Pediatric human immunodeficiency virus infection and cancer in the highly active antiretroviral treatment (HAART) era.

abstract：:The present study was performed to investigate the possible role of mTOR inhibitors in restoring chemosensitivity to adriamycin/cisplatin and elucidate the underlying mechanism. Combining adriamycin/cisplatin with torisel synergistically inhibited the cell proliferation in human oropharyngeal carcinoma cell line KB an...

journal_title：Cancer letters

authors： Gaur S,Chen L,Yang L,Wu X,Un F,Yen Y

更新日期：2011-12-01 00:00:00

abstract：:Well-differentiated liposarcomas (WDLPS) and dedifferentiated liposarcomas are cytogenetically characterized by the presence of supernumerary ring or giant chromosomes containing amplified material from the 12q14-15 region. These chromosomes contain neocentromeres, which are able to bind the kinetochore proteins and t...

journal_title：Cancer letters

authors： Italiano A,Maire G,Sirvent N,Nuin PA,Keslair F,Foa C,Louis C,Aurias A,Pedeutour F

更新日期：2009-01-18 00:00:00

abstract：:Susceptibility of hairless inbred S/RV Cri-ba or Bare mice to skin tumor development with suboptimal doses of 7,12-dimethylbenz[a]anthracene (DMBA), DMBA-TPA two stage protocol and two stage promotion using 12-O-tetradecanoylphorbol-13-acetate (TPA) as sub-stage 1 promoter and mezerein (MEZ) or phorbol retinoate aceta...

journal_title：Cancer letters

authors： Bhisey RA,Veturkar PL

更新日期：1990-06-30 00:00:00

abstract：:The mixed lineage kinase domain-like protein (MLKL) has emerged as a critical mediator of necroptosis, which results in the release of cellular damage-associated molecular patterns (DAMPs). However, its physiological role in regulating inflammation is not fully understood. We herein showed that Mlkl-/- mice were highl...

journal_title：Cancer letters

authors： Zhao Q,Yu X,Li M,Liu Y,Han Y,Zhang X,Li XM,Wu X,Qin J,Fang J,Zhang H

更新日期：2019-09-10 00:00:00

abstract：:Cancer cachexia patients experience significant muscle wasting, which impairs the quality of life and treatment efficacy for patients. Skeletal muscle protein turnover is imparted by increased expression of ubiquitin-proteasome pathway components. Mitogen-activated protein kinases p38 and ERK have been shown to augmen...

journal_title：Cancer letters

authors： Mulder SE,Dasgupta A,King RJ,Abrego J,Attri KS,Murthy D,Shukla SK,Singh PK

更新日期：2020-10-28 00:00:00

abstract：:The number of Krebs II tumour cells recovered from the ascitic fluid of mice fed for 8 days on a lactalbumin (La) control diet was about three times higher than that in animals fed a phytohaemagglutinin-containing (PHA) diet. Feeding a PHA diet for less than 8 days after tumour cell injection also led to a reduction i...

journal_title：Cancer letters

authors： Bardocz S,Grant G,Duguid TJ,Brown DS,Pusztai A,Pryme IF

更新日期：1997-12-16 00:00:00

abstract：:Grp75 is a stress-inducible mitochondrial chaperone which has a high homology to senescence-related protein, p66mot mortalin. In human cells the mortalin gene assigns to the locus of a putative tumor suppressor gene for myeloid malignancies. In order to study expression and localization of Grp75 and p66mot in human an...

journal_title：Cancer letters

authors： Merrick BA,Walker VR,He C,Patterson RM,Selkirk JK

更新日期：1997-11-11 00:00:00

abstract：:We planned to determine the relationship between angiogenesis and p53 mutational status in advanced-stage epithelial ovarian cancer. Using 190 tumor samples from patients with stage III and IV ovarian cancer we performed p53 sequencing, immunohistochemistry, and CD31 microvessel density (MVD) determination. MVD was el...

journal_title：Cancer letters

authors： Nadkarni NJ,Geest KD,Neff T,Young BD,Bender DP,Ahmed A,Smith BJ,Button A,Goodheart MJ

更新日期：2013-04-30 00:00:00

abstract：:Acute myeloid leukemia (AML) cells in vivo are constantly exposed to lymphangiogenic cytokines such as VEGF-C. However, it is poorly understood how the VEGF-C signaling modulates the immune functions in the tumor microenvironment. We have previously reported that natural killer (NK) cells in AML patients strongly upre...

journal_title：Cancer letters

authors： Lee JY,Park S,Min WS,Kim HJ

更新日期：2014-11-28 00:00:00

abstract：:Interstitial fluid pressure was measured by the wick-in-needle technique in DMBA-induced rat mammary tumours during resting conditions and during noradrenaline infusion. The rate of infusion was chosen to increase the systemic blood pressure by 30-40 mmHg, known to result in a markedly increased vascular resistance of...

