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DNA adducts in tissues of germ-free and conventional rats fed high- and low-esterified pectins.

Abstract：

:Tissue samples from germ-free and conventional rats fed pectins with different degrees of esterification (DE) were tested for containing indigenous DNA adducts (I-compounds). For 21 days groups of six germ-free and 10 conventional rats each were fed either pectin-free or with diets containing 7.5% of three differently esterified pectin preparations (Pectin A, DE 92.6%; Pectin B, DE 70.8%; Pectin C, DE 34.5%). DNA was isolated from colonic mucosa, liver, lung, kidney and analysed for DNA adducts by the 32P-postlabelling assay. The experiments showed a tendency to a higher number and intensity of DNA-adduct-like spots (1) in the colonic mucosa compared with liver, lung, and kidney, (2) in germ-free compared with conventional rats, (3) with pectin-free compared with pectin-containing diets, (4) under the low-esterified compared with the higher-esterified pectins.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Zunft HJ,Goldin-Lang P,Dongowski G

doi

10.1016/s0304-3835(97)04621-1

subject

Has Abstract

pub_date

1997-03-19 00:00:00

pages

43-6

issue

1-2

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(97)04621-1

journal_volume

114

pub_type

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