Abstract:
:The expression of the WAF1/CIP1 gene product, p21, in enzyme-altered foci (EAF) induced by diethylnitrosamine (DEN) and phenobarbital (PB) was examined. p21 expression in the nucleus of hepatocytes in EAF was decreased compared to surrounding tissue. Fifty-eight percent of all GST-P-positive EAF induced by DEN and 79% of the EAF induced by PB were p21-negative. The proportion of p21-negative EAF increased with the size of the foci and more than 90% of the largest EAF were p21-negative. p21 is a mediator of p53 signals leading to block of the cell cycle. In conjunction with previous data indicating that p53 is not induced in GST-P-positive hepatocytes isolated from EAF-bearing rats, the results of this study suggest a role for altered signaling in the G1-S check point in rat hepatocarcinogenesis.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Martens U,Lennartsson P,Högberg J,Stenius Udoi
10.1016/0304-3835(96)04218-8subject
Has Abstractpub_date
1996-06-24 00:00:00pages
21-6issue
1eissn
0304-3835issn
1872-7980pii
0304383596042188journal_volume
104pub_type
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