当前位置： SCI文献检索 > CANCER LETTERS期刊下所有文献 > Proto-oncogene ACTR/AIB1 promotes cancer cell invasion by up-regulating specific matrix metalloproteinase expression.

Proto-oncogene ACTR/AIB1 promotes cancer cell invasion by up-regulating specific matrix metalloproteinase expression.

Abstract：

:Overexpression of ACTR/AIB1 is frequently found in different cancers with distant metastasis. To address its possible involvement in tumor metastasis, we performed invasion assays to examine the effect of ACTR alteration on the invasiveness of breast cancer cells (MDA-MB-231 or T-47D) and found that high levels of ACTR are required for their strong invasiveness. Molecular analysis indicates that ACTR functions as a coactivator of AP-1 to up-regulate the expression of matrix metalloproteinases such as MMP-7 and MMP-10 and reduce cell adhesion to specific extracellular matrix proteins. These novel findings provide a mechanistic link between ACTR and MMPs, and suggest that ACTR may also play an important role in cancer progression by facilitating tumor invasion.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Li LB,Louie MC,Chen HW,Zou JX

doi

10.1016/j.canlet.2007.11.013

subject

Has Abstract

pub_date

2008-03-08 00:00:00

pages

64-73

issue

1

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(07)00542-3

journal_volume

261

pub_type

杂志文章

相关文献

CANCER LETTERS文献大全
  • Pediatric human immunodeficiency virus infection and cancer in the highly active antiretroviral treatment (HAART) era.

    abstract：:Highly active antiretroviral therapy (HAART) changed the natural history of pediatric HIV infection. This review focuses on trends of HIV-associated cancers in childhood in the HAART era and analyses potential pathogenetic mechanisms. HAART reduced AIDS-defined-malignancies (ADM), but incidence of several non-ADM is i...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2014.02.002

    authors： Chiappini E,Berti E,Gianesin K,Petrara MR,Galli L,Giaquinto C,de Martino M,De Rossi A

    更新日期：2014-05-28 00:00:00

  • Loss of heterozygosity and the smoking index increase with decrease in differentiation of lung adenocarcinomas: etiologic implications.

    abstract：:To better understand causative relations of smoking to lung adenocarcinomas, the frequency of loss of heterozygosity (LOH) of all autosomal chromosomes was compared among the three grades of histological differentiation with 119 pulmonary adenocarcinomas (AC) and 41 squamous cell carcinomas (SCC), using Southern blott...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(02)00383-x

    authors： Ishikawa Y,Furuta R,Miyoshi T,Satoh Y,Okumura S,Nakagawa K,Tsuchiya E

    更新日期：2002-12-10 00:00:00

  • Volatilization of mutagens from beef during cooking.

    abstract：:The process of cooking beef substances which are mutagenic in the Ames Salmonella/microsome bioassay [1,2]. In this study, the formation and disposition of basic mutagens produced by cooking beef at different temperatures were examined. Mutagenic activity increased exponentially with cooking temperature between 137 de...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(79)90007-7

    authors： Rappaport SM,McCartney MC,Wei ET

    更新日期：1979-12-01 00:00:00

  • Rapid induction of mammary cancer by repeated subcutaneous injection of the trans-3,4-dihydrodiol of 7,12-dimethylbenz[a]anthracene in the female Sprague-Dawley rat.

    abstract：:The oral administration of a single 20mg dose of 7,12-dimethylbenz[a]anthracene regularly and rapidly induces mammary cancer in 50 day-old Sprague-Dawley female rats [Experimental Leukemia and Mammary Cancer, 1979, p. 74]. Several mechanisms by which 7,12-dimethylbenz[a]anthracene induces mammary cancer have been prop...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2004.07.039

    authors： Horn J,Lehner AF,Flesher JW

    更新日期：2005-04-08 00:00:00

  • Slight promotion effects of intermittent administration of testosterone propionate and/or diethylstilbestrol on 3,2'-dimethyl-4-aminobiphenyl-initiated rat prostate carcinogenesis.

