Abstract:
:The pharmacological specificity of adrenergic receptors in the plasma membrane of rat ascites hepatoma AH130 cells was compared with that in normal rat hepatocytes. The number of [125I]iodocyanopindolol-binding sites was much greater in AH130 cells than in the hepatocytes. We characterized the alpha-adrenergic receptor subtypes using the alpha 1-selective ligand [3H]prazosin and the alpha 2-selective ligand [3H]clonidine. AH130 cells had fewer prazosin-binding sites than the hepatocytes and about 8 times as many clonidine-binding sites of high affinity. The results showed that the adrenergic receptors in AH130 cells have pharmacological properties that are very different from those of the receptors in normal rat hepatocytes.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Sanae F,Miyamoto K,Koshiura Rdoi
10.1016/0304-3835(88)90069-9subject
Has Abstractpub_date
1988-04-01 00:00:00pages
267-73issue
3eissn
0304-3835issn
1872-7980pii
0304-3835(88)90069-9journal_volume
39pub_type
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