Follow-up of metastatic breast cancer patients with a mucin-like carcinoma-associated antigen: comparison to CA 15.3 and carcinoembryonic antigen.

abstract：:Transduction of the human interleukin-2 (IL-2) gene into tumor cells was carried out in order to develop a new immunotherapy for advanced head and neck carcinomas with a poor outcome. We transduced the IL-2 gene into KB cells, a head and neck squamous cell carcinoma cell line, using a defective herpes simplex viral (H...

journal_title：Cancer letters

authors： Mizuno H,Yanoma S,Nishimura G,Hattori S,Ito T,Okudera K,Tsukuda M

更新日期：2000-05-01 00:00:00

abstract：:Trastuzumab (or Herceptin), as the first erbB2-targeted therapy, has been successfully used to treat breast cancer patients with erbB2-overexpressing tumors. However, resistances to trastuzumab frequently occur, and novel strategies/agents are urgently needed to abrogate the resistant phenotype. Our current study expl...

journal_title：Cancer letters

authors： Huang X,Wang S,Lee CK,Yang X,Liu B

更新日期：2011-08-01 00:00:00

abstract：:We present here a new cell line, NOR-P1, established from a metastatic subcutaneous tumor of a patient with pancreatic cancer. The cells show rapid growth in culture with a doubling time of 16 h and high migration activity. Genetic and molecular analyses revealed high telomerase activity and a mutation in the K-ras on...

journal_title：Cancer letters

authors： Sato N,Mizumoto K,Beppu K,Maehara N,Kusumoto M,Nabae T,Morisaki T,Katano M,Tanaka M

更新日期：2000-07-31 00:00:00

abstract：:Cancer stem cells, also known as tumor-initiating cells (TICs), are a population of aggressive and self-renewing cells that are responsible for the initiation and progression of many cancers, including colorectal carcinoma. Intratumoral hypoxia, i.e. reduced oxygen supply following uncontrolled proliferation of cancer...

journal_title：Cancer letters

authors： Ullmann P,Nurmik M,Schmitz M,Rodriguez F,Weiler J,Qureshi-Baig K,Felten P,Nazarov PV,Nicot N,Zuegel N,Haan S,Letellier E

更新日期：2019-05-28 00:00:00

abstract：:Four glycoglycerolipid analogues, 1-O-hexanoyl-2-O-beta-D-glucopyranosyl-sn-glycerol (1), 1-O-hexanoyl-2-O-beta-D-galactopyranosyl-sn-glycerol (2), 2-O-(6-O-hexanoyl-beta-D-galactopyranosyl)-sn-glycerol (3) and 2-O-(6-O-hexanoyl-alpha-D-galactopyranosyl)-sn-glycerol (4), potent in vitro inhibitors of 12-O-tetradecanoy...

journal_title：Cancer letters

authors： Colombo D,Compostella F,Ronchetti F,Scala A,Toma L,Kuchide M,Tokuda H,Nishino H

更新日期：2000-12-20 00:00:00

abstract：:Epstein-Barr virus (EBV) has been well documented in the aetiology of nasopharyngeal carcinoma (NPC), although its role as well as the genetic basis in the genesis of NPC have not been elucidated. The p53 gene mutations are infrequently found in NPC, but the expression of p53 protein, as well as bcl-2 oncoprotein, has...

journal_title：Cancer letters

authors： Niemhom S,Kitazawa S,Murao S,Kunachak S,Maeda S

更新日期：2000-11-28 00:00:00

abstract：:Though many investigators have reported relationships between the CCND1 polymorphism and susceptibility to various carcinomas, to our knowledge, no report has been issued concerning its relationship with uterine cervical cancer. Thus, we undertook this study to investigate the association between CCND1 polymorphisms a...

journal_title：Cancer letters

authors： Jeon YT,Kim JW,Song JH,Park NH,Song YS,Kang SB,Lee HP

更新日期：2005-06-08 00:00:00

abstract：:Resistance to anoikis is a hallmark of human malignancies. Our results showed that hepatoma cells resisted anoikis by non-proliferation, non-apoptosis and cell cycle arrest which were termed synoikis-like. These synoikis-like cells are more resistant to extracellular stimuli and could spontaneously attach and prolifer...

journal_title：Cancer letters

authors： Zhang Z,Cao L,Li J,Liang X,Liu Y,Liu H,Du J,Qu Z,Cui M,Liu S,Gao L,Ma C,Zhang L,Han L,Sun W

更新日期：2008-08-18 00:00:00

abstract：:Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric transcription factor composed of alpha and beta subunits, which plays an essential role in cancer cell hypoxia adaptation, glycolysis, and angiogenesis. Normally, HIF-1alpha protein, the dominant subunit of HIF-1, is accumulated in nuclei when cells are exposed to ...

journal_title：Cancer letters

authors： Zhong H,Mabjeesh N,Willard M,Simons J

更新日期：2002-07-26 00:00:00

abstract：:Neoxanthin and fucoxanthin, which have the characteristic structure of 5,6-monoepoxide and an allenic bond, were previously found to reduce the viability of human prostate cancer cells most intensively among 15 dietary carotenoids tested. In the present study, the induction of apoptosis in PC-3 cells by these two caro...