    abstract：:In order to determine the effects of intermittent hormonal manipulation on the promotion stage of rat prostate carcinogenesis, testosterone and/or estrogen were administered to F344 rats for 40 weeks after 20-weeks treatment with the prostate carcinogen, 3,2'-dimethyl-4-aminobiphenyl. For this purpose testosterone pro...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(97)00390-x

    authors： Cui L,Mori T,Takahashi S,Imaida K,Akagi K,Yada H,Yaono M,Shirai T

    更新日期：1998-01-09 00:00:00

  • BH3 mimetics potentiate pro-apoptotic activity of encorafenib in BRAFV600E melanoma cells.

    abstract：:BRAFV600- and MEK1/2-targeting therapies rarely produce durable response in melanoma patients. We investigated five BRAFV600E melanoma cell lines derived from drug-naïve tumor specimens to assess cell death response to encorafenib (Braftovi), a recently FDA-approved BRAFV600 inhibitor. Drug-naïve cell lines (i) did no...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2020.11.036

    authors： Hartman ML,Gajos-Michniewicz A,Talaj JA,Mielczarek-Lewandowska A,Czyz M

    更新日期：2021-02-28 00:00:00

  • Difference of caveolin-1 expression pattern in human lung neoplastic tissue. Atypical adenomatous hyperplasia, adenocarcinoma and squamous cell carcinoma.

    abstract：:Caveolin-1 has been implicated in cellular transformation and tumorigenesis. We assessed lung cancer specimens for caveolin-1 expression immunohistochemistry. A majority of the cell types in the lung and the bronchial epithelium normally exhibited positive staining for caveolin-1. In adenocarcinomas (ADs) of positive ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2004.04.017

    authors： Kato T,Miyamoto M,Kato K,Cho Y,Itoh T,Morikawa T,Okushiba S,Kondo S,Ohbuchi T,Katoh H

    更新日期：2004-10-08 00:00:00

  • Oncolytic adenovirus expressing relaxin (YDC002) enhances therapeutic efficacy of gemcitabine against pancreatic cancer.

    abstract：:Pancreatic cancer is a highly lethal disease for which limited therapeutic options are available. Pancreatic cancer exhibits a pronounced collagen-rich stromal reaction, which induces chemoresistance by inhibiting drug diffusion into the tumor. Complementary treatment with oncolytic virus such as an oncolytic adenovir...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2017.03.009

    authors： Jung KH,Choi IK,Lee HS,Yan HH,Son MK,Ahn HM,Hong J,Yun CO,Hong SS

    更新日期：2017-06-28 00:00:00

  • Timing of N-methyl-N-nitrosourea administration affects gastric carcinogenesis in Mongolian gerbils infected with Helicobacter pylori.

    abstract：:In Mongolian gerbils, the gastric mucosa shows dramatic changes after Helicobacter pylori inoculation. The influence of the timing of N-methyl-N-nitrosourea (MNU) administration after H. pylori inoculation on gastric carcinogenesis was investigated. Ninety-two gerbils were divided into four groups. One group was given...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(00)00571-1

    authors： Maruta F,Sugiyama A,Ishida K,Ikeno T,Murakami M,Kawasaki S,Ota H,Tatematsu M,Katsuyama T

    更新日期：2000-11-10 00:00:00

  • Feedback loop between p66(Shc) and Nrf2 promotes lung cancer progression.

    abstract：:p66(Shc), one of the SHC1 gene encoding proteins, promotes cell death and reports cell anchorage status, mediating anoikis in vitro and functioning as a metastasis suppressor in vivo. However, very little is known about p66(Shc) gene regulation in cancer cells. Here, we show that methylation of a specific CpG site in ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2013.05.016

    authors： Du W,Jiang Y,Zheng Z,Zhang Z,Chen N,Ma Z,Yao Z,Terada L,Liu Z

    更新日期：2013-08-28 00:00:00

  • Expression profiling identifies epoxy anthraquinone derivative as a DNA topoisomerase inhibitor.

