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4-Methyl-3-nitro-benzoic acid, a migration inhibitor, prevents breast cancer metastasis in SCID mice.

Abstract：

:Metastasis remains a formidable problem in malignant tumors. In this study, MTT assay revealed that 4-methyl-3-nitro-benzoic acid (MNBA) had no effect on cell viability and did not interfere with cell cycle in any breast cancer cell lines tested. However, treatment with MNBA on breast cancer cells can inhibit EGF-induced migration and chemotaxis in vitro. In vivo assay demonstrated that MNBA and Paclitaxel synergistically inhibited tumor growth and metastasis in breast cancer SCID mice xenografts. These results suggest that MNBA is a potent inhibitor cancer cell chemotaxis and may be developed into a novel anti-metastasis drug.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Guo H,Li M,Chen P,Blake DJ,Kong X,Hao X,Niu R,Zhang N

doi

10.1016/j.canlet.2011.02.028

subject

Has Abstract

pub_date

2011-06-01 00:00:00

pages

69-75

issue

1

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(11)00121-2

journal_volume

305

pub_type

杂志文章

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