journal_title：Cancer letters

authors： Kotake-Nara E,Asai A,Nagao A

更新日期：2005-03-18 00:00:00

abstract：:In this study, we investigated the antitumor effects of deguelin in several human breast cancer cells in vitro and in vivo. Deguelin inhibited cell viability and the anchorage-dependent and anchorage-independent colony formation of triple-negative (MDA-MB-231 and MDA-MB-468) and triple-positive (MCF-7) breast cancer c...

journal_title：Cancer letters

authors： Suh YA,Kim JH,Sung MA,Boo HJ,Yun HJ,Lee SH,Lee HJ,Min HY,Suh YG,Kim KW,Lee HY

更新日期：2013-05-10 00:00:00

abstract：:Many studies have shown that the activation of beta-catenin signaling can promote oncogenesis, and it is therefore of interest to find agents that modulate this pathway. Recent work has shown using B lymphoma cells that infection by Epstein-Barr virus (EBV) and expression of its latent membrane protein (LMP)-1, cause ...

journal_title：Cancer letters

authors： Min HJ,Cho IR,Srisuttee R,Park EH,Cho DH,Ahn JH,Lee IS,Johnston RN,Oh S,Chung YH

更新日期：2009-04-18 00:00:00

abstract：:The plant species Ephedra is commonly used in both folk medicine and for the preparation of health teas. Nitrosation of a tea made from Ephedra altissima yielded N-nitrosoephedrine (NEP), N-nitrosopseudoephedrine (NPEP), N-nitrosoproline (NPRO), N-nitrosomethylbenzylamine (NMBA), trace quantities of 2 unidentified non...

journal_title：Cancer letters

authors： Tricker AR,Wacker CD,Preussmann R

更新日期：1987-05-01 00:00:00

abstract：:In a development trial for an initiation bioassay system, cell proliferation kinetics after partial hepatectomy (PH) or CCl4 administration (1 ml/kg b.w., i.g.) and the effect of administration time after PH or CCl4 treatment on liver cell foci induction by the direct and indirect non-hepatocarcinogens, N-methyl-N'-ni...

journal_title：Cancer letters

authors： Kobayashi K,Mutai M,Goto K,Inada K,Tsukamoto T,Nakanishi H,Tatematsu M

更新日期：1997-09-16 00:00:00

abstract：:We measured colonic effluent samples from 10 patients with colorectal cancer, 13 with adenomatous polyps, 14 with normal colons and compared them to 10 patients with inflammatory bowel disease by measuring this CA19-9 content. Results showed considerable overlap between the different pathologic categories, making diff...

journal_title：Cancer letters

authors： Tobi M,Steinberg W,Henry J,Nochomovitz L

更新日期：1991-10-01 00:00:00

abstract：:Since angiogenesis is considered essential for tumor growth and the development of metastasis, we assessed the correlation of microvessel density (MVD) with overall survival in patients with epithelial ovarian cancer. Histologic slides were immunostained for CD34-antigen. MVD was determined within each tumor by enumer...

journal_title：Cancer letters

authors： Obermair A,Wasicky R,Kaider A,Preyer O,Lösch A,Leodolter S,Kölbl H

更新日期：1999-04-26 00:00:00

abstract：:The thiol N-acetylcysteine (NAC), a precursor of intracellular glutathione (GSH), efficiently prevented the induction of lung tumors in Swiss albino mice, when supplemented to the diet (0.2%) both before and after an i.p. injection of the carcinogen urethan (ethyl carbamate). Irrespective of urethan administration, NA...

journal_title：Cancer letters

authors： De Flora S,Astengo M,Serra D,Bennicelli C

更新日期：1986-09-01 00:00:00

abstract：:In this study we combined flow cytometry with fluorescence in situ hybridization to detect numerical aberrations in chromosomes. Fifty-nine human malignant gliomas were examined by flow cytometry for DNA-content and cell cycle analysis and for numerical aberrations of chromosome 1 by in situ hybridization using a chro...

journal_title：Cancer letters

authors： Ehemann V,Hashemi B,Lange A,Otto HF

更新日期：1999-04-26 00:00:00

abstract：:To shed light on the association of intestinal microflora with the development of colon cancer, we studied the modifying effects of intestinal microflora on the occurrence of 1,2-dimethylhydrazine (DMH)-induced colonic aberrant crypt foci (ACF) in germfree (GF), gnotobiotic (GB) and conventionalized (Cvd) rats. In the...

journal_title：Cancer letters

authors： Onoue M,Kado S,Sakaitani Y,Uchida K,Morotomi M

更新日期：1997-02-26 00:00:00

abstract：:The activity of cancer procoagulant (CP), prothrombin time (PT), activated partial thromboplastin time (APTT), the concentration of thrombin-antithrombin complexes (TAT) and the concentration of fibrinogen were analysed in blood of breast cancer patients scheduled for surgery. The serum level of CP activity was depend...

