当前位置： SCI文献检索 > CANCER LETTERS期刊下所有文献 > Compromised Fanconi anemia response due to BRCA1 deficiency in cisplatin-sensitive head and neck cancer cell lines.

Compromised Fanconi anemia response due to BRCA1 deficiency in cisplatin-sensitive head and neck cancer cell lines.

Abstract：

:Head and neck cancers are commonly treated with the DNA-damaging agent cisplatin. While many tumors respond well to cisplatin treatment, some do not. The mechanism for this differential sensitivity of head and neck tumors to cisplatin is not understood in detail. In this study, we explored whether the functional status of the Fanconi anemia and BRCA pathway (FA/BRCA) would predict cisplatin sensitivity in head and neck cancer cells. The FA/BRCA pathway is critical for the orchestration of the cellular response to cisplatin and other DNA cross-linking agents. It was found that three out of four cisplatin-sensitive head and neck cancer cell lines showed defective formation of FANCD2 nuclear foci while all four cisplatin-resistant cell lines tested were proficient in FANCD2 foci formation following cisplatin treatment. The defect in FANCD2 foci formation in the cisplatin-sensitive cell lines was not due to defective monoubiquitylation of FANCD2 but appeared to be due to reduced expression or defective function of BRCA1 since expression of exogenous BRCA1 restored the ability of these cells to induce FANCD2 foci following cisplatin treatment and enhanced cisplatin resistance. These results suggest a possible role for BRCA1 in modulating cisplatin sensitivity in head and neck cancer cells.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Burkitt K,Ljungman M

doi

10.1016/j.canlet.2007.01.017

subject

Has Abstract

pub_date

2007-08-08 00:00:00

pages

131-7

issue

1

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(07)00036-5

journal_volume

253

pub_type

杂志文章

相关文献

CANCER LETTERS文献大全
  • Preclinical comparison of regorafenib and sorafenib efficacy for hepatocellular carcinoma using multimodality molecular imaging.

    abstract：:Sorafenib has been used as a clinical targeted therapy for hepatocellular carcinoma (HCC) for more than a decade. In 2017, regorafenib was approved for HCC treatment and has since been reported to prolong the survival of advanced HCC patients after treatment failure with sorafenib. However, there has been no direct sy...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2019.03.037

    authors： Liu S,Du Y,Ma H,Liang Q,Zhu X,Tian J

    更新日期：2019-07-01 00:00:00

  • Mucin expression in mucinous carcinoma and other invasive carcinomas of the breast.

    abstract：:To investigate mucin expression in breast cancer, immunohistochemical staining was performed on 30 mucinous carcinomas and 95 non-mucinous invasive carcinomas. MUC2 expression was detected in all mucinous carcinomas, but only in 11.1% of invasive ductal carcinomas, and in none of the invasive lobular carcinomas and me...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(99)00161-5

    authors： Chu JS,Chang KJ

    更新日期：1999-07-19 00:00:00

  • Influence of supplemental glutathione on selenite-mediated growth inhibition of canine mammary cells.

    abstract：:Present studies show the in vitro addition of glutathione (GSH) can significantly alter selenite induced growth inhibition of mammary tumor cell line 13 (CMT-13). Preincubation with 100 microM GSH for 24 h partially prevented the growth inhibition caused by 12.6 microM selenite. Pre-incubation with 100 microM GSH for ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(91)90213-2

    authors： Kuchan MJ,Milner JA

    更新日期：1991-05-01 00:00:00

  • The effects of ellagic acid and 13-cis-retinoic acid on N-nitrosobenzylmethylamine-induced esophageal tumorigenesis in rats.

    abstract：:Ellagic acid (EA) and 13-cis-retinoic acid (CRA), both alone and in combination, were tested for their ability to inhibit N-nitrosobenzylmethylamine-induced tumors in the rat esophagus. Groups of male rats were fed AIN-76A diet containing EA (4 g/kg), CRA (240 mg/kg), or a combination of EA and CRA (4 g/kg and 240 mg/...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(91)90085-v

    authors： Daniel EM,Stoner GD

    更新日期：1991-02-01 00:00:00

  • Hepatocyte growth factor (HGF) upregulates heparanase expression via the PI3K/Akt/NF-κB signaling pathway for gastric cancer metastasis.

