Abstract:
:Matrix Gla protein (MGP) is a vitamin K-dependent extracellular matrix protein commonly found in a variety of tissues. In this study, we describe the potential use of MGP gene expression as the tumor marker of colorectal cancer. A decrease in expression of the MGP gene was also discovered in colorectal cancer using differential screening of cDNA libraries. The MGP expression in 80 human colorectal adenocarcinomas was quantified by a Northern blot analysis to better define the expression pattern of MGP in colorectal cancer. The expression of MGP mRNA was reduced in 63 of 80 (79%) colorectal adenocarcinomas (P<0.001) as compared to the mRNA in adjacent normal tissue, implying that a decrease in MGP expression is associated with colorectal cancer development. The proportion of tumors with downregulated expression of MGP was lower in Duke's A/B than Duke's C/D (34 of 47 versus 26 of 33, respectively) tumors and was lower in moderate differentiation than poor differentiation (44 of 64 versus 16 of 16, respectively). However, chi(2) analysis does not reveal any correlation between a loss of MGP expression and tumor progression or differentiation state. In conclusion, the downregulation of MGP mRNA generally occurs in colorectal adenocarcinomas. Although the role of MGP in cancer development is unknown, the reduced expression of MGP may be used to distinguish the normal colorectal cells from malignant cells.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Fan C,Sheu D,Fan H,Hsu K,Allen Chang C,Chan Edoi
10.1016/s0304-3835(01)00416-5keywords:
subject
Has Abstractpub_date
2001-04-10 00:00:00pages
63-9issue
1eissn
0304-3835issn
1872-7980pii
S0304383501004165journal_volume
165pub_type
杂志文章相关文献
CANCER LETTERS文献大全abstract::Large marker chromosomes were found in 2 hormone-independent (HI) GR mouse mammary tumors, i.e. a tumor (TSl 75) that was already HI at the first transplantation, and a tumor (TSl 66) that became HI at the 19th passage. These marker chromosomes appear to be translocations to distal and proximal ends of chromosome 1, r...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(85)90109-0
更新日期:1985-06-01 00:00:00
abstract::Low-frequency electromagnetic fields enhance the induction of mammary gland tumors in rats using nitrosomethyl urea. The incidence of tumors depended on the duration of exposure to static (dc) and variable (ac) magnetic fields. Variable magnetic fields induced mammary gland cancer much more frequently than static ones...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(91)90079-w
更新日期:1991-12-09 00:00:00
abstract::Corynebacterium parvum was investigated in the response of rat Mc7 sarcoma to local waterbath hyperthermia. Heat treatment of 1-1.5 cm3 foot tumors at 43 degrees C for 2 h resulted in complete regression of 71% of the tumors. The Mc7 cure was reduced to 31% when the tumors were heated at 43 degrees C for 1.5 h. C. par...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(85)90031-x
更新日期:1985-03-01 00:00:00
abstract::Colorectal cancer (CRC) is a commonly diagnosed malignancy with unsatisfactory survival outcomes. Recent studies indicate that noncoding RNAs (ncRNAs) can be selectively packaged into exosomes, the extracellular vesicles composed of a lipid bilayer, and delivered from donor to recipient cells, thus regulating the beha...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2020.08.037
更新日期:2020-11-28 00:00:00
abstract::Cancer results from the interaction of multiple aberrations including activation of dominant oncogenes and upregulation of signal transduction pathways. Identification of the genes involved in malignant transformation is a pre-requisite for understanding cancer and improving its diagnosis and treatment. Quite a few of...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2007.04.015
更新日期:2007-10-08 00:00:00
abstract::BRCA2-associated pancreatic ductal adenocarcinoma (PDAC) may be sensitive to agents that target homology-directed DNA repair, such as DNA crosslinking agents (DCLs) and PARP inhibitors (PARPis). Here, we assessed the sensitivities of BRCA2-deficient (Capan-1) and BRCA2-proficient (MIA PaCa-2) PDAC cell lines to a pane...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2015.04.003
更新日期:2015-08-01 00:00:00
abstract::Many clinical studies have shown that circulating RNA rises in cancer patients, but little is known about the origins of abnormally elevated extracellular RNA (exRNA). We designed four different culture conditions: serum-deprived, hypoxia, low temperature and exposure to an anticancer drug to investigate the origins i...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2007.09.016
更新日期:2008-01-18 00:00:00
