Abstract：
:Birt-Hogg-Dubé (BHD) syndrome is a rare inherited genodermatosis characterized by benign hamartomatous skin lesions and an increased risk of pneumothorax and renal tumors. Many of the patients harbor insertion/deletion mutations in the hypermutable poly(C)(8) tract in exon 11 of the BHD gene. This mutational hot spot is also reported to be a target of mutation in microsatellite instability (MSI) sporadic colorectal tumors. To test if the BHD gene is a potential mutational target in gastric cancer, we screened for mutations in all of the coding exons of the BHD gene in 30 cases of MSI gastric cancer as well as 50 cases of microsatellite stable (MSS) gastric cancer. Mutations in the poly(C)(8) tract of BHD were detected in 3 of 19 MSI-high cases (15.8%), and none of 11 MSI-low cases. All BHD mutated cases also showed mutations of both BAX and TGFbetaRII. No mutations were detected in the other exons of the BHD gene. No BHD mutations were found in MSS gastric cancer cases. Taken together, these findings show that the BHD gene is a rare target in MSI-high gastric cancer, and BHD mutation tends to occur downstream in the mutational events of other major MSI-high target genes.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Jiang W,Fujii H,Matsumoto T,Ohtsuji N,Tsurumaru M,Hino Odoi
10.1016/j.canlet.2006.06.005subject
Has Abstractpub_date
2007-04-08 00:00:00pages
103-11issue
1eissn
0304-3835issn
1872-7980pii
S0304-3835(06)00409-5journal_volume
248pub_type
杂志文章相关文献
CANCER LETTERS文献大全abstract：:As myeloma cells actively produce and secrete immunoglobulins, they are prone to ER stress, which if unresolved leads to apoptosis. We found that myeloma cell death induced by the ER stressor Thapsigargin was highly variable, ranging from 2 to 89%. Induction of ATF4 and CHOP was observed in myeloma cells under Thapsig...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2016.09.030
更新日期：2016-12-28 00:00:00
abstract：:Starvation-induced hypoglycaemia and streptozotocin-induced diabetes suppressed the growth of Ehrlich ascites tumor in mice. The suppression of tumor growth by diabetes was alleviated by administration of insulin. The number of glucose carriers on tumour cells was found to be reduced in diabetes and partial resumption...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(85)90035-7
更新日期：1985-09-30 00:00:00
abstract：:In this study, we investigated the role of Ca(2+) in curcumin-induced paraptosis, a cell death mode that is accompanied by dilation of mitochondria and the endoplasmic reticulum (ER). Curcumin induced mitochondrial Ca(2+) overload selectively in the malignant breast cancer cells, but not in the normal breast cell, con...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2012.05.018
更新日期：2012-11-28 00:00:00
abstract：:Rats bearing the Yoshida AH-130 ascites hepatoma, a cachectic rat tumour, showed signs of important muscle wasting with reduced muscle weights. This phenomenon was associated with a decreased rate of in vivo alanine oxidation as measured by the production of 14CO2 from [U-14C]alanine intragastrically administered. It ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(94)90212-7
更新日期：1994-12-09 00:00:00
abstract：:To clarify the suitability of a newborn-mouse carcinogenesis assay to detect tumor-promoting activities of carcinogens, the non-genotoxic hydroquinone (HQ) and genotoxic 1,1-dimethylhydrazine (UDMH) were administered to mice during the promotion stage after treatment with 1-methyl-1-nitrosourea (MNU) (20 mg/kg body wt...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(99)00193-7
更新日期：1999-08-23 00:00:00
abstract：:In a comparative experimental study, excisions of a transplanted Lewis lung carcinoma in BDF1 mice were performed by means of the CO2 laser and conventional methods, namely common scalpel and diathermy. The results showed a significant reduction in tumor recurrence and animal mortality rates (27.5% vs. 75% and 45%) af...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(76)80009-2
更新日期：1976-09-01 00:00:00
abstract：:Human mitogen-stimulated lymphocytes, cultured in the presence of amosite asbestos (AS), demonstrated a slight increase in aryl hydrocarbon hydroxylase (AHH) activity compared with non-induced (control) cultures (P = 0.005). A much greater increase in enzyme activity occurred following addition of the inducers benzant...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(79)80113-5
更新日期：1979-07-01 00:00:00
abstract：:Adult T-cell leukemia (ATL) is a fatal malignancy caused by infection with human T lymphotropic virus type-1 (HTLV-1). To search for a new biomarker of ATL, we analyzed sera from ATL patients using ProteinChip arrays. The spectral comparison of ATL patients with HTLV-1 carriers and healthy volunteers showed that the i...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2008.06.004