journal_title：Cancer letters

authors： Tveit E,Hultborn R,Weiss L

更新日期：1985-07-01 00:00:00

abstract：:The tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a lung carcinogen in the rat and believed to be a causative agent for lung cancer in smokers. To exert its carcinogenic potential NNK is metabolically activated by cytochrome P450-catalyzed alpha-hydroxylation. Nicotine and NNK s...

journal_title：Cancer letters

authors： Keyler D,Pentel PR,Kuehl G,Collins G,Murphy SE

更新日期：2003-12-08 00:00:00

abstract：:The effects of turmeric (T), curcumins (Cs), aqueous turmeric extract (ATE) and curcumin-free aqueous turmeric extract (CFATE) on the formation of [3H]benzo[a]pyrene ([3H]B(a)P)-derived DNA adducts was studied in vitro employing mouse liver S9. A dose-dependent decrease in binding of [3H]B(a)P metabolites to calf thym...

journal_title：Cancer letters

authors： Deshpande SS,Maru GB

更新日期：1995-09-04 00:00:00

abstract：:Therapeutic biomacromolecules are confronted with in vivo challenges of low bio-stability and poor tumor tissue-penetration. Herein, we report for the first time, our development and characterization of a hybrid nanocomposite for delivering a Bcl-2-converting peptide (NuBCP9, N9 hereafter) and testing its efficacy alo...

journal_title：Cancer letters

authors： Xie J,Xu W,Wu Y,Niu B,Zhang X

更新日期：2020-01-28 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is highly aggressive disease and current treatment regimens fail to effectively cure PDAC. Development of resistance to current therapy is one of the key reasons for this outcome. Nimbolide (NL), a triterpenoid obtained from Azadirachta indica, exhibits anticancer properties in ...

journal_title：Cancer letters

authors： Kumar S,Inigo JR,Kumar R,Chaudhary AK,O'Malley J,Balachandar S,Wang J,Attwood K,Yadav N,Hochwald S,Wang X,Chandra D

更新日期：2018-01-28 00:00:00

abstract：:Brain metastasis is an important cause of morbidity and mortality in cancer-patients. Breast tumor cells frequently metastasize to brain and initiate severe therapeutic complications. In the present study, we evaluated the anti-metastatic effects of 2'-hydroxyflavanone (2HF) alone and in combination with RLIP targeted...

journal_title：Cancer letters

authors： Singhal J,Singhal P,Horne D,Salgia R,Awasthi S,Singhal SS

更新日期：2018-12-01 00:00:00

abstract：:Overall survival and quality of life of patients with metastatic colorectal cancer (mCRC) have improved due to the development of standard systemic treatment. However, many patients are still suffering from the eventual progression of cancer, treatment-related toxicities, and the economic burden of new drugs. Salvage ...

journal_title：Cancer letters

authors： Woo IS,Jung YH

更新日期：2017-08-01 00:00:00

abstract：:Administration of mannoheptulose partially protected mice infected with Listeria monocytogenes against the lethal effect of a subsequent endotoxin challenge. The ability of these animals to produce tumour necrosis factor was however unaffected. Mannoheptulose was observed to reverse the hypoglycaemic effect of endotox...

journal_title：Cancer letters

authors： Choy YM,Cheng CP,Luey LU,Loh SC,Fung KP,Lee CY

更新日期：1987-10-01 00:00:00

abstract：:The effect of different tannin-containing aqueous solutions on the carcinogenic action of benzo(a)pyrene (BP) on the mouse skin was investigated. It was found that the appearance of tumours was accelerated in mice treated with either tea or an oak extract after a single application of BP. The time of appearance of tum...

journal_title：Cancer letters

authors： Bogovski P,Day N

更新日期：1977-07-01 00:00:00

abstract：:Previously, we showed that hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha, carbonic anhydrase IX (CA IX), and vascular endothelial growth factor (VEGF) were frequently coexpressed in tumor biopsies from patients of nasopharyngeal carcinoma (NPC) and were associated with poor outcome after radiotherapy. Here, we fur...

journal_title：Cancer letters

authors： Sung FL,Hui EP,Tao Q,Li H,Tsui NB,Lo YM,Ma BB,To KF,Harris AL,Chan AT

更新日期：2007-08-08 00:00:00

abstract：:Chromosomal assignment of human transcribed sequences has been done mainly by high throughput genome analysis in specialized genome centres and, in a more classical fashion, by fluorescence in-situ hybridization (FISH) analysis. Not every laboratory has the ability to map cDNAs by FISH analysis. We here report a rapid...

