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Expression of lysophosphatidic acid receptors and vascular endothelial growth factor mediating lysophosphatidic acid in the development of human ovarian cancer.

Abstract：

:Lysophosphatidic acid (LPA) receptors including LPA(1), LPA(2), and LPA(3) mediate lysophosphatidic acid signals. We analyzed the expression of LPA receptors, vascular endothelial growth factor (VEGF), and interleukin-8 in 97 patients from normal ovary to ovarian cancer, using reverse transcription polymerase chain reaction. LPA(2), LPA(3), and VEGF expression ratios significantly increased in cancer, compared to those in non-cancerous state (P<0.05). A significant correlation in the expression ratios between LPA(2) or LPA(3) and VEGF was found (gamma=0.617, P<0.0001; gamma=0.431, P<0.001) in patients with cancer. These results suggested that LPA(2) and LPA(3) may be involved in VEGF expression mediated by LPA signals in human ovarian oncogenesis.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Fujita T,Miyamoto S,Onoyama I,Sonoda K,Mekada E,Nakano H

doi

10.1016/s0304-3835(02)00713-9

keywords:

subject

Has Abstract

pub_date

2003-03-31 00:00:00

pages

161-9

issue

2

eissn

0304-3835

issn

1872-7980

pii

S0304383502007139

journal_volume

192

pub_type

杂志文章

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