    abstract：:Heparanase (HPA) is an endoglucuronidase that can promote the shedding of associated cytokines in several types of tumors. However, little is known about what controls the expression of HPA or its role in gastric cancer. In this study, we report for the first time that HGF regulates HPA expression to promote gastric c...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2015.02.043

    authors： Hao NB,Tang B,Wang GZ,Xie R,Hu CJ,Wang SM,Wu YY,Liu E,Xie X,Yang SM

    更新日期：2015-05-28 00:00:00

  • gamma-Glutamyltranspeptidase activity in a human pancreatic cancer cell line (HPC-Y1) in serum-free chemically defined medium.

    abstract：:gamma-Glutamyltranspeptidase (gamma-GTP) activity was found in a human pancreatic cancer cell line, HPC-Y1, cultivated in a serum-free chemically defined medium. The gamma-GTP stained in the cytoplasms as fine granules and was produced constantly in a protein-free chemically defined medium. The detergent- or protease-...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(84)80037-3

    authors： Yamaguchi N,Sugimoto M,Kawai K

    更新日期：1984-12-01 00:00:00

  • Binding of 1-nitro[14C]pyrene to DNA and protein in cultured lung macrophages and respiratory tissues.

    abstract：:Binding of 1-nitro[14C]pyrene (1-NP) or its metabolites to cellular DNA and protein in cultures of rabbit alveolar macrophages and lung and tracheal tissues was examined. DNA binding was highest in tracheal tissue (136.9 +/- 18.3 pmol 1-NP/mg DNA). DNA binding in macrophages and lung tissue was one-fifth of the level ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(83)90091-5

    authors： King LC,Jackson M,Ball LM,Lewtas J

    更新日期：1983-07-01 00:00:00

  • Influence of tocopherol on tumour cell oxygenation.

    abstract：:Tocopherol, a well known tissue anti-oxidant, given before local X-ray irradiation of 2 transplantable rat tumours was previously found to increase significantly the effect of irradiation. In the present study tocopherol did not influence the development of tumour necroses during growth of a transplantable rat hepatom...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(78)80037-8

    authors： Kågerud A,Klintenberg C,Lund N,Peterson HI

    更新日期：1978-10-01 00:00:00

  • Induction of telomerase activity during an early burst of proliferation in pancreatic regeneration.

    abstract：:Telomerase activity (TA) and telomerase reverse transcriptase (rTERT) were investigated in Sprague-Dawley rats, killed at 6 and 12 h, and 1, 2, 3, 7, and 14 days after 90% pancreatectomy (px), by TRAPeze enzyme-linked immunosorbent assay telomerase detection and reverse transcriptase-polymerase chain reaction. TA incr...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(02)00320-8

    authors： Oh BK,Seong JK,Lee JE,Chae KJ,Roh KJ,Park C,Park YN

    更新日期：2002-12-01 00:00:00

  • Human papillomavirus, cytomegalovirus and herpes simplex virus infections for cervical cancer in Taiwan.

    abstract：:Previously, we had reviewed 43 cases of invasive cancers, adenosquamous cell carcinoma and adenocarcinoma for HPV type infections. With the same cases we extended the investigation to cytomegalovirus (CMV) and herpes simplex virus (HSV) infections. Results show that the prevalence of CMV and HSV infections from these ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(97)00312-1

    authors： Han CP,Tsao YP,Sun CA,Ng HT,Chen SL

    更新日期：1997-12-09 00:00:00

  • Inhibition of NMU-induced mammary tumorigenesis by dietary soy.

