:1996-03-29 00:00:00
abstract::Cancerous breast hyperthermia is seemingly associated with non-neurological vasodilation modulated by nitric oxide (NO). NO, associated with enhanced immune response, is produced autocatalytically involving ferritin as the supplier of Fe2+, which catalyses the formation of NO. NO, in turn, releases Fe2+ from ferritin....
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/0304-3835(94)90354-9
更新日期:1994-08-29 00:00:00
abstract::Gene delivery vectors, including adenovirus (Ad) and adeno-associated virus (AAV), are inefficient and non-selective for cancer due to low levels of viral receptors with high levels on other tissues, including liver. We tested Ads and AAVs with the SIGYPLP-targeting peptide inserted into virus capsids for transduction...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2003.07.003
更新日期:2003-11-25 00:00:00
abstract::The notions of inter- and intra-tumour heterogeneity (ITH) have been recognised for many years but recent advances in sequencing technology are allowing the true extent of both forms of heterogeneity to be revealed in detail for the first time. In this review we examine the current evidence for ITH, the possibility of...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2012.10.031
更新日期:2013-11-01 00:00:00
abstract::5-fluorouracil (5-FU) is widely used in chemotherapy for colorectal cancer (CRC), but a high rate of chemoresistance reduces its effectiveness in clinical treatment. We found remarkably decreased expression of forkhead box 3 (FoxO3) protein, a tumor inhibitor, in 5-FU-resistant SW620 and HCT-8 (SW620/5-FU and HCT-8/5-...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2019.11.042
更新日期:2020-02-01 00:00:00
abstract::C57BL/10 mice transgenic for HLA-A2 were immunized with either a full-length DNA-construct of the tumor suppressor p53 or with a minigene encoding the p53-derived immunodominant peptide p53(264)LLGRNSFEV272 (L9V). Vaccination with the full-length p53 construct induced potent cytotoxic activity of splenocytes against L...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(98)00353-x
更新日期:1999-04-01 00:00:00
abstract::The underlying molecular mechanism of lung cancer drug resistance is poorly understood. The mediator of endoplasmic reticulum stress CHOP (DNA damage inducible transcript 3) promotes stress-induced apoptosis and appears to function as a transcription factor in multiple diseases. However, its potential contributions to...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2018.04.028
更新日期:2018-08-01 00:00:00
abstract::Methylation of liver and nasal mucosal DNA at the O6 position of guanine (O6-MeG) was measured in intact and castrated male rats after a dose of N-nitrosobis(2-oxopropyl)amine (BOP) (20 mg/kg; i.p.). There were no differences in O6-MeG persistence in liver DNA from either group. In the nasal mucosa more O6-MeG was det...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(90)90008-l
更新日期:1990-08-01 00:00:00
abstract::RNA interference (RNAi), a natural cellular mechanism for RNA-guided regulation of gene expression could in fact become new therapeutic modality if an appropriate efficient delivery strategy that is also reproducible and safe will be developed. Numerous efforts have been made for the past eight years to address this c...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2012.08.024
更新日期:2013-07-01 00:00:00
abstract::Selenium-dependent (Se-GSH-Px), selenium-independent (non-Se-GSH-Px) glutathione peroxidase and glutathione reductase (GSSG-Rx) activities have been determined in cancerous and non-cancerous human adult kidney. Large inter-individual variation in the activities of all enzymes tested were found in both tumour and non-t...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(95)03710-e
更新日期:1995-05-04 00:00:00
abstract::Chimeric antigen receptor (CAR) T cell therapy is one of the most promising immunotherapies in the past decade. It brings hope for cure to patients with previously refractory hematological malignancies. However, when translating this strategy into non-hematologic malignancies, the antitumor activity from multiple clin...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2021.01.014
更新日期:2021-01-19 00:00:00
abstract::Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver cancer. Appropriate treatment of this aggressive and heterogeneous cancer requires accurate staging and prognostic stratification, as does patient selection for clinical trials. Over the past two decades, several staging systems and prognost...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2019.114426
更新日期:2019-09-28 00:00:00
abstract::Telomerase activity (TA) and telomerase reverse transcriptase (rTERT) were investigated in Sprague-Dawley rats, killed at 6 and 12 h, and 1, 2, 3, 7, and 14 days after 90% pancreatectomy (px), by TRAPeze enzyme-linked immunosorbent assay telomerase detection and reverse transcriptase-polymerase chain reaction. TA incr...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(02)00320-8
更新日期:2002-12-01 00:00:00