Abstract：
:Matrilysin and gelatinase A, B mRNA expressions were examined in colorectal tumors. Matrilysin mRNA was observed exclusively in tumors, while the others were also found in normal mucosa surrounding tumors. Further analysis revealed that colorectal adenomas with severe dysplasia, not with mild dysplasia, expressed matrilysin with lower levels than cancers. The level of matrilysin mRNA expression increased with the advancement of stages of colorectal cancers, consequently a relatively higher expression was observed in liver metastatic tumors than primary tumors. These results suggest that matrilysin mRNA expression was correlated with the progression of colorectal tumors, and this enzyme may also play a role in developing metastatic tumors in liver.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Ishikawa T,Ichikawa Y,Mitsuhashi M,Momiyama N,Chishima T,Tanaka K,Yamaoka H,Miyazakic K,Nagashima Y,Akitaya T,Shimada Hdoi
10.1016/0304-3835(96)04336-4subject
Has Abstractpub_date
1996-10-01 00:00:00pages
5-10issue
1eissn
0304-3835issn
1872-7980pii
0304383596043364journal_volume
107pub_type
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