Abstract:
:The susceptibility of analbuminemic rats, a mutant strain of Sprague-Dawley rats, to bladder carcinogens was examined by testing the agglutinability of isolated bladder epithelial cells by Concanavalin A (Con A). One-week treatment with 0.001% N-butyl-N-(4-hydroxybutyl)nitrosamine (BHBN) in the drinking water or 0.01% N-(4-(5-nitro-2-furyl)-2-thiazolyl)-formamide (FANFT), 0.01% and 0.1% 4-aminobiphenyl, 0.1% 4-nitrobiphenyl, 0.1% benzidine, 0.1% 2-napthylamine or 5% sodium saccharin in the diet clearly induced high agglutinability of bladder cells of male analbuminemic rats but not Sprague-Dawley rats. These results suggest that male analbuminemic rats are very susceptible to bladder carcinogens in general and therefore will be very useful in screening tests for bladder carcinogens.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Honma Y,Kakizoe T,Komatsu H,Niijima T,Sugimura T,Nagase Sdoi
10.1016/0304-3835(83)90128-3subject
Has Abstractpub_date
1983-05-01 00:00:00pages
7-11issue
1eissn
0304-3835issn
1872-7980pii
0304-3835(83)90128-3journal_volume
19pub_type
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