Inhibition by zinc of hepatic lysosomal release of beta-glucuronidase induced by phorbol-12-myristate-13-acetate (PMA).

Abstract:

:The tumor promoter, phorbol-12-myristate-13-acetate (PMA), elicited a significant increase in lysosomal membrane permeability, as measured by release of free beta-glucurnidase, in guinea pig and hamster isolated hepatic lysosomes in vitro. This response was antagonized by zinc sulfate; zinc compounds having previously been shown to inhibit tumor growth at multiple sites in several species. Since phorbol ester tumor promotion is likely associated in part with actions on cellular membrane systems, its inhibition by zinc may relate to the membrane stabilizing activity of zinc compounds.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Pfeiffer CJ,Cho CH

doi

10.1016/0304-3835(80)90065-8

subject

Has Abstract

pub_date

1980-07-01 00:00:00

pages

51-6

issue

1

eissn

0304-3835

issn

1872-7980

pii

0304-3835(80)90065-8

journal_volume

10

pub_type

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