Abstract：
:NF-kappaB transcription factor regulates important cellular processes ranging from establishment of the immune and inflammatory responses to regulation of cell proliferation or apoptosis, through the induction of a large array of target genes. NF-kappaB is now considered as an important actor in the tumorigenic process mainly because it exerts strong anti-apoptotic functions in cancer cells. NF-kappaB is triggered by chimio- and radio-therapeutic strategies that are intended to eliminate cancerous cells through induction of apoptosis. Numerous studies have demonstrated that inhibition of NF-kappaB by different means increased sensitivity of cancer cells to the apoptotic action of diverses effectors such as TNFalpha or chemo- or radio-therapies. From these studies as emerged the concept that NF-kappaB blockade could be associated to conventional therapies in order to increase their efficiency. This review focuses on the current knowledge on NF-kappaB regulation and discusses the therapeutic potential of targeting NF-kappaB in cancer in particular during radiotherapy.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Magné N,Toillon RA,Bottero V,Didelot C,Houtte PV,Gérard JP,Peyron JFdoi
10.1016/j.canlet.2005.01.022keywords:
subject
Has Abstractpub_date
2006-01-18 00:00:00pages
158-68issue
2eissn
0304-3835issn
1872-7980pii
S0304-3835(05)00092-3journal_volume
231pub_type
杂志文章,评审相关文献
CANCER LETTERS文献大全abstract：:Residential radon exposure is considered the second cause of lung cancer and the first in never smokers. Nevertheless, the association between the different histological types of lung cancer and radon is not completely clear, and radon effect on small cell lung cancer is not completely understood. We aim to asses the ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2018.04.003
更新日期：2018-07-10 00:00:00
abstract：:Ibrutinib, an inhibitor of Bruton tyrosine kinase (BTK), has shown promising pharmacologic effects in acute myeloid leukemia (AML). In this study, we report that abivertinib or AC0010, a novel BTK inhibitor, inhibits cell proliferation, reduces colony-forming capacity, and induces apoptosis and cell cycle arrest in AM...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2019.07.008
更新日期：2019-10-01 00:00:00
abstract：:Boesenbergia pandurata (Zingiberaceae), Languas galanga (Zingiberaceae) and Citrus hystrix (Rutaceae) are edible plants that are commonly used as flavors or condiments in various Thai food dishes. They are known to exert strong anti-promoting activity in a test of tumor promoter-induced Epstein-Barr virus (EBV) activa...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(00)00530-9
更新日期：2000-10-01 00:00:00
abstract：:Piwi-interacting RNAs (piRNAs), new non-coding small RNAs, are association with chromatin organization, messenger RNA stability and genome structure. However, the roles of piRNA in carcinogenesis are not clearly defined. By using real-time reverse transcription-polymerase chain reaction technology, we found that the e...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2011.10.004
更新日期：2012-02-01 00:00:00
abstract：:We generated three anti-ErbB-2 monoclonal antibodies (mAbs) by using surface-epitope masking method (SEM method). They were characterized and shown to recognize the extracellular domain (ECD) of ErbB-2 specifically. In order to detect ErbB-2 in the sera of breast cancer patients, we used two of them: A18 and A21 to de...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(03)00017-x
更新日期：2003-04-25 00:00:00
abstract：:G protein-coupled oestrogen receptor 1 (GPER1), predicted to be a novel oestrogen receptor, has been linked to the development and progression of breast cancer. However, the molecular mechanisms underlying its functions remain elusive. Here, we show that the protein levels of GPER1 are negatively associated with those...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2020.10.019
更新日期：2021-02-01 00:00:00
