In vitro anticancer properties and biological evaluation of novel natural alkaloid jerantinine B.


:Natural products play a pivotal role in medicine especially in the cancer arena. Many drugs that are currently used in cancer chemotherapy originated from or were inspired by nature. Jerantinine B (JB) is one of seven novel Aspidosperma indole alkaloids isolated from the leaf extract of Tabernaemontana corymbosa. Preliminary antiproliferative assays revealed that JB and JB acetate significantly inhibited growth and colony formation, accompanied by time- and dose-dependent apoptosis induction in human cancer cell lines. JB significantly arrested cells at the G2/M cell cycle phase, potently inhibiting tubulin polymerisation. Polo-like kinase 1 (PLK1; an early trigger for the G2/M transition) was also dose-dependently inhibited by JB (IC50 1.5 µM). Furthermore, JB provoked significant increases in reactive oxygen species (ROS). Annexin V+ cell populations, dose-dependent accumulation of cleaved-PARP and caspase 3/7 activation, and reduced Bcl-2 and Mcl-1 expression confirm apoptosis induction. Preclinical in silico biopharmaceutical assessment of JB calculated rapid absorption and bioavailability >70%. Doses of 8-16 mg/kg JB were predicted to maintain unbound plasma concentrations >GI50 values in mice during efficacy studies. These findings advocate continued development of JB as a potential chemotherapeutic agent.


Cancer Lett


Cancer letters


Qazzaz ME,Raja VJ,Lim KH,Kam TS,Lee JB,Gershkovich P,Bradshaw TD




Has Abstract


2016-01-28 00:00:00














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    journal_title:Cancer letters

    pub_type: 杂志文章,评审


    authors: Bolignano D,Donato V,Lacquaniti A,Fazio MR,Bono C,Coppolino G,Buemi M

    更新日期:2010-02-01 00:00:00

  • Azelaic acid as a competitive inhibitor of thioredoxin reductase in human melanoma cells.

    abstract::Azelaic acid has been shown to inhibit thioredoxin reductase (TR) at the surface of guinea pig and human skin, on cultures of human keratinocytes, melanocytes, melanoma cells, murine melanoma cells (Cloudman S91), and on purified enzymes from Escherichia coli, rat liver, and human melanoma. Human melanoma cells are mo...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Schallreuter KU,Wood JM

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    abstract::In order to understand the differences and similarities between tumorigenic and non-tumorigenic HeLaxhuman fibroblast hybrids, gene expression profiles were examined with synthetic oligonucleotide arrays containing nearly 7000 gene probe sets. We used two pairs of genetically related hybrids, each pair representing in...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Nishizuka S,Winokur ST,Simon M,Martin J,Tsujimoto H,Stanbridge EJ

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  • Enhancement by antisense oligonucleotides to NF-kappaB of the differentiation of HL-60 promyelocytic leukemia cells induced by vitamin D3.

    abstract::We have demonstrated previously that a phosphorothioate antisense oligonucleotide to the p65 subunit of the inducible transcription factor NF-kappaB produced rapid changes in the expression of leukocyte integrin CD11b (Mo 1) and in the adhesion of dimethylsulfoxide (DMSO)-differentiated HL-60 cells stimulated by 12-O-...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Sokoloski JA,Narayanan R,Sartorelli AC

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  • The expression and function of miRNA-451 in non-small cell lung cancer.

    abstract::miRNAs are small, non-coding RNAs that negatively regulate gene expression at the post-transcriptional and translational levels. miRNA-451 was previously reported to be down-regulated in gastric and colorectal cancers. Here, we showed that miRNA-451 expression decreased in non-small cell lung cancer (NSCLC) tissues an...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Wang XC,Tian LL,Jiang XY,Wang YY,Li DG,She Y,Chang JH,Meng AM

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  • Src inhibitor dasatinib inhibits growth of breast cancer cells by modulating EGFR signaling.

    abstract::EGF-receptor family members (EGFRs) as well as c-Src are over expressed in approximately 70% of breast cancer, and in most of the tumors c-Src is co-over expressed with at least one of the EGFRs, suggesting that they may interact functionally and play a role in the development and progression of the malignancy. We hyp...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Nautiyal J,Majumder P,Patel BB,Lee FY,Majumdar AP

    更新日期:2009-10-08 00:00:00

  • Jade family PHD finger 3 (JADE3) increases cancer stem cell-like properties and tumorigenicity in colon cancer.

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    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Jian Y,Wang M,Zhang Y,Ou R,Zhu Z,Ou Y,Chen X,Liang X,Ding Y,Song L,Xu X,Liao W

    更新日期:2018-08-01 00:00:00

  • Anti-tumor activity of non-steroidal anti-inflammatory drugs: cyclooxygenase-independent targets.

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    journal_title:Cancer letters

    pub_type: 杂志文章,评审


    authors: Liggett JL,Zhang X,Eling TE,Baek SJ

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    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Rho SB,Byun HJ,Park SY,Chun T

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  • ARF6, induced by mutant Kras, promotes proliferation and Warburg effect in pancreatic cancer.

