Enhancing effect of oxymetholone, an anabolic steroid, on development of liver cell foci in rats initiated with N-diethylnitrosamine.

abstract：:Helicobacter pylori infection is the most important risk factor in the development of non-cardia gastric adenocarcinoma; host genetic variability and dietary co-factors also modulate risk. Because most H. pylori infections do not cause cancer, H. pylori heterogeneity has been investigated to identify possible virulenc...

journal_title：Cancer letters

authors： Wen S,Moss SF

更新日期：2009-09-08 00:00:00

abstract：:To date, several kinds of immunomodulating monoclonal antibodies (mAbs) have been applied in clinical trials, such as anti-cytotoxic T-lymphocyte antigen-4 (anti-CTLA-4) mAb and anti-programmed death-1 (anti-PD-1) mAb. With the recent success of cancer immunotherapy, especially the checkpoint inhibitors, the renewed i...

journal_title：Cancer letters

authors： Teng F,Kong L,Meng X,Yang J,Yu J

更新日期：2015-08-28 00:00:00

abstract：:We have previously shown that oligonucleotides designed to bind in triplex fashion to a specific p53 binding site homology inhibit the proliferation of colon cancer cells in vitro. The present study was designed to extend these observations in an in vivo model. HCT 116 human colon carcinoma cells were injected subcuta...

journal_title：Cancer letters

authors： Re RN,Cook JL,Giardina JF

更新日期：2004-06-08 00:00:00

abstract：:Exposure of HeLa cells to 0, 5, 10, 25, 50 and 100 microg/ml of guduchi extracts (methanol, aqueous and methylene chloride) resulted in a dose-dependent but significant increase in cell killing, when compared to non-drug-treated controls. The effects of methanol and aqueous extracts were almost identical. However, met...

journal_title：Cancer letters

authors： Jagetia GC,Nayak V,Vidyasagar MS

更新日期：1998-05-15 00:00:00

abstract：:We assessed whether current therapies could lead to hematogenous dissemination of malignant hepatocytes in hepatocellular carcinoma (HCC) patients using semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR) for alpha-fetoprotein (afp) and albumin (alb) mRNAs. We analyzed 137 peripheral blood sampl...

journal_title：Cancer letters

authors： Wong IH,Yeo W,Leung T,Lau WY,Johnson PJ

更新日期：2001-06-26 00:00:00

abstract：:Cancer-associated fibroblasts (CAFs) remain active even in the absence of cancer cells. However, the molecular mechanism underlying the sustained active status of CAFs is largely unrevealed. We found that in CAFs, DNMT3B was not only a target of miR-200b, miR-200c and miR-221, but was able to induce DNA methylation of...

journal_title：Cancer letters

authors： Tang X,Tu G,Yang G,Wang X,Kang L,Yang L,Zeng H,Wan X,Qiao Y,Cui X,Liu M,Hou Y

更新日期：2019-06-28 00:00:00

abstract：:Relative frequencies of diethylnitrosamine (DEN)-initiated foci of altered hepatocytes appearing in response to promotion by either dietary phenobarbital or a topically applied coal-derived organic mixture (CDM) were investigated in male and female rats. The focus population was examined for two histochemical markers,...

journal_title：Cancer letters

authors： Peraino C,Haugen DA,Carnes BA,Reilly CA Jr,Springer DL,Mahlum DD

更新日期：1987-10-30 00:00:00

abstract：:Aberrant activation of mammalian target of rapamycin complex 1 (mTORC1), caused by loss or inactivation of TSC1/TSC2 protein complex, leads to negative feedback inhibition of Akt. The exact mechanisms of this process are still not fully understood. Here we present evidence for the involvement of STAT3, a known mTORC1 ...

journal_title：Cancer letters

authors： Zha X,Hu Z,He S,Wang F,Shen H,Zhang H

更新日期：2011-12-27 00:00:00

abstract：:MUTYH-associated polyposis (MAP) is an autosomal recessive condition predisposing to colorectal cancer, caused by constitutional biallelic mutations in the base excision repair (BER) gene MUTYH. Colorectal tumours from MAP patients display an excess of somatic G>T mutations in the APC and KRAS genes due to defective B...

journal_title：Cancer letters

authors： Tricarico R,Bet P,Ciambotti B,Di Gregorio C,Gatteschi B,Gismondi V,Toschi B,Tonelli F,Varesco L,Genuardi M

更新日期：2009-02-18 00:00:00

abstract：:Soil samples were collected from the ground under the plants of Euphorbiaceae and Thymelaeaceae known to possess Epstein-Barr virus-activating diterpene esters. In a test system, the ether extracts of such soil samples at a concentration of 20 micrograms/ml induced Epstein-Barr virus early antigen in approximately 5-2...