journal_title：Cancer letters

authors： Mielicki WP,Tenderenda M,Rutkowski P,Chojnowski K

更新日期：1999-11-01 00:00:00

abstract：AIM:the ability of the breast cancer-associated placental acid isoform of ferritin (p43-PLF) to modulate cell surface expression of HLA, CD59 (protectin) and CD66 antigen (adhesion antigen related to CEA) was examined. METHODS:the expression of these antigens in human breast carcinoma cell lines BT-20, T47D and MDA-MB...

journal_title：Cancer letters

authors： Sedlak J,Reinerova M,Hunakova L,Ausch C,Chorvath B,Rosen H,Moroz C

更新日期：1995-07-20 00:00:00

abstract：:Highly invasive and rapidly fatal, small-cell lung cancer (SCLC) has been an insurmountable gulf since discovery. Innate immunity plays a vital role in anti-tumor response, among which macrophages contribute to an indispensable character. Here, we found that macrophage infiltration in SCLC reduced significantly in a s...

journal_title：Cancer letters

authors： Zheng Y,Wang Z,Wei S,Liu Z,Chen G

更新日期：2021-02-28 00:00:00

abstract：:Aberrant activation of signal transducer and activator of transcription 3 (STAT3) is frequently observed in multiple myeloma (MM) cancer and can upregulate the expression of several genes involved in proliferation, survival, metastasis, and angiogenesis. The effect of farnesol (FOH) on STAT3 activation, associated pro...

journal_title：Cancer letters

authors： Lee JH,Kim C,Kim SH,Sethi G,Ahn KS

更新日期：2015-05-01 00:00:00

abstract：:Growing epidemiological evidence points out the carcinogenic hazard of inhaled aflatoxin B1 (AFB1) to the pulmonary system. Metabolism of AFB1 by lung microsomes and its binding to calf thymus DNA are reported for the first time in this paper. In addition, the ability of dietary butylated hydroxyanisole (BHA) to modul...

journal_title：Cancer letters

authors： Allameh A,Saxena M,Raj HG

更新日期：1988-05-01 00:00:00

abstract：:Circular RNAs (circRNAs) are a class of non-coding RNAs that do not have 5' end caps or 3' end poly (A) tails. There are more than one hundred thousand genes that encode circRNAs. Clinical data show that there are differences in the expression of circRNAs in a variety of diseases, including cancer, suggesting that cir...

journal_title：Cancer letters

authors： Zhou R,Wu Y,Wang W,Su W,Liu Y,Wang Y,Fan C,Li X,Li G,Li Y,Xiong W,Zeng Z

更新日期：2018-07-01 00:00:00

abstract：:Glioblastoma (GBM) is the most common and aggressive primary brain tumor. Great interest persists in useful therapeutic targets in GBM. Aberrant expression of long non-coding RNAs (lncRNAs) has been functionally associated with many cancers. Here, we elucidated the function and the possible molecular mechanisms of lnc...

journal_title：Cancer letters

authors： Yao Y,Ma J,Xue Y,Wang P,Li Z,Liu J,Chen L,Xi Z,Teng H,Wang Z,Li Z,Liu Y

更新日期：2015-04-01 00:00:00

abstract：:The relative sensitivities of different tumor cells to photodynamic therapy (PDT) with benzoporphyrin derivative monoacid ring A (BPD-MA) were compared in the four tumor cells. A good correlation was observed between the cell survival at 0.1 microg/ml of BPD-MA and sensitizer uptake/10(6) cells (r = -0.99) or the plat...

journal_title：Cancer letters

authors： Osaki T,Takagi S,Hoshino Y,Okumura M,Fujinaga T

更新日期：2006-11-18 00:00:00

abstract：:To date, several kinds of immunomodulating monoclonal antibodies (mAbs) have been applied in clinical trials, such as anti-cytotoxic T-lymphocyte antigen-4 (anti-CTLA-4) mAb and anti-programmed death-1 (anti-PD-1) mAb. With the recent success of cancer immunotherapy, especially the checkpoint inhibitors, the renewed i...

journal_title：Cancer letters

authors： Teng F,Kong L,Meng X,Yang J,Yu J

更新日期：2015-08-28 00:00:00

abstract：:Parthanatos is a new form of programmed cell death that is regulated by hyper-activated PARP-1, and is emerging as a new strategy to kill cancer cells. Deoxypodophyllotoxin (DPT) is a natural chemical that is found to induce cancer cell death, in which the role of parthanatos is unknown. Thus, we investigated this iss...

journal_title：Cancer letters

authors： Ma D,Lu B,Feng C,Wang C,Wang Y,Luo T,Feng J,Jia H,Chi G,Luo Y,Ge P

更新日期：2016-02-28 00:00:00

abstract：:Cancer stem cells (CSCs) represent a minor population that have clonal tumor initiation and self-renewal capacity and are responsible for tumor initiation, metastasis, and therapeutic resistance. CSCs reside in niches, which are composed of diverse types of stromal cells and extracellular matrix components. These stro...

journal_title：Cancer letters

authors： Saijo A,Goto H,Nakano M,Mitsuhashi A,Aono Y,Hanibuchi M,Ogawa H,Uehara H,Kondo K,Nishioka Y

更新日期：2018-05-01 00:00:00