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Exosomes: Emerging biomarkers and targets for ovarian cancer.

Abstract：

:The limitations of current chemotherapies have motivated research in developing new treatments. Growing evidence shows that interaction between tumors and their microenvironment, but not tumor cells per se, is the key factor in tumor progression and therefore of obvious scientific interest and therapeutic value. Exosomes are small (30-100 nm) extracellular vesicles which have emerged as key mediators of intercellular communication between tumor cells and major cell types in the tumor microenvironment such as fibroblasts, endothelial cells, and immune cells as well as noncellular extracellular matrices through paracrine mechanisms. This review is to highlight the emerging role of exosomes in particular types of cancer, such as ovarian cancer, owing to its unique route of metastasis, which is capable of rapidly translating exosome research for clinical applications in diagnosis, prognosis, and potential treatment.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Tang MK,Wong AS

doi

10.1016/j.canlet.2015.07.014

subject

Has Abstract

pub_date

2015-10-10 00:00:00

pages

26-33

issue

1

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(15)00456-5

journal_volume

367

pub_type

杂志文章,评审

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