journal_title：Cancer letters

authors： Claas A,Savelyeva L,Pillmann A,Schwab M

更新日期：2001-01-10 00:00:00

abstract：:Survivin is a recently characterised inhibitor of apoptosis protein that has been implicated in the pathogenesis of several types of solid organ cancer. This study sought to describe the expression of survivin in a cohort of 90 benign meningiomas, together with the pattern of expression of other genes involved in the ...

journal_title：Cancer letters

authors： Das A,Tan WL,Smith DR

更新日期：2003-04-25 00:00:00

abstract：:Pancreatic cancer is one of the most devastating diseases with very poor prognosis. Only a small proportion is curable by surgical resection, whilst standard chemotherapy for patients with advanced disease has only modest effect with substantial toxicity. Therefore, there is an urgent need for the development of novel...

journal_title：Cancer letters

authors： Xu C,Li H,Su C,Li Z

更新日期：2013-06-01 00:00:00

abstract：:Amplification and overexpression of PPM1D (protein phosphatase magnesium-dependent 1 delta) has been observed in various cancer cell lines and primary tumors and has also been associated with cancers of poor prognosis. In addition to the negative feedback regulation of p38-p53 signaling, PPM1D inhibits other tumor sup...

journal_title：Cancer letters

authors： Pärssinen J,Alarmo EL,Khan S,Karhu R,Vihinen M,Kallioniemi A

更新日期：2008-01-18 00:00:00

abstract：:New, potentially tumor-specific antigens have been described in Bcr/Abl positive leukemias. Besides the main BCR/ABL hybrid fusion transcripts, a small number of transcripts derived from alternative splicing between BCR exons 1, 13, and 14 with ABL exons 4 and 5 have been identified. These variants are expressed in ch...

journal_title：Cancer letters

authors： Casnici C,Volpe G,Lattuada D,Crotta K,Kuka M,Panuzzo C,Mastrotto C,Tonon G,Fazio VM,Saglio G,Marelli O

更新日期：2009-04-08 00:00:00

abstract：:Multidrug resistance (MDR) is a serious obstacle for cancer chemotherapy. The aim of this study was to reverse MDR of breast carcinoma cells specifically by degrading mdr1 mRNA with anti-mdr1 ribozyme. Our strategy was to limit the expression of ribozyme to only breast-derived cells, but not other type of cells. The r...

journal_title：Cancer letters

authors： Gao P,Zhou GY,Guo LL,Zhang QH,Zhen JH,Fang AJ,Lin XY

更新日期：2007-10-18 00:00:00

abstract：:Application of a single high dose of 7,12-dimethylbenz[a]anthracene (DMBA, 1 mg) or N-nitrosomethylurea (NMU, 0.4 mg) to the ears of either athymic nu/nu or phenotypically normal nu/+ mice (BALB/c background) resulted in the appearance of cutaneous sebaceous adenomas as well as squamous cell tumors, both at the site o...

journal_title：Cancer letters

authors： Rice JM,Anderson LM

更新日期：1986-12-01 00:00:00

abstract：PURPOSE:The purpose of this study is to examine the changes in the number of HSF1 granules in the nucleus caused by different degree of heat stress. MATERIALS AND METHODS:A human esophageal cancer cell line, TE-2, was used. HSF1 granules were examined in an immunofluorescence study, and the changes in the average numb...

journal_title：Cancer letters

authors： Nonaka T,Akimoto T,Mitsuhashi N,Tamaki Y,Nakano T

更新日期：2003-12-08 00:00:00

abstract：:Cancerous breast hyperthermia is seemingly associated with non-neurological vasodilation modulated by nitric oxide (NO). NO, associated with enhanced immune response, is produced autocatalytically involving ferritin as the supplier of Fe2+, which catalyses the formation of NO. NO, in turn, releases Fe2+ from ferritin....

journal_title：Cancer letters

authors： Anbar M

更新日期：1994-08-29 00:00:00

abstract：INTRODUCTION/HYPOTHESIS:Over-expression of the c-Met receptor tyrosine kinase has been described in a variety of cancers and implicated in tumor progression. Unlike some solid tumors, current evidence indicates that c-Met activation in colon cancer is unrelated to gene mutation, is ligand dependent, and occurs via a pa...

journal_title：Cancer letters

authors： Kammula US,Kuntz EJ,Francone TD,Zeng Z,Shia J,Landmann RG,Paty PB,Weiser MR

更新日期：2007-04-18 00:00:00

abstract：:Multiple cancers contain subpopulations that exhibit characteristics of cancer stem cells (CSCs), the ability to self-renew and seed heterogeneous tumors. Recent evidence suggests two potentially overlapping models for these phenotypes: one where stem cells arise from multipotent progenitor cells, and another where th...

journal_title：Cancer letters

authors： Chang JT,Mani SA

更新日期：2013-11-28 00:00:00