更新日期：2008-11-18 00:00:00
abstract：:Administration of raw soya containing a trypsin inhibitor stimulated excessive release of cholecystokinin (CCK) which led to pancreatic hypertrophy, hyperplasia and cancer in the rats (Booth et al. (1964) Proc. Soc. Exp. Biol. Med., 116, 1067). More postprandial CCK release in healthy humans was observed after ingesti...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(95)03697-u
更新日期：1995-04-14 00:00:00
abstract：:Aristolochic acid (AA), a naturally occurring nephrotoxin and carcinogen, has been associated with the development of urothelial cancer in humans. Using the 32P-postlabeling assay we showed that AAI is activated by human recombinant cytochrome P450 (CYP) 1A1, CYP1A2 and NADPH:CYP reductase to species generating DNA ad...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2005.06.038
更新日期：2005-11-18 00:00:00
abstract：:The effects of caloric restriction on the incidence of mammary tumor development, the levels of the expression of mouse mammary tumor virus (MMTV)- and prolactin-RNA, as well as the levels of serum prolactin, were investigated in virgin RIII/Sa mice, a strain known to display a high incidence of spontaneous mammary tu...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(94)90261-5
更新日期：1994-05-16 00:00:00
abstract：:The acute intraperitoneal toxicities of chlorambucil and chlorambucil-spermidine conjugate have been compared, in mice. Both compounds were neurotoxic and also caused a prolonged fall in bodyweight and a depletion of lymphocyte numbers associated with a fall in the total leukocyte count and loss of spleen and thymus w...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(94)90278-x
更新日期：1994-10-14 00:00:00
abstract：:Low-frequency electromagnetic fields enhance the induction of mammary gland tumors in rats using nitrosomethyl urea. The incidence of tumors depended on the duration of exposure to static (dc) and variable (ac) magnetic fields. Variable magnetic fields induced mammary gland cancer much more frequently than static ones...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(91)90079-w
更新日期：1991-12-09 00:00:00
abstract：:Grp75 is a stress-inducible mitochondrial chaperone which has a high homology to senescence-related protein, p66mot mortalin. In human cells the mortalin gene assigns to the locus of a putative tumor suppressor gene for myeloid malignancies. In order to study expression and localization of Grp75 and p66mot in human an...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(97)00270-x
更新日期：1997-11-11 00:00:00
abstract：:The mutagenic activities of N-nitrosobis(2-hydroxypropyl)amine (BHP) and its related compounds were studied in Salmonella typhimurium TA100 and TA98 strains by Ames's liquid incubation assay in the presence or absence of lung and liver S9 of rats treated with polychlorinated biphenyl (PCB). BHP and its related compoun...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(83)90235-5
更新日期：1983-04-01 00:00:00
abstract：:Sprague-Dawley rats were injected weekly with either 1,2-dimethylhydrazine (DMH) or methylazoxymethanol acetate (MAM). Addition of 4 ppm selenium (sodium selenite) in the drinking water reduced the number of rats developing DMH-induced colon tumors from 13 to 6 groups of 15 each. The total number of tumors observed in...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(77)80002-5
更新日期：1977-01-01 00:00:00
abstract：:In this study, we investigated the antitumor effects of deguelin in several human breast cancer cells in vitro and in vivo. Deguelin inhibited cell viability and the anchorage-dependent and anchorage-independent colony formation of triple-negative (MDA-MB-231 and MDA-MB-468) and triple-positive (MCF-7) breast cancer c...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2013.01.022
更新日期：2013-05-10 00:00:00
abstract：:New, potentially tumor-specific antigens have been described in Bcr/Abl positive leukemias. Besides the main BCR/ABL hybrid fusion transcripts, a small number of transcripts derived from alternative splicing between BCR exons 1, 13, and 14 with ABL exons 4 and 5 have been identified. These variants are expressed in ch...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2008.10.032
更新日期：2009-04-08 00:00:00
abstract：:The sex-determining region Y-box 7 (Sox7) is a member of high mobility group (HMG) transcription factor family, essential for embryonic development and endoderm differentiation. Deregulation of Wnt signaling pathway is a hallmark of colorectal cancer. Our results showed that the expression level of SOX7 was frequently...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2008.11.014