    abstract：:We previously demonstrated that female Sprague-Dawley rats fed AIN-93G diets containing soy protein isolate (SPI+) had lower DMBA-induced mammary tumor incidence than those fed diets containing casein (CAS), due partly to altered Phase I metabolism with soy. Here, we evaluated the tumor protective effects of these sam...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2004.11.009

    authors： Simmen RC,Eason RR,Till SR,Chatman L Jr,Velarde MC,Geng Y,Korourian S,Badger TM

    更新日期：2005-06-16 00:00:00

  • Induction of differentiation of human promyelocytic leukemia cells (HL-60) by arginase.

    abstract：:Human promyelocytic leukemia cells (HL-60) were found to be induced by dimethylsulfoxide and several other compounds to phagocytize, reduce NBT dye, and change into forms that were morphologically similar to granulocytes and macrophages. Arginase also induced these differentiation-associated properties of the cells. T...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(80)90044-0

    authors： Honma Y,Fujita Y,Okabe-Kado J,Kasukabe T,Hozumi M

    更新日期：1980-10-01 00:00:00

  • Metastasis of breast tumor cells to brain is suppressed by targeting RLIP alone and in combination with 2'-Hydroxyflavanone.

    abstract：:Brain metastasis is an important cause of morbidity and mortality in cancer-patients. Breast tumor cells frequently metastasize to brain and initiate severe therapeutic complications. In the present study, we evaluated the anti-metastatic effects of 2'-hydroxyflavanone (2HF) alone and in combination with RLIP targeted...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2018.09.015

    authors： Singhal J,Singhal P,Horne D,Salgia R,Awasthi S,Singhal SS

    更新日期：2018-12-01 00:00:00

  • Inhibition of growth and development of the transplantable C-6 glioma cells inoculated in rats by retinoids and carotenoids.

    abstract：:Experimental data were provided to demonstrate the inhibitory effects of retinoids (retinal, retinoic acid, retinyl acetate and retinyl palmitate) and carotenoids (beta-carotene, lycopene and crocetin) on the growth and development of the C-6 glioma cells inoculated in rats. In the pretreatment experiments, most of th...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(89)90050-5

    authors： Wang CJ,Chou MY,Lin JK

    更新日期：1989-11-30 00:00:00

  • USP22 promotes resistance to EGFR-TKIs by preventing ubiquitination-mediated EGFR degradation in EGFR-mutant lung adenocarcinoma.

    abstract：:As a newly discovered deubiquitinating enzyme, ubiquitin-specific protease 22 (USP22) is predictive of therapeutic outcomes in individual cancer patients. However, its clinical effects on malignancy and its roles in conferring resistance to EGFR-TKIs (epidermal growth factor receptor-tyrosine kinase inhibitors) in lun...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2018.07.002

    authors： Zhang H,Han B,Lu H,Zhao Y,Chen X,Meng Q,Cao M,Cai L,Hu J

    更新日期：2018-10-01 00:00:00

  • Effects of the synthetic trypsin inhibitor camostate on the development of N-nitrosobis(2-oxopropyl)amine-induced pancreatic lesions in hamsters.

    abstract：:Trypsin inhibitors have been shown to promote pancreatic growth as well as the development of pancreatic tumours in rats. The present study was carried out to examine the effects of the synthetic trypsin inhibitor camostate on the growth of the pancreas and on the development of pancreatic preneoplastic and neoplastic...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(91)90115-x

    authors： Meijers M,van Garderen-Hoetmer A,Lamers CB,Rovati LC,Jansen JB,Woutersen RA

    更新日期：1991-12-01 00:00:00

  • Proto-oncogene ACTR/AIB1 promotes cancer cell invasion by up-regulating specific matrix metalloproteinase expression.

    abstract：:Overexpression of ACTR/AIB1 is frequently found in different cancers with distant metastasis. To address its possible involvement in tumor metastasis, we performed invasion assays to examine the effect of ACTR alteration on the invasiveness of breast cancer cells (MDA-MB-231 or T-47D) and found that high levels of ACT...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2007.11.013

    authors： Li LB,Louie MC,Chen HW,Zou JX

    更新日期：2008-03-08 00:00:00

  • Metabolic activation of the tumorigenic pyrrolizidine alkaloid, monocrotaline, leading to DNA adduct formation in vivo.

