Abstract：
:Exposure of HeLa cells to 0, 5, 10, 25, 50 and 100 microg/ml of guduchi extracts (methanol, aqueous and methylene chloride) resulted in a dose-dependent but significant increase in cell killing, when compared to non-drug-treated controls. The effects of methanol and aqueous extracts were almost identical. However, methylene chloride extract enhanced the cell killing effect by 2.8- and 6.8-fold when compared either to methanol or aqueous extract at 50 and 100 microg/ml, respectively. Conversely, the frequency of micronuclei increased in a concentration-dependent manner in guduchi-treated groups and this increase in the frequency of micronuclei was significantly higher than the non-drug-treated control cultures and also with respect to 5 microg/ml guduchi extract-treated cultures, at the rest of the concentrations evaluated. Furthermore, the micronuclei formation was higher in the methylene chloride extract-treated group than in the other two groups. The dose response relationship for all three extracts evaluated was linear quadratic. The effect of guduchi extracts was comparable or better than doxorubicin treatment. The micronuclei induction was correlated with the surviving fraction of cells and the correlation between cell survival and micronuclei induction was found to be linear quadratic. Our results demonstrate that guduchi killed the cells very effectively in vitro and deserves attention as an antineoplastic agent.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Jagetia GC,Nayak V,Vidyasagar MSdoi
10.1016/s0304-3835(98)00047-0subject
Has Abstractpub_date
1998-05-15 00:00:00pages
71-82issue
1-2eissn
0304-3835issn
1872-7980pii
S0304-3835(98)00047-0journal_volume
127pub_type
杂志文章相关文献
CANCER LETTERS文献大全abstract：:The traditional anti-angiogenic cancer therapy could trigger hypoxia induced factor (HIF) response, leading to "reactive resistance" to chemotherapy. Simultaneously inhibiting both angiogenesis and tumorigenesis would be ideal to overcome this limitation. MicroRNAs (miRNAs) are increasingly explored as new agents for ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2017.03.032
更新日期：2017-07-01 00:00:00
abstract：:Membrane glycoprotein synthesis was studied in non-tumorigenic and tumor cells treated with the lymphokine hormone, lymphotoxin, to define the biochemical mechanisms by which lymphotoxin prevents carcinogenesis and inhibits growth of tumor cells. Syrian hamster lymphotoxin increased the synthesis of high molecular wei...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(83)90096-4
更新日期：1983-07-01 00:00:00
abstract：:The tumor microenvironment (TME) of lung cancer has been documented to play an important role in participating in tumor disease progression. As the precursor of most stroma in TME, mesenchymal stem cells (MSCs) draw great attention since evidence has suggested that MSCs derived from lung cancer patients present a diff...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2014.07.047
更新日期：2014-10-28 00:00:00
abstract：:The present study was performed to investigate the possible role of mTOR inhibitors in restoring chemosensitivity to adriamycin/cisplatin and elucidate the underlying mechanism. Combining adriamycin/cisplatin with torisel synergistically inhibited the cell proliferation in human oropharyngeal carcinoma cell line KB an...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2011.06.005
更新日期：2011-12-01 00:00:00
abstract：:High doses of folate and its quinazoline analogue with antitumour activity, N10-propargyl-5,8-dideazafolic acid (CB 3717), caused severe renal damage in mice, leading in the case of folate to death. The mouse kidneys increased in weight, which was accompanied by time- and dose-dependent induction of ornithine decarbox...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(91)90147-a
更新日期：1991-09-01 00:00:00
abstract：:The age-standardized mortality rates by sex for cancer of all sites and some specific sites were calculated in the 22 areas of Rosario (Argentina). The rates by area were correlated with education, occupation, housing quality and population density, applying Kendall's tau. Cervical cancer rates showed the strongest co...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(90)90159-u
更新日期：1990-03-01 00:00:00
abstract：:To shed light on the association of intestinal microflora with the development of colon cancer, we studied the modifying effects of intestinal microflora on the occurrence of 1,2-dimethylhydrazine (DMH)-induced colonic aberrant crypt foci (ACF) in germfree (GF), gnotobiotic (GB) and conventionalized (Cvd) rats. In the...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(97)04698-3
更新日期：1997-02-26 00:00:00