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    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Liang C,Qin Y,Zhang B,Ji S,Shi S,Xu W,Liu J,Xiang J,Liang D,Hu Q,Ni Q,Yu X,Xu J

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  • Failure of phenethyl isothiocyanate to inhibit hamster tumorigenesis induced by N-nitrosobis(2-oxopropyl)amine when given during the post-initiation phase.

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    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Nishikawa A,Furukawa F,Kasahara K,Tanakamaru Z,Miyauchi M,Nakamura H,Ikeda T,Imazawa T,Hirose M

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    journal_title:Cancer letters

    pub_type: 杂志文章,评审


    authors: Zhou LQ,Li P,Cui XW,Dietrich CF

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  • Polymorphisms in the MDM2 promoter and risk of breast cancer: a case-control analysis in a Chinese population.

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    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Ma H,Hu Z,Zhai X,Wang S,Wang X,Qin J,Jin G,Liu J,Wang X,Wei Q,Shen H

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  • MnSOD polymorphism and breast cancer in a population-based case-control study.

    abstract::A polymorphism in the signal sequence (Ala-9Val) of the gene encoding the free radical-quenching manganese superoxide dismutase (MnSOD) has been reported to alter the risk for breast cancer. We evaluated this relationship in a population-based case-control study (476 breast cancer cases and 502 controls). Overall, rel...

    journal_title:Cancer letters

    pub_type: 杂志文章,多中心研究


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    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Cavazzoni A,Galetti M,Fumarola C,Alfieri RR,Roz L,Andriani F,Carbognani P,Rusca M,Sozzi G,Petronini PG

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  • Mechanisms of immune evasion of human neuroblastoma.

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    journal_title:Cancer letters

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    authors: Raffaghello L,Prigione I,Airoldi I,Camoriano M,Morandi F,Bocca P,Gambini C,Ferrone S,Pistoia V

    更新日期:2005-10-18 00:00:00

  • Characterization and utilization of two novel anti-erbB-2 monoclonal antibodies in detection of soluble ErbB-2 for breast cancer prognosis.

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    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Li P,Li Y,Li JY,Liu J

    更新日期:2003-04-25 00:00:00

  • Effects of naturally occurring antioxidants on combined 1,2-dimethylhydrazine- and 1-methyl-1-nitrosourea-initiated carcinogenesis in F344 male rats.

    abstract::The effects of treatment with naturally occurring antioxidants, selenium, beta-carotene, ferulic acid, esculin and eugenol during the promotional phase of tumor development were investigated in male F344 rats pre-treated with 1,2-dimethylhydrazine (DMH) and 1-methyl-1-nitrosourea (MNU). Animals were given 3 subcutaneo...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Imaida K,Hirose M,Yamaguchi S,Takahashi S,Ito N

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  • Induction of cytogenetic adaptive response of mouse bone marrow cells to radiation by therapeutic doses of bleomycin sulfate and actinomycin D as assayed by the micronucleus test.

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    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Mozdarani H,Saberi AH

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  • Point mutations at codon 12 of C-K-ras in human endometrial carcinomas.

    abstract::Samples of human endometrial carcinomas of ranging degree of histological differentiation, and normal endometrial tissues were screened for the presence of single site DNA mutations at codon 12 of the C-K-ras gene using oligonucleotide hybridisation of DNA amplified by the polymerase chain reaction (PCR). Two instance...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Lester DR,Cauchi MN

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    journal_title:Cancer letters

    pub_type: 杂志文章,评审


    authors: Miranda-Gonçalves V,Lameirinhas A,Henrique R,Baltazar F,Jerónimo C

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  • Cancer mortality and some socio economic correlates in Rosario, Argentina.

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    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Poletto L,Morini JC

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  • The aflatoxin-induced TP53 mutation at codon 249 (R249S): biomarker of exposure, early detection and target for therapy.

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    journal_title:Cancer letters

    pub_type: 杂志文章,评审


    authors: Gouas D,Shi H,Hainaut P

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  • Targeted MYCN expression affects cytotoxic potential of chemotherapeutic drugs in neuroblastoma cells.

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    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Paffhausen T,Schwab M,Westermann F

    更新日期:2007-05-18 00:00:00

  • P-glycoprotein expression by human colonic tumor cells influences the growth of tumor cells in vitro.

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    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Frommel TO

    更新日期:1995-08-01 00:00:00

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    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Park JS,Young Yoon S,Kim JM,Yeom YI,Kim YS,Kim NS

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    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Ikegawa T,Ushigome F,Koyabu N,Morimoto S,Shoyama Y,Naito M,Tsuruo T,Ohtani H,Sawada Y

    更新日期:2000-11-10 00:00:00

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    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Shibata Y,Matsumura A,Yoshida F,Yamamoto T,Nakai K,Nose T,Sakata I,Nakajima S

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  • Resistance factors in colon cancer tissue and the adjacent normal colon tissue: glutathione S-transferases alpha and pi, glutathione and aldehyde dehydrogenase.

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    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Hengstler JG,Böttger T,Tanner B,Dietrich B,Henrich M,Knapstein PG,Junginger T,Oesch F

    更新日期:1998-06-05 00:00:00

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    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Von Tungeln LS,Bucci TJ,Hart RW,Kadlubar FF,Fu PP

    更新日期:1996-07-12 00:00:00