Cancer-associated fibroblasts-derived IL-8 mediates resistance to cisplatin in human gastric cancer.

abstract：:Carbaryl (1-naphthyl methyl carbamate: C12H11NO2) CAS Reg. No. 63-25-2) is a widely used broad spectrum carbamate insecticide known to exert various toxic effects on experimental animals. Along with various other toxicological effects carbaryl is reported to increase the incidence of neoplasm in various tissues in rat...

journal_title：Cancer letters

authors： Shukla Y,Antony M,Mehrotra NK

更新日期：1992-02-29 00:00:00

abstract：:The chemopreventive influence of phenethyl isothiocyanate (PEITC) during the post-initiation stage was investigated in the N-nitrosobis(2-oxopropyl)amine (BOP)-initiated hamster tumorigenesis model. A total of 120 female 5-week-old hamsters were divided into six groups. Animals in groups 1-3, each consisting of 30 ham...

journal_title：Cancer letters

authors： Nishikawa A,Furukawa F,Kasahara K,Tanakamaru Z,Miyauchi M,Nakamura H,Ikeda T,Imazawa T,Hirose M

更新日期：1999-07-01 00:00:00

abstract：:The expression of the WAF1/CIP1 gene product, p21, in enzyme-altered foci (EAF) induced by diethylnitrosamine (DEN) and phenobarbital (PB) was examined. p21 expression in the nucleus of hepatocytes in EAF was decreased compared to surrounding tissue. Fifty-eight percent of all GST-P-positive EAF induced by DEN and 79%...

journal_title：Cancer letters

authors： Martens U,Lennartsson P,Högberg J,Stenius U

更新日期：1996-06-24 00:00:00

abstract：:Immune checkpoint blockade (ICB) has revolutionised the treatment of solid tumours, yet most patients do not derive a clinical benefit. Resistance to ICB is often contingent on the tumour microenvironment (TME) and modulating aspects of this immunosuppressive milieu is a goal of combination treatment approaches. Radia...

journal_title：Cancer letters

authors： Donlon NE,Power R,Hayes C,Reynolds JV,Lysaght J

更新日期：2021-01-12 00:00:00

abstract：:The effects of different sources of dietary protein, fat and carbohydrate on tumor development and on tests relating to cell-mediated immunity were investigated in male BALB/c mice after subcutaneous injection of 8 X 10(4) 1,2-dimethylhydrazine (DMH)-induced colon tumor (no. 51) cells. Results indicated that mice fed ...

journal_title：Cancer letters

authors： Nutter RL,Gridley DS,Kettering JD,Andres ML,Aprecio RM,Slater JM

更新日期：1983-02-01 00:00:00

abstract：:Peroxiredoxin I (Prx I) is newly discovered oxidative stress inducible protein, having a thioredoxin peroxidase activity. The Prx I expression level in 107 samples out of 60 thyroid lesions, including normal thyroid, tumors and thyroiditis including Graves' disease were examined using immunoblotting. Prx I expression ...

journal_title：Cancer letters

authors： Yanagawa T,Ishikawa T,Ishii T,Tabuchi K,Iwasa S,Bannai S,Omura K,Suzuki H,Yoshida H

更新日期：1999-10-18 00:00:00

abstract：:Previous work by others shows that d-limonene (LIM) inhibits carcinogen-induced lung tumorigenesis in mice and strongly suggests that LIM can inhibit the metabolic activation of nitrosamines such as 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Thus, in the current study, the ability of LIM and other monoterpe...

journal_title：Cancer letters

authors： Morse MA,Toburen AL

更新日期：1996-07-12 00:00:00

abstract：:Hypusine formation on the eukaryotic initiation factor 5A (eIF-5A) precursor is ubiquitously present in eukaryotic cells and archebacteria. In this reaction, deoxyhypusine synthase catalyzes the conversion of one unique lysine residue on eIF-5A to deoxyhypusine using spermidine as the substrate. Hydroxylation of the d...

journal_title：Cancer letters

authors： Chen ZP,Chen KY

更新日期：1997-05-19 00:00:00

abstract：:The mammary carcinogenicity of two diol epoxide metabolites of the commonly occurring environmental carcinogen benzo[j]fluoranthene (BjF) was investigated by direct application to the tissue beneath the mammary glands of female CD rats. The compounds tested were trans-4,5-dihydroxy-anti-6,6a.epoxy-4,5,6,6a-tetrahydroB...

journal_title：Cancer letters

authors： Hecht SS,Rivenson A,Amin S,Krzeminski J,el-Bayoumy K,Reddy BS,Kurtzke C,La Voie EJ

更新日期：1996-09-10 00:00:00

abstract：:We have successfully generated cytotoxic monoclonal antibodies against a rat histiocytoma, AK-5. Monoclonal antibodies obtained after fusing immunized rat splenocytes with SP2/0 myeloma, were cytotoxic to AK-5 cells in the presence of complement. These monoclonals were highly specific and did not show any cross reacti...