abstract：:Telomerase activity (TA) and telomerase reverse transcriptase (rTERT) were investigated in Sprague-Dawley rats, killed at 6 and 12 h, and 1, 2, 3, 7, and 14 days after 90% pancreatectomy (px), by TRAPeze enzyme-linked immunosorbent assay telomerase detection and reverse transcriptase-polymerase chain reaction. TA incr...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(02)00320-8
更新日期：2002-12-01 00:00:00
abstract：:We investigated the role of the 5-lipoxygenase (5-LOX) pathway of arachidonic acid metabolism in tumour necrosis factor-alpha (TNF-alpha)-induced differentiation of human leukemic HL-60 cells using MK-886, an inhibitor of 5-LOX activating protein. MK-886 augmented cell cycle arrest and differentiation induced by TNF-a...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2005.06.012
更新日期：2006-06-18 00:00:00
abstract：:We demonstrate herein the ability of transforming growth factor-beta-2 (TGFbeta2) to potently activate extracellular signal-regulated kinase 2 (ERK2) in the highly TGFbeta-sensitive breast cancer cell (BCC) line Hs578T. The ERK2 isoform was activated by 3-fold within 5 min of TGFbeta2 addition to Hs578T cells. However...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(97)00211-5
更新日期：1997-07-15 00:00:00
abstract：:Transforming growth factors (TGFs) are implicated in malignancy, therefore qualitative and quantitative differences of these growth factors in chronic myelogenous leukemia (CML) in chronic phase has been investigated in this report. Induction of anchorage independent growth of BALB/c 3T3 and NRK-49F fibroblasts was us...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(86)90181-3
更新日期：1986-09-01 00:00:00
abstract：:Metastasis is a characteristic and fatal feature of human malignancies. Its regulation is therefore of the utmost significance to clinicians. The present study was undertaken to determine whether a legume-derived protease inhibitor (PI) of trypsin/chymotrypsin, the field bean PI (FBPI), also has plasmin inhibitory act...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(98)00090-1
更新日期：1998-07-03 00:00:00
abstract：:A common germline polymorphism of p53 gene produces an Arginine to Proline change at aminoacid position 72. The resulting codon 72 variants have been reported associated with tumor susceptibility since they reduce p53 ability to activate apoptosis. Codon 72 polymorphism may play a role in subside vulnerability to diff...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2004.01.016
更新日期：2004-07-16 00:00:00
abstract：:Given its contribution to malignant phenotypes of cancer, tumor hypoxia has been considered as a potential therapeutic problem. In the stressful microenvironment condition, hypoxia inducible factor 1 (HIF1) is well known to mediate the transcriptional adaptation of cells to hypoxia and acts as a central player for the...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2014.07.048
更新日期：2014-11-01 00:00:00
abstract：:We investigated the effects of the ethyl acetate extract of grapefruit juice (GFJ), that of orange juice (OJ) and their components on the uptake of [(3)H]vincristine into adriamycin-resistant human myelogenous leukemia cells. Its uptake was increased by the extracts of GFJ and OJ up to 7- and 3-fold, respectively, as ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(00)00549-8
更新日期：2000-11-10 00:00:00
abstract：:Pancreatic adenocarcinoma cells show characteristics of macrophages as phagocytosis and exocytosis. These phagocytic activities can be inhibited in macrophages by antirheumatic drugs, e.g. gold compounds and antimalarials. We have now tested the activity of auranofin and chloroquine to inhibit growth of a pancreatic t...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(89)90109-2
更新日期：1989-01-01 00:00:00
abstract：:Only physiological levels of melatonin exert an antiproliferative effect on MCF-7 breast cancer cells grown in an anchorage-dependent culture system. We investigated melatonin's effect on the anchorage-independent growth of MCF-7 cells as well as the dose-response characteristics of this indoleamine under clonogenic c...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(90)90240-x
更新日期：1990-04-20 00:00:00
abstract：:Cancer cachexia patients experience significant muscle wasting, which impairs the quality of life and treatment efficacy for patients. Skeletal muscle protein turnover is imparted by increased expression of ubiquitin-proteasome pathway components. Mitogen-activated protein kinases p38 and ERK have been shown to augmen...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2020.07.025
更新日期：2020-10-28 00:00:00
abstract：:Apoptosis is a gene-directed program that is engaged to efficiently eliminate dysfunctional cells. Evasion of apoptosis may be an important gate to tumor initiation and therapy resistance. Like any other developmental program, apoptosis can be disrupted by several genetic aberrations driving malignant cells into an un...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2016.05.012
