Abstract:
:Tumor cells need to attain anoikis resistance to survive prior to metastasis making it a vital trait of malignancy. The molecular mechanism by which hepatocellular carcinoma (HCC) cells resist anoikis remains not fully understood. Here, we report that ZNF32 expression is markedly upregulated in HCC cells upon detachment. Enforced ZNF32 expression significantly promotes the anchorage-independent growth capability of HepG2 and Huh7 cells, whereas knockdown of ZNF32 results in increased apoptosis of HCC cells after detachment. Mechanistically, we demonstrate that ZNF32 overexpression suppresses the reactive oxygen species (ROS) accumulation and maintains mitochondrial membrane potential, leading to ATP, GSH and NADPH elevation and promoting HCC cell survival in response to suspension. Moreover, ZNF32 enhances the phosphorylation and activation of Src/FAK signaling. Src and FAK inhibitors effectively reverse ZNF32-induced anoikis resistance in HCC cells. Collectively, our findings not only reveal a novel and important mechanism by which ZNF32 contributes to anoikis resistance through maintaining redox homeostasis and activating Src/FAK signaling, but also suggest the potential therapeutic value of ZNF32 in HCC patients.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Li K,Zhao G,Ao J,Gong D,Zhang J,Chen Y,Li J,Huang L,Xiang R,Hu J,Lin P,Wei Ydoi
10.1016/j.canlet.2018.09.033subject
Has Abstractpub_date
2019-02-01 00:00:00pages
271-278eissn
0304-3835issn
1872-7980pii
S0304-3835(18)30669-4journal_volume
442pub_type
杂志文章相关文献
CANCER LETTERS文献大全abstract::The identification of frameshift mutations in the coding region of the bax gene in Western cases of hereditary non-polyposis colorectal cancer provided evidence that the disease could be caused by the disruption of a tumor suppressor gene associated with microsatellite instability. In order to determine whether this o...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(97)00477-1
更新日期:1998-02-27 00:00:00
abstract::We have previously shown that transforming growth factor (TGF)-beta up-regulates matrix metalloproteinase (MMP)-2 leading to the induction of oncogenic signaling in preneoplastic MCF10A human breast epithelial cells. The present study investigated the mechanism of transcriptional regulation of MMP-2 by TGF-beta in MCF...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2006.12.016
更新日期:2007-07-08 00:00:00
abstract::Inhibition of angiogenesis provides a potential anti-cancer therapy. Here we describe a novel recombinant peptide composed of active fragments of two distinct angiogenesis inhibitors, platelet factor-4 (C-13 fragment) and vasostatin (N-terminal amino acids 135-164) with a nonpolar peptide bridge of Gly-Pro-Gly. This f...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2007.05.002
更新日期:2007-10-18 00:00:00
abstract::We investigated the anticancer activity of erufosine in oral squamous carcinoma cell lines in terms of cell proliferation, colony formation, induction of autophagy/apoptosis, cell cycle and mTOR signaling pathway. Erufosine showed dose-dependent cytotoxicity in all cell lines, it induced autophagy as well as apoptosis...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2011.12.032
更新日期:2012-06-01 00:00:00
abstract::The effect of interferon (IFN)-alpha, beta and gamma on the growth of DHL-4 diffuse large B cell lymphoma cells was studied. IFN-beta significantly inhibited the cell growth, and the effect was stronger than that of IFN-alpha. IFN-gamma did not inhibit the cell growth because of lack of IFN-gamma receptors. IFN-beta c...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2004.11.054
更新日期:2005-07-08 00:00:00
abstract::We planned to determine the relationship between angiogenesis and p53 mutational status in advanced-stage epithelial ovarian cancer. Using 190 tumor samples from patients with stage III and IV ovarian cancer we performed p53 sequencing, immunohistochemistry, and CD31 microvessel density (MVD) determination. MVD was el...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2012.12.016
更新日期:2013-04-30 00:00:00
abstract::Medroxyprogesterone acetate (MPA) is currently used therapeutically in the treatment of mammary and endometrial carcinomas. In order to develop a more potent and useful drug, we synthesized the novel compound, 9alpha-fluoromedoroxyprogesterone acetate (FMPA), by fluorinating MPA, and we also previously reported that F...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(00)00375-x
更新日期:2000-06-01 00:00:00
abstract::Though many investigators have reported relationships between the CCND1 polymorphism and susceptibility to various carcinomas, to our knowledge, no report has been issued concerning its relationship with uterine cervical cancer. Thus, we undertook this study to investigate the association between CCND1 polymorphisms a...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2004.12.024
更新日期:2005-06-08 00:00:00
abstract::Helicobacter pylori (H. pylori) infection is considered a major risk factor for gastric cancer. CagA behaves as a major bacterial oncoprotein playing a key role in H. pylori-induced tumorigenesis. Cancer stem cells (CSCs) are believed to possess the ability to initiate tumorigenesis and promote progression. Although s...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.02.032
更新日期:2016-05-01 00:00:00
abstract::In the present study, the question of whether the ubiquitous environmental pollutant, 1-nitropyrene (1-NP), can induce gamma-glutamyltranspeptidase (GGT)-positive foci, an early lesion occurring during hepatocarcinogenesis, when given orally to F344 rats was examined. Significant induction of GGT-positive foci was obs...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(89)90031-1
更新日期:1989-04-01 00:00:00