journal_title：Cancer letters

authors： Khar A,Varalakshmi C,Pardhasaradhi BV,Ali AM

更新日期：1992-06-15 00:00:00

abstract：:Breast fluid which bathes the mammary ductal epithelium may contain tumorogenic components. In view of the number of tobacco components inhaled during smoking, it was of interest whether nicotine and its metabolites were present in this fluid. Fluid was obtained from the nipple from menstruating women who were smokers...

journal_title：Cancer letters

authors： Hill P,Wynder EL

更新日期：1979-04-01 00:00:00

abstract：:Cellular phosphoprotein profiles from normal mouse embryonic fibroblast AKR-2B cells were compared to those of their permanently, chemically transformed malignant counterparts AKR-MCA cells, and AKR-2B cells reversibly transformed by transforming growth factor (AKR-TGF). Similar 32P-phosphorylation profiles were obser...

journal_title：Cancer letters

authors： Chakrabarty S,Brattain MG

更新日期：1985-11-01 00:00:00

abstract：:We investigated the effects of the ethyl acetate extract of grapefruit juice (GFJ), that of orange juice (OJ) and their components on the uptake of [(3)H]vincristine into adriamycin-resistant human myelogenous leukemia cells. Its uptake was increased by the extracts of GFJ and OJ up to 7- and 3-fold, respectively, as ...

journal_title：Cancer letters

authors： Ikegawa T,Ushigome F,Koyabu N,Morimoto S,Shoyama Y,Naito M,Tsuruo T,Ohtani H,Sawada Y

更新日期：2000-11-10 00:00:00

abstract：:The RB-E2F1 pathway is an important mechanism of cell-cycle control, and deregulation of this pathway is one of the key factors contributing to tumorigenesis. Cyclin-dependent kinases (CDKs) and Cyclin D have been known to increase in aggressive thyroid cancer. However, there has been no study to investigate effects o...

journal_title：Cancer letters

authors： Lee HJ,Lee WK,Kang CW,Ku CR,Cho YH,Lee EJ

更新日期：2018-03-28 00:00:00

abstract：:Effect of CF(3)-STLC, a potent kinesin spindle protein (KSP) inhibitor, on K562 human CML cell line was investigated. Treatment with CF(3)-STLC induced mitotic arrest of the cell cycle with the appearance of characteristic monoastral spindles, subsequent apoptotic cell death and cleavage of PARP-1, caspase-3, and 4E-B...

journal_title：Cancer letters

authors： Shimizu M,Ishii H,Ogo N,Unno Y,Matsuno K,Sawada J,Akiyama Y,Asai A

更新日期：2010-12-01 00:00:00

abstract：:Suicide gene therapy could be an attractive addition to the treatment of ovarian carcinomas, for which acquired chemoresistance frequently results in treatment failure. Here we show that transfection of the HSV-tk gene, followed by incubation with up to 1 mM ganciclovir fails to induce cell death in SKOV3 chemoresista...

journal_title：Cancer letters

authors： Ziller C,Lincet H,Muller CD,Staedel C,Behr JP,Poulain L

更新日期：2004-08-20 00:00:00

abstract：:EGF-receptor family members (EGFRs) as well as c-Src are over expressed in approximately 70% of breast cancer, and in most of the tumors c-Src is co-over expressed with at least one of the EGFRs, suggesting that they may interact functionally and play a role in the development and progression of the malignancy. We hyp...

journal_title：Cancer letters

authors： Nautiyal J,Majumder P,Patel BB,Lee FY,Majumdar AP

更新日期：2009-10-08 00:00:00

abstract：:Oral squamous cell carcinoma (OSCC) is associated with a high potential of tumor recurrence and metastasis, leading to poor prognosis. Cell motility is an important factor in the progression and metastasis of cancers. Recently, Fascin has been linked to tumor progression by induction of cell motility. However, the pre...

journal_title：Cancer letters

authors： Lee TK,Poon RT,Man K,Guan XY,Ma S,Liu XB,Myers JN,Yuen AP

更新日期：2007-09-08 00:00:00

abstract：:Liver microsomes from control and treated rats (P4501A, 2B, 2E1-induced) metabolize at variable metabolic rates eight N-nitroso-di-n-alkylamines, including five symmetrical (N-nitroso-dimethyl, -diethyl, -dipropyl, -dibutyl and -diamyl-amines) and four asymmetrical (N-nitrosomethylethyl, methylpropyl, methylbutyl, and...

journal_title：Cancer letters

authors： Bellec G,Goasduff T,Dreano Y,Menez JF,Berthou F

更新日期：1996-02-27 00:00:00

abstract：:Fanconi Anemia has recently been associated with a high risk of head and neck squamous cell carcinoma (HNSCC). Inactivation of the Fanconi Anemia (FANC-BRCA) pathway via promoter methylation of the FANCF gene has been proposed to be responsible for variation in cisplatinum (CDDP) sensitivity seen in ovarian and HNSCCs...

