Abstract:
:The rate and extent of metastasis by prostate adenocarcinoma-III cells was enhanced in Lobund-Wistar rats by administration of immune-suppressive cyclosporine A. PA-III cells spread from the subcutaneous PA-III-derived tumor, through ipsilateral lymph nodes, to the lungs in which they developed secondary tumors. Swollen lymph nodes, compacted with PA-III cells, indicate that the 'normal' host-engendered level of intravascular non-specific restraints to metastasis were abrogated by CSA.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Pollard Mdoi
10.1016/s0304-3835(96)04538-7subject
Has Abstractpub_date
1997-01-01 00:00:00pages
221-4issue
1-2eissn
0304-3835issn
1872-7980pii
S0304-3835(96)04538-7journal_volume
111pub_type
杂志文章相关文献
CANCER LETTERS文献大全abstract::Tumor cells need to attain anoikis resistance to survive prior to metastasis making it a vital trait of malignancy. The molecular mechanism by which hepatocellular carcinoma (HCC) cells resist anoikis remains not fully understood. Here, we report that ZNF32 expression is markedly upregulated in HCC cells upon detachme...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2018.09.033
更新日期:2019-02-01 00:00:00
abstract::Two hepatoma cell lines were incubated for 72 h with ATRA and its analog 13cisRA and according to MTT assay, Hep3B cells were highly susceptible whereas HepG2 cells were more resistant to the treatment. At the high concentration of 166 microM, retinoids were able to induce apoptosis in both cell lines and the highest ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2005.06.047
更新日期:2005-11-18 00:00:00
abstract::In this study, we demonstrated that thrombin activates protein kinase C (PKC), mitogen activated protein kinases (MAP kinases), transcription factor nuclear factor-kappa B (NF-kappa B), and cAMP-dependent protein kinase (PKA) in the human renal carcinoma cell line A-498. In addition, it enhanced the migratory capacity...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(01)00870-9
更新日期:2002-06-28 00:00:00
abstract:AIM:To estimate the incidence and latency of Vaginal Intraepithelial Neoplasia (VAIN) in women previously hysterectomized for benign/malign pathology and to evaluate the role of high risk HPVs in the prediction of persistent or recurrent disease. SUBJECTS AND METHODS:830 women with prior hysterectomy for benign/malign...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2006.09.003
更新日期:2007-05-08 00:00:00
abstract::The chemokine CXCL12 (SDF-1) and its receptor, CXCR4, have been implicated in organ-specific metastases of several malignancies. Head and neck squamous cell carcinoma (HNSCC) predominantly metastasizes to lymph nodes, and recent evidence has shown that CXCL12 stimulates HNSCC migration. We explored the potential role ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2004.04.035
更新日期:2004-10-28 00:00:00
abstract::One of the frontiers in cancer personalized-medicine aims at glycosylation. Cells are covered with a dense sugar coat of glycolipids, glycoproteins and free glycans. In cancer, the characteristic cell surface glycosylation is frequently transformed due to altered expression of glycan-modifying enzymes. This often lead...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2013.10.005
更新日期:2014-09-28 00:00:00
abstract::Current limitation in cancer genomic studies is a lack of the integration of various omics data generated through next generation sequencing technologies, as well as a lack of the sounding and comprehensive epigenomic and genomic information about a particular cancer cell type. In this review, we will discuss main asp...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2012.11.033
更新日期:2013-11-01 00:00:00
abstract::We investigated the relationship between ErbB-2 and HLA in order to clarify the clinical and genetic factors related to Japanese patients with lung cancer. Thirty-nine of the 73 lung cancer patients (53.4%) had elevated levels of ErbB-2. Only seven of 23 (30. 4%) patients with small cell carcinoma had elevated ErbB-2 ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(99)00437-1
更新日期:2000-04-28 00:00:00
abstract::The etiology of prostatic adenocarcinoma remains unclear. Prostate cancer cells of varying metastatic potential and apoptotic resistance show altered expression of plasma membrane ion channels and unbalanced Ca2+ homeostasis. Ca(2+)-activated Cl(-) channels (CaCCs) are robustly expressed in epithelial cells and functi...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2012.07.015
