Abstract：
:Gene delivery vectors, including adenovirus (Ad) and adeno-associated virus (AAV), are inefficient and non-selective for cancer due to low levels of viral receptors with high levels on other tissues, including liver. We tested Ads and AAVs with the SIGYPLP-targeting peptide inserted into virus capsids for transduction in a panel of cancer cells. Six of twelve lines (C8161, PC-3, G-CCM, MKN-45, LnCAP and A549) were transduced, independently of native viral tropism. Furthermore the candidate cancer gene therapy promoter FLT-1 was active in three of these six cell lines. This offers the potential for dual targeting of selected cancer cells.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Nicklin SA,Dishart KL,Buening H,Reynolds PN,Hallek M,Nemerow GR,Von Seggern DJ,Baker AHdoi
10.1016/j.canlet.2003.07.003keywords:
subject
Has Abstractpub_date
2003-11-25 00:00:00pages
165-73issue
2eissn
0304-3835issn
1872-7980pii
S0304383503005160journal_volume
201pub_type
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