journal_title：Cancer letters

authors： Snyder ER,Ricker JL,Chen Z,Waes CV

更新日期：2007-01-08 00:00:00

abstract：:In order to adapt to the reduced availability of nutrients and oxygen in the tumor microenvironment and the increased requirements of energy and building blocks necessary for maintaining their high proliferation rate, malignant cells undergo metabolic changes that result in an increased production of lactate, nitric o...

journal_title：Cancer letters

authors： Netea-Maier RT,Smit JWA,Netea MG

更新日期：2018-01-28 00:00:00

abstract：:First-generation EGFR tyrosine kinase inhibitors (TKIs) such as erlotinib have significant activity in NSCLC patients with activating EGFR mutations. However, EGFR-TKI resistance inevitably occurs after approximately 12 months of treatment. Acquired mechanisms of resistance, other than secondary mutations in EGFR (T79...

journal_title：Cancer letters

authors： Chen C,Liu WR,Zhang B,Zhang LM,Li CG,Liu C,Zhang H,Huo YS,Ma YC,Tian PF,Qi Q,Li JJ,Tang Z,Zhang ZF,Giaccone G,Yue DS,Wang CL

更新日期：2020-08-28 00:00:00

abstract：:Inhibition of angiogenesis provides a potential anti-cancer therapy. Here we describe a novel recombinant peptide composed of active fragments of two distinct angiogenesis inhibitors, platelet factor-4 (C-13 fragment) and vasostatin (N-terminal amino acids 135-164) with a nonpolar peptide bridge of Gly-Pro-Gly. This f...

journal_title：Cancer letters

authors： Li X,Jiang L,Wang Y,Xiao Y,Huang Y,Yao Q,Yang Y,Wu X

更新日期：2007-10-18 00:00:00

abstract：:The malignant phenotype results from multiple genetic alterations, including the activation of oncogenes and inactivation of tumor suppressor genes. Activation of the Ki-ras oncogene has been implicated as an early event in the pathogenesis of lung adenocarcinomas in humans and experimental animal models. Previous stu...

journal_title：Cancer letters

authors： Mizesko MC,Grewe C,Grabner A,Miller MS

更新日期：2001-10-22 00:00:00

abstract：:Though significant progress has been made in the availability of diagnostic techniques and treatment strategies, pancreatic cancer remains a disease of high mortality rates. Therefore, there is an urgent need for a better understanding of the molecular mechanisms that governs the oncogenesis and metastasis process of ...

journal_title：Cancer letters

authors： Liang C,Qin Y,Zhang B,Ji S,Shi S,Xu W,Liu J,Xiang J,Liang D,Hu Q,Ni Q,Yu X,Xu J

更新日期：2017-03-01 00:00:00

abstract：:Iron-enriched diets caused an increase of tumor rate in two models of dimethylhydrazine(DMH)-induced colon tumorigenesis in mice. The effect was independent of the time the iron-diet was fed, i.e. during DMH-treatment or following the DMH-treatment period. The increase of tumor rate depended on the iron concentration ...

journal_title：Cancer letters

authors： Siegers CP,Bumann D,Trepkau HD,Schadwinkel B,Baretton G

更新日期：1992-08-31 00:00:00

abstract：:Protein kinase C epsilon (PKCε), a member of the novel PKC family, is known to be a transforming oncogene and tumor biomarker for many human solid cancers including renal cell carcinoma (RCC). We isolated side population (SP) cells from the RCC 769P cell line, and proved that those cells possess cancer stem cell (CSC)...

journal_title：Cancer letters

authors： Huang B,Fu SJ,Fan WZ,Wang ZH,Chen ZB,Guo SJ,Chen JX,Qiu SP

更新日期：2016-06-28 00:00:00

abstract：:Osteosarcoma (OS) is the most frequent paediatric bone cancer, responsible for 9% of all cancer-related deaths in children. In this paper, a new strategy based on delivering edelfosine (ET) in lipid nanoparticles (LN) was explored in order to target the primary tumour and eliminate metastases. The in vitro and in vivo...

journal_title：Cancer letters

authors： González-Fernández Y,Brown HK,Patiño-García A,Heymann D,Blanco-Prieto MJ

更新日期：2018-08-28 00:00:00

abstract：:Not-targeted effects represent a paradigm shift from the "DNA centric" view that ionizing radiation only elicits biological effects and subsequent health consequences as a result of an energy deposition event in the cell nucleus. While this is likely true at higher radiation doses (>1 Gy), at low doses (<100 mGy) non-...

journal_title：Cancer letters

authors： Morgan WF,Sowa MB

更新日期：2015-01-01 00:00:00

abstract：:Bacteria are always a considerable tool for the cancer therapy. The bacteria-derived minicells are re-emerged as a promising drug delivery system for cancer therapy. The minicells are nano-sized, anucleated, non-dividing, and metabolically active cells produced by abnormal bacterial cell division that are able to tran...

journal_title：Cancer letters

authors： Ali MK,Liu Q,Liang K,Li P,Kong Q

更新日期：2020-10-28 00:00:00