更新日期:2012-12-29 00:00:00
abstract::In the present study, Tbx3, a member of the T-box family of transcription factors, was identified as an up-regulated gene by mRNA differential display in the regression (apoptosis) stage after uracil-induction of papillomatosis in the rat urinary bladder. Immunohistochemical analysis revealed that apoptosis cells are ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2004.07.051
更新日期:2005-02-28 00:00:00
abstract::Diabetes mellitus type II (DM) and immune cell infiltration determine patient outcome in many tumor entities. Here we studied a possible link between the metabolic and immune cell status of OSCC patients. Glucose transporter (GLUT) 1 mRNA expression was elevated in all tumor samples, whereas other glycolytic markers s...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2020.11.029
更新日期:2021-02-28 00:00:00
abstract::By comparing protein profiles of nasopharyngeal carcinoma HONE1 cells to transformed nasopharyngeal epithelial NP 69 cells, several clusters of differentially expressed proteins were identified. The increased expression of cytokeratin 8 (CK8) and pyruvate kinase M2 was a common feature in four NPC cell lines compared ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2008.02.015
更新日期:2008-07-08 00:00:00
abstract::This study investigated the role of miR-206 in estrogen receptor-α (ERα)-positive endometrial endometrioid adenocarcinoma (EEC). We profiled miR-206 expression in 30 EEC clinical samples using qRT-PCR, and explored its relationship with ERα and clinical parameters. A luciferase reporter assay assessed the ERα targetin...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2011.09.014
更新日期:2012-01-01 00:00:00
abstract::Human cytolytic fusion proteins (hCFPs) offer a promising immunotherapeutic approach for the treatment of solid tumors, avoiding the immunogenicity and undesirable side-effects caused by immunotoxins derived from plants or bacteria. The well-characterized human serine protease granzyme B has already been used as a the...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.02.020
更新日期:2016-05-01 00:00:00
abstract::6-(1-Hydroxyimino-4-methylpentyl)5,8-dimethyoxy 1,4-naphthoquinone S-52 (DMNQ S-52) was reported to have cytotoxic activity against L1210 leukemia cells. In the present study, we investigated the apoptotic mechanism of DMNQ S-52 in vitro and in vivo in murine solid cancer cells. DMNQ S-52 exerted cytotoxicity against ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2005.02.042
更新日期:2006-02-20 00:00:00
abstract::The comparative effects of the subchronic administration to rats of ethionine-supplemented and of chemically defined methyl-deficient diets on the hepatic levels of S-adenosylmethionine (SAM) and of ornithine decarboxylase (ODC), an enzyme marker of cell proliferation, were studied. Both treatments led to decreased he...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(81)90018-5
更新日期:1981-08-01 00:00:00
abstract::Patients (459) with chronic gastritis, ulcers, polyposis and different types of gastric cancers were examined by endoscopic fluorescent technique using a special drug based on the sodium salt of fluorescein (F1). Eighty-five percent of gastric cancers showed positive fluorescence. The F1 distribution in the stomach of...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(93)90163-4
更新日期:1993-04-30 00:00:00
abstract::Up to a 50% rate of thyroid gland tumours was induced in Sprague-Dawley rats after s.c. administration of di-isopropanolnitrosamine (DIPN). The neoplasms occurred both unilaterally and bilaterally, and were identified histologically as adenomas and adenocarcinomas of follicular epithelium origin. In a few instances, a...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(77)80022-0
更新日期:1977-03-01 00:00:00
abstract::The ability of the cytosolic arylamine oxidase to convert structurally diverse aromatic and heterocyclic amines to mutagens in the Ames test was investigated using hepatic cytosol from Aroclor 1254-treated rats as the activation system. Using this system, only amino compounds containing at least three fused aromatic r...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(98)00037-8
更新日期:1998-05-15 00:00:00