abstract：:Lactoferrin, an iron-binding glycoprotein, exhibits suppressive effects on development of azoxymethane (AOM)-induced tumors in the rat colon, but the mechanisms are largely unknown. In this study, we investigated the effect of lactoferrin on the gene expression of 10 apoptosis-related molecules in colon mucosa of AOM-...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2004.03.029
更新日期：2004-09-15 00:00:00
abstract：:Both PTEN (encoding phosphate and tensin homologue) and p53 are known as cancer suppressor genes, and they are assumed that their gene mutations and loss of heterozygosity (LOH) occur frequently in various types of carcinoma. In the present study, we investigated both the p53 mutation and LOH of PTEN in 113 gastric ca...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2004.12.006
更新日期：2005-09-08 00:00:00
abstract：:Women who have breast cysts with intracystic Na+/K+ < 3 may have a higher risk of developing breast cancer than women who have breast cysts with intracystic Na+/K+ > 3. In this study wide-ranging intracystic concentrations of cathepsin D and pS2 (oestrogen inducible proteins/polypeptides) as well as oestradiol were fo...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(93)90027-7
更新日期：1993-04-15 00:00:00
abstract：:Hypusine formation on the eukaryotic initiation factor 5A (eIF-5A) precursor is ubiquitously present in eukaryotic cells and archebacteria. In this reaction, deoxyhypusine synthase catalyzes the conversion of one unique lysine residue on eIF-5A to deoxyhypusine using spermidine as the substrate. Hydroxylation of the d...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(97)04741-1
更新日期：1997-05-19 00:00:00
abstract：:Brain metastasis is an important cause of morbidity and mortality in cancer-patients. Breast tumor cells frequently metastasize to brain and initiate severe therapeutic complications. In the present study, we evaluated the anti-metastatic effects of 2'-hydroxyflavanone (2HF) alone and in combination with RLIP targeted...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2018.09.015
更新日期：2018-12-01 00:00:00
abstract：:The AT-rich interaction domain 1A (ARID1A, also known as BAF250a) is a chromatin remodeling gene, which frequently mutates across a broad spectrum of cancers with loss expression of the ARID1A protein. Recently, the association between ARID1A deficiency and immune checkpoint blockade (ICB) therapy has been reported. A...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2020.01.001
更新日期：2020-03-31 00:00:00
abstract：:The thiol N-acetylcysteine (NAC), a precursor of intracellular glutathione (GSH), efficiently prevented the induction of lung tumors in Swiss albino mice, when supplemented to the diet (0.2%) both before and after an i.p. injection of the carcinogen urethan (ethyl carbamate). Irrespective of urethan administration, NA...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(86)90175-8
更新日期：1986-09-01 00:00:00
abstract：:The mutational activation of the neu proto-oncogene was analyzed in schwannomas of the peripheral nervous system transplacentally induced by N-ethyl-N-nitrosourea (ENU) in rats. All nine primary schwannomas investigated contained a T-->A transversion mutation at nucleotide 2012 of the neu gene, leading to the substitu...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(93)90073-i
更新日期：1993-06-15 00:00:00
abstract：:Forty female CBA mice aged 3-4 months were exposed twice a week during 2 months to intravaginal applications of polyurethane sponges impregnated with 0.1% solution of 7,12-dimethylbenz[a]anthracene (DMBA) in triethyleneglycol. Three hours after each application the sponges were taken out. Starting from the day of the ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(00)00463-8
更新日期：2000-08-11 00:00:00
abstract：:Glioblastoma multiforme (GBM) is a brain tumor with a high mortality rate. Surgical resection combined with radiotherapy and chemotherapy is the standard treatment for GBM patients, but the 5-year survival rate of patients despite this treatment is low. Immunotherapy has attracted increasing attention in recent years....
