Abstract:
:Cytological appearance of fragile sites as non-staining gaps in metaphase chromosomes suggests an abnormality in chromatin structure. Studies of fragile sites at three levels of chromosome organization: (1) examining the ability of DNA derived from fragile sites to form nucleosomes-the basic structural element of chromosomes, (2) probing the arrangement of nucleosome arrays over fragile sites in fragile site-expressing cell lines, and (3) visualizing fragile sites in higher-order chromatin organization, reveal an unusual chromatin structure associated with fragile sites. This fragile site-associated chromatin structure might play an active role in DNA metabolic processes such as replication, transcription, repair and recombination, which are closely linked to the instability of fragile sites.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Wang YHdoi
10.1016/j.canlet.2005.07.040keywords:
subject
Has Abstractpub_date
2006-01-28 00:00:00pages
70-8issue
1eissn
0304-3835issn
1872-7980pii
S0304-3835(05)00828-1journal_volume
232pub_type
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