abstract::Although it is well known that ovarian endometriosis occasionally gives rise to ovarian cancers with specific histology such as endometrioid and clear cell carcinomas, its etiology is not fully understood. We have shown that a stressful microenvironment within the endometriotic cyst may lead to cancer development by i...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2011.06.039
更新日期:2011-11-28 00:00:00
abstract::Increased intramedullary apoptotic death of hematopoietic cells is thought to contribute to the ineffective hematopoiesis in myelodysplastic syndromes (MDS). Furthermore, high amounts of tumor necrosis factor alpha (TNF alpha) have previously been correlated with apoptosis in MDS marrows. The present studies were unde...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(99)00072-5
更新日期:1999-06-01 00:00:00
abstract::The aim of this study was to investigate the interaction of tamoxifen (TAM) with the so-called Type II estrogen binding sites (Type II EBS) in both the cytosolic and the nuclear fraction of the ER-negative A 2780 human ovarian cancer cell line and in an ER-negative ovarian cancer tissue. Although cytosolic and nuclear...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(95)03922-j
更新日期:1995-09-04 00:00:00
abstract::Fanconi anemia (FA) is a rare genome instability syndrome characterized by progressive bone marrow failure and predisposition to cancer, especially head and neck squamous cell carcinoma. Surgical resection is the standard of care for solid tumors, as patients with FA do not tolerate genotoxic chemotherapies or radiati...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2019.12.008
更新日期:2020-03-01 00:00:00
abstract::We conducted a pilot study to assess the feasibility using the Electoral Register to carry out a cervical cancer screening programme on a Health District basis. A random sample of 500 names and addresses were drawn from a computerised list of the Electoral Register from three Electoral Wards in Oxford. A pilot study s...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(85)90039-4
更新日期:1985-09-30 00:00:00
abstract::Since CP always exists in aqueous solution as a mixture of native drug and various aqua and hydroxo species, it is conceivable that one or more of these aquated species is the main form of the drug that enters the cell. To test this hypothesis, we examined the accumulation by 2008 human ovarian carcinoma cells of CP a...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(94)90205-4
更新日期:1994-06-30 00:00:00
abstract::Cucurbitacin B (CuB), has recently emerged as a potent anticancer agent; however, its efficacy in non-small-cell lung cancer (NSCLC) and the mechanism(s) initiating its biological effects remain largely unclear. In this study, CuB potently suppressed the growth of four NSCLC cells (H1299, A549, HCC-827 and H661) in vi...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2013.01.008
更新日期:2013-05-10 00:00:00
abstract::Starvation-induced hypoglycaemia and streptozotocin-induced diabetes suppressed the growth of Ehrlich ascites tumor in mice. The suppression of tumor growth by diabetes was alleviated by administration of insulin. The number of glucose carriers on tumour cells was found to be reduced in diabetes and partial resumption...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(85)90035-7
更新日期:1985-09-30 00:00:00
abstract::In the course of screening for a novel inhibitor of cyclin-dependent kinase (CDK), HY52 (C17H30O2N2; molecular weight 294) was isolated from the leaves of Pata de Vaca (Bauhinia forficata). The growth of HeLa cells was inhibited in a dose-dependent manner when treated with 0.07 to 0.41 mM of HY52 for 24 h (IC50:0.11 m...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2005.03.002
更新日期:2006-02-20 00:00:00
abstract:BACKGROUND:This study characterizes the second hit spectrum in BRCA1 and BRCA2-associated breast and ovarian cancers at both gene loci to investigate if second hit mechanisms are mutually exclusive or able to coincide within the same tumor. METHODS:Loss of heterozygosity, somatic point mutations and copy number altera...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2018.03.026
更新日期:2018-07-01 00:00:00
abstract::Diet is one of the elements that may influence the development of lung cancer. To ascertain the relationship between meat and fish consumption and the appearance of this disease, a case-control study was conducted on a population in Galicia (NW Spain), with a sample of 295 cases and 322 controls. All cases had histolo...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2006.12.008
更新日期:2007-07-08 00:00:00