Abstract：
:The effect of the peptide hormone insulin upon the differentiation of a 10T1/2-derived preadipocytic line was found to display a potent time-dependence. Insulin addition before cell confluence strongly enhanced differentiation, while addition after confluence had no effect. In keeping with the role of c-Ras as a downstream effector of insulin, c-ras downregulation before confluence abolished differentiation, while it was ineffective once the process of differentiation was underway. These data suggest that the insulin signal is effective during an early window of time before cell confluence, while normal c-Ras levels are required for its transmission.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Preston T,Brownell H,Raptis Ldoi
10.1016/s0304-3835(97)04724-1subject
Has Abstractpub_date
1997-05-19 00:00:00pages
165-71issue
2eissn
0304-3835issn
1872-7980pii
S0304-3835(97)04724-1journal_volume
115pub_type
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