    abstract：:To discover novel drugs for neuroblastoma treatment, we have previously screened a panel of drugs and identified 30 active agents against neuroblastoma cells. Here we performed microarray gene expression analysis to monitor the impact of these agents on a neuroblastoma cell line and used the connectivity map (cMAP) to...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2010.01.004

    authors： Gheeya J,Johansson P,Chen QR,Dexheimer T,Metaferia B,Song YK,Wei JS,He J,Pommier Y,Khan J

    更新日期：2010-07-01 00:00:00

  • Synergistic inhibition of human gastric carcinoma cell growth by 1-beta-D-arabinofuranosylcytosine and hydroxyurea or 2'-deoxyguanosine in vitro.

    abstract：:The cytotoxicity of 1-beta-D-arabinofuranosylcytosine (ara-C) in combination with hydroxyurea (HU) or 2'-deoxyguanosine (GdR) on human gastric carcinoma MK-1 cells and colon carcinoma HT-15 cells was studied. Synergistic interaction between ara-C and HU on MK-1 cells and HT-15 cells, or ara-C and GdR on MK-1 cells was...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(92)90264-v

    authors： Matsumoto M,Kawahara T,Tsuda M,Ohkubo T,Kamiguchi H,Yamamura M

    更新日期：1992-04-30 00:00:00

  • NF-kappaB modulation and ionizing radiation: mechanisms and future directions for cancer treatment.

    abstract：:NF-kappaB transcription factor regulates important cellular processes ranging from establishment of the immune and inflammatory responses to regulation of cell proliferation or apoptosis, through the induction of a large array of target genes. NF-kappaB is now considered as an important actor in the tumorigenic proces...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2005.01.022

    authors： Magné N,Toillon RA,Bottero V,Didelot C,Houtte PV,Gérard JP,Peyron JF

    更新日期：2006-01-18 00:00:00

  • MicroRNAs and cancer stem cells: therapeutic approaches and future perspectives.

    abstract：:Cancer stem cells (CSCs) are a sub-population of cancer cells that possess characteristics associated with normal stem cells but with the peculiarity that they are tumourigenic. This property allows them to persist in the tumour population, causing relapse and metastasis by giving rise to new tumours. Accordingly, if ...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2012.04.020

    authors： Leal JA,Lleonart ME

    更新日期：2013-09-10 00:00:00

  • Metabolic adaptation in hypoxia and cancer.

    abstract：:The ability of tumor cells to adapt to changes in oxygen tension is essential for tumor development. Low oxygen concentration influences cellular metabolism and, thus, affects proliferation, migration, and invasion. A focal point of the cell's adaptation to hypoxia is the transcription factor HIF1α (hypoxia-inducible ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2020.12.020

    authors： Paredes F,Williams HC,San Martin A

    更新日期：2021-01-11 00:00:00

  • Mechanism of uptake of sulfonated metallophthalocyanines by cultured mammalian cells.

    abstract：:The uptake of several metallophthalocyanine tetrasulfonates by cultured Chinese hamster cells was studied. Uranyl- and chloraluminium were taken up at the highest rate followed by Ni-, Zn-, Cu-, Co- and dichlorosilicon-phthalocyanine tetrasulfonate. The uptake from the growth medium containing 10% serum in which only ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(87)90217-5

    authors： Ben-Hur E,Siwecki JA,Newman HC,Crane SW,Rosenthal I

    更新日期：1987-12-01 00:00:00

  • Rafoxanide, an organohalogen drug, triggers apoptosis and cell cycle arrest in multiple myeloma by enhancing DNA damage responses and suppressing the p38 MAPK pathway.

    abstract：:Rafoxanide is used in veterinary medicine for the treatment of fascioliasis. We previously repositioned the drug as the inhibitor of B-Raf V600E, but its anti-tumor effect in human cancer has never been reported. In this study, we investigated the effects of rafoxanide in multiple myeloma (MM) in vitro and in vivo. We...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2018.12.014

    authors： Xiao W,Xu Z,Chang S,Li B,Yu D,Wu H,Xie Y,Wang Y,Xie B,Sun X,Kong Y,Lan X,Bu W,Chen G,Gao L,Wu X,Shi J,Zhu W