    abstract：:Monocrotaline is a representative naturally occurring genotoxic pyrrolizidine alkaloid. Metabolism of monocrotaline by liver microsomes of F344 female rats generated (+/-)6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine (DHP) and monocrotaline-N-oxide as major metabolites. Metabolism in the presence of triacetylea...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2004.11.039

    authors： Wang YP,Yan J,Beger RD,Fu PP,Chou MW

    更新日期：2005-08-08 00:00:00

  • Antitumor activity of interleukin 12 against interleukin 2-transduced mouse glioma cells.

    abstract：:We subcutaneously inoculated parental and glioma cells genetically engineered to express interleukin-2 (SR/IL-2) into syngeneic mice. The tumor growth of the transfectants was slower than that of the parental cells. We then stereotactically inoculated transfectants into the brains of mice. The survival of the mice inj...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(98)00268-7

    authors： Kikuchi T,Joki T,Akasaki Y,Abe T,Ohno T

    更新日期：1999-01-08 00:00:00

  • S/RV Cri-ba, a hairless mouse strain sensitive to skin tumorigenesis by suboptimal doses of 7,12-dimethylbenz[a]anthracene, initiation-promotion and two stage promotion protocols.

    abstract：:Susceptibility of hairless inbred S/RV Cri-ba or Bare mice to skin tumor development with suboptimal doses of 7,12-dimethylbenz[a]anthracene (DMBA), DMBA-TPA two stage protocol and two stage promotion using 12-O-tetradecanoylphorbol-13-acetate (TPA) as sub-stage 1 promoter and mezerein (MEZ) or phorbol retinoate aceta...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(90)90078-c

    authors： Bhisey RA,Veturkar PL

    更新日期：1990-06-30 00:00:00

  • Utilization of blood analyses to evaluate metabolic changes in control and 1,2-dimethylhydrazine-treated adult male fischer rats.

    abstract：:The synthetic compound 1,2-dimethylhydrazine is employed in carcinogenesis studies because of its reliable and specific ability to produce colon tumors in rodents. Male Fischer rats were treated at 7 weeks of age with a single oral dose of 1,2-dimethylhydrazine (35 mg/kg) and examined at autopsy 1.5 years later when t...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(81)90008-2

    authors： Southern JT,Schiller CM

    更新日期：1981-10-01 00:00:00

  • Aiming at the sweet side of cancer: aberrant glycosylation as possible target for personalized-medicine.

    abstract：:One of the frontiers in cancer personalized-medicine aims at glycosylation. Cells are covered with a dense sugar coat of glycolipids, glycoproteins and free glycans. In cancer, the characteristic cell surface glycosylation is frequently transformed due to altered expression of glycan-modifying enzymes. This often lead...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2013.10.005

    authors： Padler-Karavani V

    更新日期：2014-09-28 00:00:00

  • Ultrasound-induced apoptosis in the presence of Sonazoid and associated alterations in gene expression levels: a possible therapeutic application.

    abstract：:Ultrasound (US) has been shown to induce apoptosis and cell lysis in cancer cells. In this study, we report on the potential of using Sonazoid, a new echo-contrast agent, that is chemically more stable and US-resistant in combination with US in cancer therapy. The biological effects and their mechanisms in the presenc...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2009.06.029

    authors： Furusawa Y,Zhao QL,Hassan MA,Tabuchi Y,Takasaki I,Wada S,Kondo T

    更新日期：2010-02-01 00:00:00

  • Gastrin acting on the cholecystokinin2 receptor induces cyclooxygenase-2 expression through JAK2/STAT3/PI3K/Akt pathway in human gastric cancer cells.

