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Histone deacetylase inhibition induces apoptosis and autophagy in human neuroblastoma cells.

Abstract：

:Neuroblastoma (NB) is the most common solid extracranial tumor in children. Here we showed that trichostatin A, a histone deacetylase inhibitor (HDACi), decreases cell viability in three NB cell lines of different phenotypes. The treatment leads to G2/M-phase arrest, apoptosis and autophagy. Autophagy induction accompanies apoptosis in the most proliferative, N-Myc overexpressing cells. In contrast, autophagy precedes apoptosis and acts as a protective mechanism in the less proliferative, non-N-Myc overexpressing cells. Therefore, the autophagy induction is a relevant event in the NB response to HDACis, and it should be considered in the design of new treatments for this malignancy.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Francisco R,Pérez-Perarnau A,Cortés C,Gil J,Tauler A,Ambrosio S

doi

10.1016/j.canlet.2011.11.036

subject

Has Abstract

pub_date

2012-05-01 00:00:00

pages

42-52

issue

1

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(11)00738-5

journal_volume

318

pub_type

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