    更新日期：2019-03-01 00:00:00

  • Lobatin B inhibits NPM/ALK and NF-κB attenuating anaplastic-large-cell-lymphomagenesis and lymphendothelial tumour intravasation.

    abstract：:An apolar extract of the traditional medicinal plant Neurolaena lobata inhibited the expression of the NPM/ALK chimera, which is causal for the majority of anaplastic large cell lymphomas (ALCLs). Therefore, an active principle of the extract, the furanoheliangolide sesquiterpene lactone lobatin B, was isolated and te...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2014.11.019

    authors： Kiss I,Unger C,Huu CN,Atanasov AG,Kramer N,Chatruphonprasert W,Brenner S,McKinnon R,Peschel A,Vasas A,Lajter I,Kain R,Saiko P,Szekeres T,Kenner L,Hassler MR,Diaz R,Frisch R,Dirsch VM,Jäger W,de Martin R,Bochkov

    更新日期：2015-01-28 00:00:00

  • Inhibition of azoxymethane-induced intestinal cancer by disulfiram.

    abstract：:Sprague--Dawley rats, both intact and colostomized animals, were given 24 weekly injections of azoxymethane. Rats were fed either Rat Purina Chow or the same diet plus 0.25% disulfiram. In the intact animals, disulfiram reduced tumors from an average of 6.3 to 0.95. The number of rats developing tumors was reduced fro...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(78)80050-0

    authors： Nigro ND,Campbell RL

    更新日期：1978-08-01 00:00:00

  • Endothelin-1 promotes cell survival in renal cell carcinoma through the ET(A) receptor.

    abstract：:Endothelin-1 (ET-1) is a potent vasoconstrictor that has been shown to significantly impact many benign and malignant tissues by signaling through its two cognate receptors: ET(A) and ET(B). As ET-1 has a role in both normal and diseased kidney, we initiated studies to investigate endothelin axis expression and functi...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2006.02.007

    authors： Pflug BR,Zheng H,Udan MS,D'Antonio JM,Marshall FF,Brooks JD,Nelson JB

    更新日期：2007-02-08 00:00:00

  • Cytotoxic effects of the components in heat-treated mistletoe (Viscum album).

    abstract：:Major cytotoxic components were fractionated from Korean mistletoe and the changes of their cytotoxic effects caused by heat treatment were investigated. The high cytotoxicity of isolated lectin I completely disappeared by heating for 30 min. The fractions of viscotoxins and alkaloids maintained their activities even ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(99)00043-9

    authors： Park JH,Hyun CK,Shin HK

    更新日期：1999-05-24 00:00:00

  • Evolving significance of prognostic markers associated with new treatment strategies in neuroblastoma.

    abstract：:The striking differences in the natural history of clinical subgroups of neuroblastoma (NB), and the evolving therapeutic approaches for each, makes it imperative for prognostic markers to be reevaluated within individual clinical categories. At least one third of NB cases present without distant metastasis and cytoto...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/s0304-3835(03)00094-6

    authors： Mora J,Gerald WL,Cheung NK

    更新日期：2003-07-18 00:00:00

  • Topical and intratumoral photodynamic therapy with 5-aminolevulinic acid in a subcutaneous murine mammary adenocarcinoma.

    abstract：:One of the most promising substances used in photodynamic therapy (PDT) is 5-aminolevulinic acid (ALA), which induces endogenous synthesis and accumulation of porphyrins in malignant cells. In this paper we have shown that both topical and intratumoral administration of ALA in a subcutaneously implanted mammary carcin...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(99)00079-8

    authors： Casas A,Fukuda H,Meiss R,Batlle AM

    更新日期：1999-07-01 00:00:00

  • Peritoneal mesothelium promotes the progression of ovarian cancer cells in vitro and in a mice xenograft model in vivo.

