Abstract:
:Iron-enriched diets caused an increase of tumor rate in two models of dimethylhydrazine(DMH)-induced colon tumorigenesis in mice. The effect was independent of the time the iron-diet was fed, i.e. during DMH-treatment or following the DMH-treatment period. The increase of tumor rate depended on the iron concentration in the diet (0.5-3.5%). The concentration-dependent iron accumulation in the colonic mucosa of mice was paralleled by increments of malonaldehyde contents indicating lipid peroxidation, another factor known to be involved in tumor development. It is suggested that iron exerts cocarcinogenic activity in the DMH-model by stimulating cell proliferation and inducing oxidative stress in the colonic mucosa. This effect of iron is independent of the time of tumor-initiation by DMH, as it is also observed in the period of tumor-promotion/progression after DMH-treatment.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Siegers CP,Bumann D,Trepkau HD,Schadwinkel B,Baretton Gdoi
10.1016/0304-3835(92)90239-rkeywords:
subject
Has Abstractpub_date
1992-08-31 00:00:00pages
245-9issue
3eissn
0304-3835issn
1872-7980pii
0304-3835(92)90239-Rjournal_volume
65pub_type
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