    abstract：:Gastrin, cholecystokinin2 receptor (CCK2R), and cyclooxygenase-2 (COX-2) have been implicated in the carcinogenesis and progression of gastric cancer. Our study demonstrated that antagonist or siRNA against CCK2R blocked amidated gastrin (G17)-induced activation of STAT3 and Akt in gastric cancer cell lines. G17-incre...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2012.12.030

    authors： Xu W,Chen GS,Shao Y,Li XL,Xu HC,Zhang H,Zhu GQ,Zhou YC,He XP,Sun WH

    更新日期：2013-05-10 00:00:00

  • Inhibition of 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary tumorigenesis and of in vivo formation of mammary DMBA-DNA adducts by rosemary extract.

    abstract：:The effect of dietary intake of an extract of the spice plant Rosmarinus officinalis L. on 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary tumorigenesis and on the in vivo formation of mammary DMBA-DNA adducts was evaluated. Supplementation of a semi-purified diet with 1.0% (by wt.) rosemary extract resulted in ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(91)90224-6

    authors： Singletary KW,Nelshoppen JM

    更新日期：1991-11-01 00:00:00

  • Inhibition of development of preneoplastic lesions in the livers of rats fed a weakly carcinogenic environmental contaminant.

    abstract：:The effects of di(2-ethylhexyl)phthalate (DEHP), a widely used plasticizer and environmental contaminant, on the emergence of gamma-glutamyltrans-peptidase positive (GGT+) preneoplastic foci in the liver was investigated. Sprague--Dawley male rats initiated with diethylnitrosamine (DEN) following partial hepatectomy w...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(83)90049-6

    authors： Deangelo AB,Garrett CT

    更新日期：1983-09-01 00:00:00

  • Two repeated low doses of doxorubicin are more effective than a single high dose against tumors overexpressing P-glycoprotein.

    abstract：:Standard chemotherapeutic protocols, based on maximum tolerated doses, do not prevent nor overcome chemoresistance caused by the efflux transporter P-glycoprotein (Pgp). We compared the effects of two consecutive low doses versus a single high dose of doxorubicin in drug-sensitive Pgp-negative and drug-resistant Pgp-p...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2015.02.008

    authors： Riganti C,Gazzano E,Gulino GR,Volante M,Ghigo D,Kopecka J

    更新日期：2015-05-01 00:00:00

  • RETRACTED: MiR-143 inhibits tumor cell proliferation and invasion by targeting STAT3 in esophageal squamous cell carcinoma.

    abstract：:This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the Editor in Chief. The term miR-143 has been used instead of the term miR-143* in the introduction and discussion which is misleading...

    journal_title：Cancer letters

    pub_type： 杂志文章,收录出版

    doi：10.1016/j.canlet.2016.01.023

    authors： Liu J,Mao Y,Zhang D,Hao S,Zhang Z,Li Z,Li B

    更新日期：2016-04-01 00:00:00

  • Isorhamnetin augments the anti-tumor effect of capecitabine through the negative regulation of NF-κB signaling cascade in gastric cancer.

    abstract：:Development of drug resistance to standard chemotherapy is a common phenomenon that leads to poor prognosis in patients. Thus, novel agents that can attenuate chemoresistance are urgently needed. Therefore, we analyzed whether isorhamnetin (IH), a 3'-O-methylated metabolite of quercetin, can enhance the potential effi...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2015.03.033

    authors： Manu KA,Shanmugam MK,Ramachandran L,Li F,Siveen KS,Chinnathambi A,Zayed ME,Alharbi SA,Arfuso F,Kumar AP,Ahn KS,Sethi G

    更新日期：2015-07-10 00:00:00

  • Low-frequency electromagnetic radiation enhances the induction of rat mammary tumors by nitrosomethyl urea.

    abstract：:Low-frequency electromagnetic fields enhance the induction of mammary gland tumors in rats using nitrosomethyl urea. The incidence of tumors depended on the duration of exposure to static (dc) and variable (ac) magnetic fields. Variable magnetic fields induced mammary gland cancer much more frequently than static ones...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(91)90079-w

    authors： Beniashvili DS,Bilanishvili VG,Menabde MZ

    更新日期：1991-12-09 00:00:00