Inhibition of NMU-induced mammary tumorigenesis by dietary soy.

Abstract:

:We previously demonstrated that female Sprague-Dawley rats fed AIN-93G diets containing soy protein isolate (SPI+) had lower DMBA-induced mammary tumor incidence than those fed diets containing casein (CAS), due partly to altered Phase I metabolism with soy. Here, we evaluated the tumor protective effects of these same diets to the direct-acting carcinogen N-methyl-nitrosourea (NMU). Tumor incidence was reduced and tumor latency was enhanced, in NMU-administered female rats lifetime exposed to SPI+, relative to the CAS group. Tumor multiplicity did not differ with diet, while tumor grade tended to be more advanced with SPI+. Normal mammary glands of CAS and SPI+ tumor-bearing rats had comparable proliferative and apoptotic status. However, mammary expression of HER-2/neu and progesterone receptor (PR) genes was higher for SPI+ rats. Moreover, tumored SPI+ rats had lower serum progesterone levels than those fed CAS, while serum estrogen did not differ. Serum from tumored SPI+ rats had higher apoptotic activity towards mammary epithelial MCF-7 cells, than CAS serum. Thus, dietary soy protects against mammary tumorigenesis induced by a direct-acting carcinogen and alters signaling pathways involving PR and HER-2/neu.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Simmen RC,Eason RR,Till SR,Chatman L Jr,Velarde MC,Geng Y,Korourian S,Badger TM

doi

10.1016/j.canlet.2004.11.009

keywords:

subject

Has Abstract

pub_date

2005-06-16 00:00:00

pages

45-52

issue

1

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(04)00859-6

journal_volume

224

pub_type

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