abstract:AIM:the ability of the breast cancer-associated placental acid isoform of ferritin (p43-PLF) to modulate cell surface expression of HLA, CD59 (protectin) and CD66 antigen (adhesion antigen related to CEA) was examined. METHODS:the expression of these antigens in human breast carcinoma cell lines BT-20, T47D and MDA-MB...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(95)03831-g
更新日期:1995-07-20 00:00:00
abstract::Residential radon exposure is considered the second cause of lung cancer and the first in never smokers. Nevertheless, the association between the different histological types of lung cancer and radon is not completely clear, and radon effect on small cell lung cancer is not completely understood. We aim to asses the ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2018.04.003
更新日期:2018-07-10 00:00:00
abstract::As a cellular degradation mechanism, autophagy exerts crucial and complicated effects on HCC development. Liver non-parenchymal cells, including hepatic resident macrophage Kupffer cells, also play important roles in this process. However, most associated studies have focused on the influence of the autophagy level in...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.12.004
更新日期:2017-03-01 00:00:00
abstract::N-Acetyltransferase activities with p-aminobenzoic acid and 2-aminofluorene were determined in Anisakis simplex, a nematode found in the intestine of the salt water fish Trichiurus lepturus. The N-acetyltransferase activity was determined using an acetyl CoA recycling assay and high pressure liquid chromatography. The...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(96)04288-7
更新日期:1996-08-23 00:00:00
abstract::Expression of the MUC2 gene is controlled by the methylation of CpG sites in the promoter region, but the detailed methylation status of this region has yet to be reported. We have mapped the complete methylation status of the MUC2 promoter from position -1989 to position +288 upstream, a region that contains 59 CpG s...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2004.11.058
更新日期:2005-09-28 00:00:00
abstract::To investigate characteristic of lung adenocarcinoma growth behavior, we have established a cell line (rat lung cancer in Nara (RLCNR)) from a tumor induced by N-nitrosobis(2-hydroxypropyl)amine (BHP) in a rat. This clone shows an epithelial cell morphology and grows as sheets in culture with an approximate doubling t...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2004.06.034
更新日期:2005-01-10 00:00:00
abstract::The effect of ligation of the left ureter on the development of lesions in the urinary bladder were investigated in male F344 rats treated with 0.05% N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) for 2 weeks followed by 0.002% N-ethyl-N-(4-hydroxybutyl)nitrosamine (EHBN) for 10 or 22 weeks. The lesions of the urinary b...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(84)90093-4
更新日期:1984-07-01 00:00:00
abstract::Glioma is one of most malignant primary tumors of the brain. However, due to a lack of effective means for diagnosing and treating glioma, the prognosis of glioma patients remains poor. Therefore, understanding the molecular mechanism of glioma progression is essential for effective treatment. Long non-coding RNAs (ln...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2018.01.041
更新日期:2018-04-10 00:00:00
abstract::In order to examine the in vivo genotoxic activity of dichlorvos, lambdalacZ transgenic mice (Muta Mouse) were treated i.p. with single (4.4 or 11 mg/kg) or multiple (5 x 11 mg/kg) doses of this agent and sacrificed 4 h or 14 days post-treatment for DNA adduct measurement or mutant frequency analysis, respectively. Ne...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(99)00256-6
更新日期:1999-11-15 00:00:00
abstract::Heterocyclic amines (HCAs) present in cooked foods are suggested to be involved in human breast cancer development. Estrogen plays a pivotal role in mammary gland carcinogenesis. Therefore, we designed an in vivo experiment to investigate potential estrogenic effects of two HCAs, 2-amino-3-methylimidazo[4,5-f]quinolin...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(00)00626-1
更新日期:2001-01-10 00:00:00
abstract::The p53 mutations in betel-related oral cancer have been studied but the results may be confounded by tobacco and alcohol due to tobacco components in the quid or concomitant habits of smoking and drinking. In this study, p53 mutations in tumors from Thai betel chewers who neither smoke nor drink were studied in compa...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(03)00417-8
更新日期:2003-11-10 00:00:00
abstract::The B16 malignant melanoma and its F1 variant line were described and compared in syngeneic C57BL/6 mice at short and long term periods after transplantation. No observable differences in gross or histological features were noted. In both lines, liver and lung metastasis was confirmed and kidney colonization proposed....