journal_title：Cancer letters

authors： Ito Y,Ohigashi H,Koshimizu K,Yi Z

更新日期：1983-06-01 00:00:00

abstract：:Tumor biopsies obtained from 25 Saudi Arab patients with nasopharyngeal carcinoma (NPC) were examined for the presence of Epstein-Barr virus (EBV) DNA detected by the polymerase chain reaction (PCR) and for the incidence of p53 mutations screened by a combination of PCR, single strand conformation polymorphism (SSCP) ...

journal_title：Cancer letters

authors： Nasrin N,Taiba K,Hannan N,Hannan M,al-Sedairy S

更新日期：1994-07-29 00:00:00

abstract：:Several natural phenolic compounds were tested in vitro for their effect on the activity of protein kinase C isolated from liver cytosol, particulate and nuclear fractions of normal and aflatoxin B1 treated rats. Quercetin and kaempferol inhibited the enzyme activity of all these fractions at very low dose levels. The...

journal_title：Cancer letters

authors： Mistry KJ,Krishna M,Bhattacharya RK

更新日期：1997-12-16 00:00:00

abstract：:Upregulation of serine biosynthesis pathway activity is an increasingly apparent feature of many cancers. Most notably, the first rate-limiting enzyme of the pathway, phosphoglycerate dehydrogenase (PHGDH), is genomically amplified in some melanomas and breast cancers and can be transcriptionally regulated by various ...

journal_title：Cancer letters

authors： Li AM,Ye J

更新日期：2020-04-28 00:00:00

abstract：:Ten non-synonymous single nucleotide polymorphisms (nsSNPs), which were recently associated with colorectal cancer risk in a comprehensive, array based study (AKAP9 M463I, DKK3 G335R, AMPD1 Q12X, LIPC L356F, PSMB9 V32I, THBS1 N700S, CA6 S90G, ASCC3 C1995S, DHX36 S416C and CPA4 G303C) were re-evaluated in the present s...

journal_title：Cancer letters

authors： Frank B,Burwinkel B,Bermejo JL,Försti A,Hemminki K,Houlston R,Mangold E,Rahner N,Friedl W,Friedrichs N,Buettner R,Engel C,Loeffler M,Holinski-Feder E,Morak M,Keller G,Schackert HK,Krüger S,Goecke T,Moeslein G,Kloo

更新日期：2008-11-18 00:00:00

abstract：:N-Nitrosodiethanolamine (NDE1A) was administered by gavage to male rats in single doses of 1000, 500 and 100 mg/kg body wt. More than 70% of a given dose was excreted unchanged in the urine, essentially within the first 24 h after exposure. This high excretion rate might explain the relatively low carcinogenic potenti...

journal_title：Cancer letters

authors： Preussmann R,Würtele G,Eisenbrand G,Spiegelhalder B

更新日期：1978-04-01 00:00:00

abstract：:The mammary carcinogenicity of two diol epoxide metabolites of the commonly occurring environmental carcinogen benzo[j]fluoranthene (BjF) was investigated by direct application to the tissue beneath the mammary glands of female CD rats. The compounds tested were trans-4,5-dihydroxy-anti-6,6a.epoxy-4,5,6,6a-tetrahydroB...

journal_title：Cancer letters

authors： Hecht SS,Rivenson A,Amin S,Krzeminski J,el-Bayoumy K,Reddy BS,Kurtzke C,La Voie EJ

更新日期：1996-09-10 00:00:00

abstract：:MDM2 is a phosphoprotein that interacts with P53 and inhibits its activity. Recently, a T/G substitution (SNP309) in the promoter of MDM2 was identified and has been demonstrated to be associated with an increased MDM2 expression and a significantly earlier age of onset of several tumors, including breast cancer. To t...

journal_title：Cancer letters

authors： Ma H,Hu Z,Zhai X,Wang S,Wang X,Qin J,Jin G,Liu J,Wang X,Wei Q,Shen H

更新日期：2006-08-28 00:00:00

abstract：:Resistance to anoikis is a hallmark of human malignancies. Our results showed that hepatoma cells resisted anoikis by non-proliferation, non-apoptosis and cell cycle arrest which were termed synoikis-like. These synoikis-like cells are more resistant to extracellular stimuli and could spontaneously attach and prolifer...

journal_title：Cancer letters

authors： Zhang Z,Cao L,Li J,Liang X,Liu Y,Liu H,Du J,Qu Z,Cui M,Liu S,Gao L,Ma C,Zhang L,Han L,Sun W

更新日期：2008-08-18 00:00:00

abstract：:Cancers of the gastrointestinal (GI) tract continue to represent a major health problem, despite progress in therapy. Gut microbiota is a key element related to the genesis of GI cancers, countless papers addressing this burning issue across the world. We provide an updated knowledge of the involvement of gut microbio...

journal_title：Cancer letters

authors： Serban DE

更新日期：2014-04-10 00:00:00

abstract：:Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver cancer. Appropriate treatment of this aggressive and heterogeneous cancer requires accurate staging and prognostic stratification, as does patient selection for clinical trials. Over the past two decades, several staging systems and prognost...