    abstract：:The role of mesothelial cells in the intraperitoneal spread of ovarian cancer is still elusive. In particular, it is unclear whether these cells constitute a passive barrier preventing cancer cell progression or perhaps act as an active promoter of this process. In this report we show that omental human peritoneal mes...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2014.09.041

    authors： Mikuła-Pietrasik J,Sosińska P,Kucińska M,Murias M,Maksin K,Malińska A,Ziółkowska A,Piotrowska H,Woźniak A,Książek K

    更新日期：2014-12-28 00:00:00

  • Network-based cancer precision medicine: A new emerging paradigm.

    abstract：:The complex interactions in biological systems have been shown to affect the response to single-targeted therapies which were initially developed under the "reductionist paradigm" of cancer precision medicine. To address these fundamental challenges, great efforts have been dedicated from a network perspective to expl...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2019.05.015

    authors： Tan A,Huang H,Zhang P,Li S

    更新日期：2019-08-28 00:00:00

  • Repression of Mcl-1 and disruption of the Mcl-1/Bak interaction in myeloma cells couple ER stress to mitochondrial apoptosis.

    abstract：:As myeloma cells actively produce and secrete immunoglobulins, they are prone to ER stress, which if unresolved leads to apoptosis. We found that myeloma cell death induced by the ER stressor Thapsigargin was highly variable, ranging from 2 to 89%. Induction of ATF4 and CHOP was observed in myeloma cells under Thapsig...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2016.09.030

    authors： Gomez-Bougie P,Halliez M,Moreau P,Pellat-Deceunynck C,Amiot M

    更新日期：2016-12-28 00:00:00

  • Inhibitory effects of triptogelin A-1 on 12-O-tetradecanoylphorbol-13- acetate-induced skin tumor promotion.

    abstract：:Dihydroagarofuran sesquiterpenes, which were isolated from Tripterygium wilfordii Hook fil. var. regelii Makino and Euonymus sieboldianus Blume, showed inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). Triptogelin A-1, one of the active di...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(93)90138-y

    authors： Ujita K,Takaishi Y,Tokuda H,Nishino H,Iwashima A,Fujita T

    更新日期：1993-02-01 00:00:00

  • Small molecule inhibitor agerafenib effectively suppresses neuroblastoma tumor growth in mouse models via inhibiting ERK MAPK signaling.

    abstract：:Neuroblastoma (NB) is the most common extracranial solid tumor in early childhood. Despite intensive multimodal therapy, nearly half of children with high-risk disease will relapse with therapy-resistant tumors. Dysregulation of MAPK pathway has been implicated in the pathogenesis of relapsed and refractory NB patient...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2019.05.011

    authors： Li H,Yu Y,Zhao Y,Wu D,Yu X,Lu J,Chen Z,Zhang H,Hu Y,Zhai Y,Su J,Aheman A,De Las Casas A,Jin J,Xu X,Shi Z,Woodfield SE,Vasudevan SA,Agarwal S,Yan Y,Yang J,Foster JH

    更新日期：2019-08-10 00:00:00

  • Absence of ras gene mutations in UV-induced malignant melanomas correlates with a dermal origin of melanocytes in Monodelphis domestica.

    abstract：:The South American opossum, Monodelphis domestica, has been used as a model system to study ultraviolet (UV)-induced genetic alterations that lead to the development of melanoma. Suckling young of Monodelphis exposed to multiple doses of UVB radiation can develop benign or malignant melanomas later as adults. Point mu...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(01)00783-2

    authors： Chan J,Robinson ES,Yeh IT,McCarrey JR

    更新日期：2002-10-08 00:00:00

  • Dysfunction of natural killer cells in patients with transitional cell carcinoma.

    abstract：:Previous studies had established that transforming growth factor-beta1 (TGF-beta1) is highly expressed in bladder tumor, facilitating progression and spreading of the cancerous cells. Here, we report that both the number and the cytotoxic function of natural killer (NK) cells are decreased in patients with superficial...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2009.09.019

    authors： Lin CT,Yu MT,Li C,Ho YC,Shen CH,Liu DW,Chang DC,Wu SF

    更新日期：2010-05-01 00:00:00