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2020.09.028
更新日期：2021-01-01 00:00:00
abstract：:Glioblastoma (GBM) is the most aggressive, deadliest, and most common brain malignancy in adults. Despite the advances made in surgical techniques, radiotherapy and chemotherapy, the median survival for GBM patients has remained at a mere 14 months. GBM poses several unique challenges to currently available treatments...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2015.03.015
更新日期：2015-06-28 00:00:00
abstract：:EGFR polymorphisms have not been thoroughly evaluated for association with head and neck squamous cell carcinoma (HNSCC) risk. We genotyped 578 HNSCC patients and 588 cancer-free controls for 60 EGFR single nucleotide polymorphisms (SNPs) and tested associations with HNSCC risk. EGFR intronic SNPs rs12535536, rs207511...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2014.12.008
更新日期：2015-02-28 00:00:00
abstract：:The acquisition and persistence of fetal microchimerism, small numbers of genetically disparate cells from the fetus in the mother, is now a well-recognized consequence of normal pregnancy. Fetal microchimerism has been associated with several classical autoimmune diseases, but its role in normal health remains undefi...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2008.07.025
更新日期：2009-04-08 00:00:00
abstract：:The highly conserved RNA-binding protein, Lin28, is involved in many biological processes, including development, reprogramming, pluripotency, and metabolism. Importantly, Lin28 functions as an oncogene, promoting tumor progression and metastasis in various human cancers. Lin28 can regulate gene expression either by d...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2016.02.050
更新日期：2016-05-28 00:00:00
abstract：:The molecular chaperone Hsp90 is not only of major current interest in fundamental biological research but also recognised as an exciting new target for the treatment of cancer and other diseases. In addition to playing an important role in response to proteotoxic heat shock and others stresses, Hsp90 is also critical...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2003.08.032
更新日期：2004-04-08 00:00:00
abstract：:A hallmark of most cancer cells is an altered metabolism involving a shift to aerobic glycolysis with lactate production coupled with a higher uptake of glucose as the main source of energy. Lactate dehydrogenase 5 (LDH-5) catalyzes the reduction of pyruvate by NADH to form lactate, thus determining the availability o...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2014.12.035
更新日期：2015-03-01 00:00:00
abstract：:Pancreatic cancer is currently one of the deadliest solid malignancies and pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer. In the past decade, diagnostics and surgical techniques for PDAC have been evolving steadily; however, clinical outcomes of patients with PDAC have shown litt...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2015.01.023
更新日期：2015-04-10 00:00:00
abstract：:Frequent occurrence of chromosome 22q deletions in lung cancer indicates the presence of a tumor suppressor gene on this chromosome arm. The hSNF5/INI1 gene at chromosome 22q11.2 has recently been shown to act as a tumor suppressor in rhabdoid tumors. To investigate whether the hSNF5/INI1 gene located on chromosome 22...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(00)00342-6
更新日期：2000-05-29 00:00:00
abstract：:Two hepatoma cell lines were incubated for 72 h with ATRA and its analog 13cisRA and according to MTT assay, Hep3B cells were highly susceptible whereas HepG2 cells were more resistant to the treatment. At the high concentration of 166 microM, retinoids were able to induce apoptosis in both cell lines and the highest ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2005.06.047
更新日期：2005-11-18 00:00:00
abstract：:Administration of mannoheptulose partially protected mice infected with Listeria monocytogenes against the lethal effect of a subsequent endotoxin challenge. The ability of these animals to produce tumour necrosis factor was however unaffected. Mannoheptulose was observed to reverse the hypoglycaemic effect of endotox...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(87)90143-1
更新日期：1987-10-01 00:00:00
abstract：:Overall survival and quality of life of patients with metastatic colorectal cancer (mCRC) have improved due to the development of standard systemic treatment. However, many patients are still suffering from the eventual progression of cancer, treatment-related toxicities, and the economic burden of new drugs. Salvage ...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2017.02.034
更新日期：2017-08-01 00:00:00
abstract：:Cancer stem cells (CSC) are critical for initiation, metastasis, and relapse of cancers, however, the underlying mechanism governing stemness of CSC remains unknown. Herein, we have investigated the roles of phosphodiesterase 5 (PDE5) in stemness of prostate cancer cells. Both PDE5 and WW domain-containing transcripti...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2016.05.010
更新日期：2016-08-01 00:00:00
abstract：:Cell migration and invasion leading to metastasis is a major cause of death from endometrial cancer (EC). We have shown that the rate of EC cell migration is inversely related to the level of insulin-like growth factor protein-3 (IGFBP-3). Down-regulation of IGFBP-3 by siRNA in EC cells accelerated migration without a...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2011.11.011
更新日期：2012-04-01 00:00:00
abstract：:Monocrotaline is a representative naturally occurring genotoxic pyrrolizidine alkaloid. Metabolism of monocrotaline by liver microsomes of F344 female rats generated (+/-)6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine (DHP) and monocrotaline-N-oxide as major metabolites. Metabolism in the presence of triacetylea...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2004.11.039
更新日期：2005-08-08 00:00:00