journal_title：Cancer letters

authors： Cheng Z,Lei Z,Shen F

更新日期：2019-09-28 00:00:00

abstract：:We describe the events triggered by a sub-lethal concentration of airborne particulate matter (PM(10)) in A549 cells, which include the formation DNA double-strand breaks, gammaH2A.X generation, and 53BP1 recruitment. To protect the genome, cells activated ATM/ATR/Chk1/Chk2/p53 pathway but, after 48 h, cells turned in...

journal_title：Cancer letters

authors： Sánchez-Pérez Y,Chirino YI,Osornio-Vargas ÁR,Morales-Bárcenas R,Gutiérrez-Ruíz C,Vázquez-López I,García-Cuellar CM

更新日期：2009-06-18 00:00:00

abstract：:A novel iron chelator, HDp44mT, has been reported to have potent anti-proliferative effects on cancer cells; however, the underlying mechanism of action is not well understood. In this study, we characterized the cytotoxic effect of HDp44mT in a chemo- and radio-resistant cell line (PC-3) of prostatic cancer origin. T...

journal_title：Cancer letters

authors： Tian J,Peehl DM,Zheng W,Knox SJ

更新日期：2010-12-08 00:00:00

abstract：:The cooking of meat and fish produces heterocyclic amine mutagens, including 2-amino-1-methyl-6-phenylimidazo[4,5b]pyridine (PhIP) and 2-amino-3-methylimidazo[4,5-f]quinoline (IQ). Chronic administration of PhIP or IQ to the F344 rat induces tumors at several sites, including adenocarcinomas of the colon, and short-te...

journal_title：Cancer letters

authors： Xu M,Dashwood RH

更新日期：1999-09-01 00:00:00

abstract：:The di-methyl-, di-ethyl-, di-propyl-, di-normal butyl-, and di-iso-butyl-ethers of hematoporphyrin were synthesized and shown to possess chromatographic properties similar to those of the tumorlocalizing components of hematoporphyrin derivative (Hpd). The cellular uptake of these ethers, as well as their retention in...

journal_title：Cancer letters

authors： Moan J,Rimington C,Sommer S

更新日期：1987-03-01 00:00:00

abstract：:A variety of metal-binding compounds have been found to exert anti-cancer activity. We postulated that N-acetylcysteine (NAC), which is a membrane-permeable metal-binding compound, might have anti-cancer activity in the presence of metals. We found that NAC/Cu(II) significantly alters growth and induces apoptosis in h...

journal_title：Cancer letters

authors： Zheng J,Lou JR,Zhang XX,Benbrook DM,Hanigan MH,Lind SE,Ding WQ

更新日期：2010-12-08 00:00:00

abstract：:A direct relationship exists between aging and increasing incidences of chronic diseases. In fact, with most age-associated diseases individuals manifest an underlying chronic inflammatory state as evidenced by local infiltration of inflammatory cells, such as macrophages, and higher circulatory levels of pro-inflamma...

journal_title：Cancer letters

authors： Sarkar D,Fisher PB

更新日期：2006-05-08 00:00:00

abstract：:We have developed a monoclonal antibody (designated 1D7) which recognizes an M(r) 7-kDa plasma membrane protein overexpressed in ovarian MDR cancer cells. The expression of the M(r) 7-kDa protein in various human multidrug-resistant and drug-sensitive cell lines was analysed by Western blot and flow cytometry methods....

journal_title：Cancer letters

authors： Yang X,Pagé M

更新日期：1995-01-27 00:00:00

abstract：:Bacteria are always a considerable tool for the cancer therapy. The bacteria-derived minicells are re-emerged as a promising drug delivery system for cancer therapy. The minicells are nano-sized, anucleated, non-dividing, and metabolically active cells produced by abnormal bacterial cell division that are able to tran...

journal_title：Cancer letters

authors： Ali MK,Liu Q,Liang K,Li P,Kong Q

更新日期：2020-10-28 00:00:00

abstract：:The ability to recognize and respond to universal molecular patterns on invading microorganisms allows our immune system to stay on high alert, sensing danger to our self-integrity. Our own damaged cells and tissues in pathological situations activate similar warning systems as microbes. In this way, the body is able ...

journal_title：Cancer letters

authors： Ratikan JA,Micewicz ED,Xie MW,Schaue D

更新日期：2015-11-28 00:00:00

abstract：:The kinetics of total DNA adducts were compared in the liver, bladder epithelium and small intestinal epithelium of rats and mice following a single oral dose (100 mg/kg) of 3,3'-dichlorobenzidine [( 14C]DCB). Peak DNA binding (expressed as pmol DCB bound/mg DNA) in rat tissues was 153.5, 144.8 and 36.9 in the intesti...

journal_title：Cancer letters

authors： Ghosal A,Iba MM

更新日期：1990-09-01 00:00:00