Abstract:
:A high-pressure liquid chromatographic (HPLC) method using a micro-particulate silica column and gradient elution was developed that separated 12-O-tetradecanoylphorbol-13-acetate (TPA) from 20-oxo-TPA; 12-O-tetradecanoylphorbol (TP); 13-O-acetylphorbol (PA), and from the diterpene alcohol, phorbol (P). A series of other phorbol-ester tumor promoters were also separated via HPLC. Spectrophotometric determination at 232 nm allowed detection sensitivities of 0.05 microgram of TPA. When tritiated TPA was applied to mouse skin, the majority of the tritiated product recovered was TPA, indicating only minimal metabolism of TPA and no need for metabolic activation for tumor promotion.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Berry DL,Lieber MR,Fischer SM,Slaga TJdoi
10.1016/s0304-3835(77)94943-6subject
Has Abstractpub_date
1977-09-01 00:00:00pages
125-32issue
3-4eissn
0304-3835issn
1872-7980pii
S0304-3835(77)94943-6journal_volume
3pub_type
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