更新日期：2016-08-10 00:00:00
abstract：:Fibronectin concentration was determined in plasma from 97 patients with benign or malignant breast disease and from 62 controls. Median plasma fibronectin concentration (microgram FN/ml plasma) appeared to be significantly higher in patients with non-metastatic or metastatic breast cancer as compared to age-matched c...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(86)90071-6
更新日期：1986-12-01 00:00:00
abstract：:Co-transfer of immunomodulatory and antiproliferative genes may be the basis for new strategies to potentiate tumor regression. In this study, we evaluated the in vitro effect of the introduction of human wild-type p53, granulocyte-macrophage colony-stimulating factor (GM-CSF), and B7-1 genes via recombinant adenoviru...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(02)00089-7
更新日期：2002-08-28 00:00:00
abstract：:Tumor angiogenesis is a critical step for the growth and metastasis of solid tumors. Vascular endothelial growth factor (VEGF) is the most important angiogenic molecule associated with tumor-induced neovascularization. VEGF exerts its activity through binding to its receptor tyrosine kinase, KDR/Flk-1, expressed on th...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2003.11.008
更新日期：2004-05-10 00:00:00
abstract：:Serum alpha-N-acetylgalactosaminidase (NaGalase) is responsible for the deglycosylation of vitamin D(3)-binding protein (Gc protein). The deglycosylated Gc protein cannot be converted into major macrophage-activating factor (MAF), leading to immunosuppression. NaGalase is universally detected in a variety of cancer pa...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(00)00502-4
更新日期：2000-09-29 00:00:00
abstract：:Cancer-associated fibroblasts (CAFs) are the predominant cell type in tumor microenvironment (TM) and featured with the distinct energy metabolism reprogramming (EMR) phenotype caused by many factors such as hypoxia and growth factors. The EMR of CAFs plays a key role in biological behaviors of cancer cells including ...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2014.07.028
更新日期：2014-10-28 00:00:00
abstract：:The influence of the carcinogen 2-acetylaminofluorene (2AAF) administration on splenic natural killer (NK) cell function in two strains of rats has been examined and compared with that of the non-carcinogenic analogue 4-acetylaminofluorene (4AAF). In both strains it was observed that daily exposure to 25 mg kg-1 2AAF ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(86)90130-8
更新日期：1986-01-01 00:00:00
abstract：:R-spondins play critical roles in development, stem cell survival, and tumorigenicity by modulating Wnt/β-catenin signaling; however, the role of R-spondins in noncanonical Wnt signaling regulation remains largely unknown. We demonstrate here that R-spondin 2 (RSPO2) has an inhibitory effect on colorectal cancer (CRC)...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2017.05.024
更新日期：2017-08-28 00:00:00
abstract：:The modifying effects of nonylphenol and genistein on cancer induction were assessed in a multi-organ carcinogenesis model in male F344 rats initially treated with five different carcinogens. In experiment 1 rats received 250 or 25 ppm nonylphenol, or 250 or 25 ppm genistein in their diet for 28 weeks. The total incid...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(02)00684-5
更新日期：2003-03-20 00:00:00
abstract：:Azelaic acid has been shown to inhibit thioredoxin reductase (TR) at the surface of guinea pig and human skin, on cultures of human keratinocytes, melanocytes, melanoma cells, murine melanoma cells (Cloudman S91), and on purified enzymes from Escherichia coli, rat liver, and human melanoma. Human melanoma cells are mo...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(87)90023-1
更新日期：1987-09-01 00:00:00
abstract：:Based on the primer binding site for Phe-tRNA, human endogenous retroviruses (HERVs) have been classified as HERV-F family members, HERV-F, HERV-FXA, HERV-Fb, and HERV-Fc. The HERV-F family was expressed in human placenta preferentially. We investigated pol fragments of HERV-F family in various human tissues and cance...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2004.01.026
更新日期：2004-07-28 00:00:00
abstract：:Although docetaxel significantly improves survival in a variety of malignancies, its clinical utility is severely restricted by acquired chemoresistance and disease relapse. To uncover the mechanisms underlying these all too common occurrences, an abundance of research has focused on mutations and gene expression patt...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2015.06.025
更新日期：2015-10-28 00:00:00