更新日期：2009-05-08 00:00:00
abstract：:In experimental cancer chemoprevention studies, the doses of the agent used to produce an inhibitory response are generally very high, sometimes bordering on levels that will result in toxicity to the test animals. The present study was designed to test the hypothesis that low doses of two or more agents may be just a...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(88)90066-3
更新日期：1988-04-01 00:00:00
abstract：:A direct relationship exists between aging and increasing incidences of chronic diseases. In fact, with most age-associated diseases individuals manifest an underlying chronic inflammatory state as evidenced by local infiltration of inflammatory cells, such as macrophages, and higher circulatory levels of pro-inflamma...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2005.04.009
更新日期：2006-05-08 00:00:00
abstract：:Loss of heterozygosity (LOH) is an important event of tumorigenesis. In this paper, we report the comprehensive LOH analyses with microsatellite markers and their results at chromosome 8p11.1-q13.3 in gastric cancer. The microsatellite markers D8S2323 and D8S2330 exhibited high LOH frequencies, 54.2 and 57.1%, respect...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2004.03.041
更新日期：2004-09-15 00:00:00
abstract：:The role of reactive oxygen species (ROS) and p38 mitogen-activated protein kinases (MAPK) in tanshinones-induced apoptosis was investigated in HepG2 cells in this study. The major tanshinones (cryptotanshinone, dihydrotanshinone, tanshinone I, tanshinone IIA), isolated from Salvia miltiorrhiza, inhibit cell growth an...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2009.04.040
更新日期：2009-11-18 00:00:00
abstract：:Both insulin-like growth factor II (IGF2) and H19 gene are located on chromosome 11p15.5 in close vicinity to each other, and are imprinted on different parental alleles. Although the exact mechanism remains unclear, loss of imprinting (LOI) leading to the biallelic expression of IGF2 and H19 genes has recently been r...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(97)00279-6
更新日期：1997-11-25 00:00:00
abstract：:The present study was conducted to clarify the mechanism responsible for enhancement of the anti-melanoma activity of levodopa methylester by supplemental ascorbate in vivo. 5-Hydroxydopa, a known cytotoxic agent and the major metabolite formed from levodopa in the presence of ascorbate and mushroom tyrosinase in vitr...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(85)90154-5
更新日期：1985-11-01 00:00:00
abstract：:Survivin, a novel antiapoptosis gene, was identified as a member of the inhibitor of apoptosis protein (IAP) family. Unique among IAP, survivin has been found to be abundantly expressed in a wide variety of human malignancies, whereas it is undetectable in normal adult tissues. Recently, three splicing variants of sur...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2003.12.020
更新日期：2004-12-28 00:00:00
abstract：:Dysregulation of circular RNA Foxo3 (circFoxo3) has been reported to be involved in breast cancer and non-small lung cancer progression. However, little is known about the role of circFoxo3 in prostate cancer, which the present study seeks to investigate. CircFoxo3 expression was analyzed in 22 low-grade prostate canc...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2019.10.006
更新日期：2020-01-01 00:00:00
abstract：:Potential interaction of Aurora-A amplification and BRCA2 mutation was examined in breast tumours from BRCA2 999del5 mutation carriers (n=20) and non-carriers (n=41). Aurora-A amplification studied by FISH was significantly more common in breast tumours from BRCA2 mutation carriers (p=0.0005). Extensive Aurora-A ampli...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2006.06.003
更新日期：2007-04-08 00:00:00
abstract：:Human microsomal epoxide hydrolase (mEH) catalyzes a key step in the biotransformation of benzo[a]pyrene that yields the highly mutagenic (+)-anti-7,8-diol-9,10 epoxide (BPDE). Two polymorphisms have been described in the coding region of the mEH gene (EPHX1) that produce two protein variants: 113Tyr-->113His (exon 3)...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(01)00626-7
更新日期：2001-11-28 00:00:00
abstract：:We have previously shown that oligonucleotides designed to bind in triplex fashion to a specific p53 binding site homology inhibit the proliferation of colon cancer cells in vitro. The present study was designed to extend these observations in an in vivo model. HCT 116 human colon carcinoma cells were injected subcuta...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2004.02.002
更新日期：2004-06-08 00:00:00