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(84)90080-6
更新日期:1984-08-01 00:00:00
abstract::CD271, known as a neurotrophin receptor, is expressed in various cancers such as hypopharyngeal cancer (HPC) and melanoma. We recently reported that CD271 is a cancer-stem-cell biomarker of HPC, and that its expression is essential for cancer-cell proliferation and is correlated with a poor prognosis in this disease. ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2019.07.011
更新日期:2019-10-01 00:00:00
abstract::Gastrin-releasing peptide (GRP) activates phosphatidylinositol 3-kinase (PI3-K)/Akt, an important cell survival signaling pathway, to stimulate growth of various cell types. Transforming growth factor (TGF) superfamily ligands activate intracellular Smad signaling to regulate cell growth, differentiation and apoptosis...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2005.11.007
更新日期:2006-10-28 00:00:00
abstract::The (32)P-postlabelling method for the analysis of carcinogen-DNA adducts originated 30years ago from Baylor College of Medicine in Houston and was the work of a team comprised of Kurt and Erica Randerath, Ramesh Gupta and Vijay Reddy. With subsequent modifications and developments, it has become a highly sensitive an...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2012.11.027
更新日期:2013-06-28 00:00:00
abstract::We measured colonic effluent samples from 10 patients with colorectal cancer, 13 with adenomatous polyps, 14 with normal colons and compared them to 10 patients with inflammatory bowel disease by measuring this CA19-9 content. Results showed considerable overlap between the different pathologic categories, making diff...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(91)90043-h
更新日期:1991-10-01 00:00:00
abstract::Because lipoperoxides seem able to modulate tumor growth, we have examined the concomitant effects of dietary antioxidant (vitamin E) and of a high amount of polyunsaturated fatty acids (PUFA) in a model of chemically-induced mammary carcinogenesis. Two groups of rats received a high fat diet with or without added vit...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(97)04671-5
更新日期:1997-03-19 00:00:00
abstract::We have established three cloned cell lines (COS1NR, COS2NR and COS4NR) from the lung metastatic nodule of a highly metastatic variant of rat transplantable osteosarcoma, C-SLM. All three clones shared the same morphological characteristics and tumorigenicity, but their growth rates in vitro and metastatic ability in ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(98)00048-2
更新日期:1998-05-15 00:00:00
abstract::A tissue field of somatic genetic alterations precedes the histopathological phenotypic changes of carcinoma. Genomic changes could be of potential use in the diagnosis and prognosis of pre-invasive squamous head and neck carcinoma (HNSCC) lesions and as markers for cancer risk assessment. Studies of sequential molecu...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2012.02.018
更新日期:2014-01-28 00:00:00
abstract::The incidence of carcinomas highly increases with age. However, the initial steps of the age-related molecular carcinogenic processes remain poorly characterized. We previously showed that normal human epidermal keratinocytes spontaneously and systematically escape from senescence to give rise to preneoplastic emergin...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2018.09.008
更新日期:2018-12-01 00:00:00
abstract::The thiol N-acetylcysteine (NAC), a precursor of intracellular glutathione (GSH), efficiently prevented the induction of lung tumors in Swiss albino mice, when supplemented to the diet (0.2%) both before and after an i.p. injection of the carcinogen urethan (ethyl carbamate). Irrespective of urethan administration, NA...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(86)90175-8
更新日期:1986-09-01 00:00:00
abstract::The fruiting body of Antrodia camphorata is well known in Taiwan as a traditional medicine for treating cancer and inflammation. The purpose of this study was to evaluate the apoptotic effects of ethylacetate extract from A. camphorata (EAC) fruiting bodies in two human liver cancer cell lines, Hep G2 and PLC/PRF/5. T...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2004.08.012
更新日期:2005-04-18 00:00:00
abstract::A rabbit gamma delta killer T-cell line against Shope carcinoma cells was established from peripheral blood lymphocytes (PBL) of a human T-lymphotropic virus type I (HTLV-I)-infected rabbit bearing Shope papilloma and carcinoma. Southern hybridization analysis of this cell line with an HTLV-I probe showed that the cel...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(95)90155-8
更新日期:1995-02-10 00:00:00