abstract::Chlorophyllin (CHL), a water-soluble derivative of chlorophyll, has been used for the treatment of several abnormal human conditions without apparent toxicity. Recent studies have revealed that CHL has the excellent chemopreventive potential. In the present investigation, we have found the inhibitory activities of CHL...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(99)00229-3
更新日期:1999-10-18 00:00:00
abstract::We investigated the influence of TNF-alpha on the metastasis of cancer cells. Treatment of cultured colon 26 cells with TNF-alpha enhanced metastatic properties including production of MMP-9, adhesion, migration and invasion. Cells treated with TNF-alpha in vitro showed marked potential to metastasize to the lung and ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2004.12.027
更新日期:2005-12-08 00:00:00
abstract::In order to characterize the enzymes involved in the purine nucleotide catabolism as indicators of invasiveness and aggressiveness of malignant gliomas, the degradation of extracellular nucleotides by five different glioma cell lines was investigated and compared with primary astrocytes. Rapid hydrolysis of extracellu...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(03)00308-2
更新日期:2003-08-20 00:00:00
abstract::Radiotherapy (RT) is one of the most important strategies in cancer treatment. Radioresistance is a major challenge to RT and results in locoregional recurrence and metastasis. Thus, there is a great interest in investigating biomarkers to distinguish radiosensitive from radioresistant (RR) cancer patients. The develo...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2015.09.013
更新日期:2015-12-28 00:00:00
abstract::Upregulation of serine biosynthesis pathway activity is an increasingly apparent feature of many cancers. Most notably, the first rate-limiting enzyme of the pathway, phosphoglycerate dehydrogenase (PHGDH), is genomically amplified in some melanomas and breast cancers and can be transcriptionally regulated by various ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2020.01.036
更新日期:2020-04-28 00:00:00
abstract::Chronic elevated free fatty (FFA) levels are linked to metabolic disorders and tumorigenesis. However, the molecular mechanism by which FFAs induce cancer remains poorly understood. Here, we show that the tumor suppressor PTEN protein levels were decreased in high fat diet (HFD) fed mice. As palmitic acid (PA, C16:0) ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2020.10.007
更新日期:2021-01-01 00:00:00
abstract::Cancer cells are derived from their precursor cells, which normally develop to the matured cells to form individual organs. Neuroblastoma, one of the most common pediatric solid tumors, originates from possible cancer stem cells derived from the neural crest. During the development, neural crest cells segregate into s...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/S0304-3835(03)00457-9
更新日期:2004-02-20 00:00:00
abstract::The appearance of apoptosis has been used as an index of carcinogen-induced damage incurred by the intestinal epithelium. Here we report that the cytotoxic response elicited by gamma radiation in the duodenal and colonic epithelium of the mouse is markedly affected by the time of day at which the animals are irradiate...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(83)90203-3
更新日期:1983-12-01 00:00:00
abstract::Fibronectin concentration was determined in plasma from 97 patients with benign or malignant breast disease and from 62 controls. Median plasma fibronectin concentration (microgram FN/ml plasma) appeared to be significantly higher in patients with non-metastatic or metastatic breast cancer as compared to age-matched c...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(86)90071-6
更新日期:1986-12-01 00:00:00
abstract::Non-steroidal anti-inflammatory drugs (NSAIDs) are used extensively for analgesic and antipyretic treatments. In addition, NSAIDs reduce the risk and mortality to several cancers. Their mechanisms in anti-tumorigenesis are not fully understood, but both cyclooxygenase (COX)-dependent and -independent pathways play a r...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2014.01.021
更新日期:2014-05-01 00:00:00
abstract::Gene methylation is an important molecular event in prostate carcinogenesis that may have diagnostic and prognostic significance. We evaluated the methylation status of eight genes implicated in prostate carcinogenesis. DNA was extracted from archived paraffin-embedded tumor blocks from 90 prostate cancer patients. Ge...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2003.11.027
更新日期:2004-03-18 00:00:00
abstract::Samples of human endometrial carcinomas of ranging degree of histological differentiation, and normal endometrial tissues were screened for the presence of single site DNA mutations at codon 12 of the C-K-ras gene using oligonucleotide hybridisation of DNA amplified by the polymerase chain reaction (PCR). Two instance...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(90)90223-k
更新日期:1990-05-15 00:00:00
abstract::Two hair dye components, carcinogenic 4-nitro-2-aminophenol and 5-nitro-2-aminophenol, induced Cu(II)-dependent DNA cleavage frequently at thymine and guanine residues in DNA fragments obtained from the c-Ha-ras-1 protooncogene. When the p53 tumor suppressor gene was used, 4-nitro-2-aminophenol caused Cu(II)-dependent...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(97)00533-8
更新日期:1998-04-10 00:00:00
abstract::Effect of CF(3)-STLC, a potent kinesin spindle protein (KSP) inhibitor, on K562 human CML cell line was investigated. Treatment with CF(3)-STLC induced mitotic arrest of the cell cycle with the appearance of characteristic monoastral spindles, subsequent apoptotic cell death and cleavage of PARP-1, caspase-3, and 4E-B...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2010.06.007
更新日期:2010-12-01 00:00:00
abstract::The di-methyl-, di-ethyl-, di-propyl-, di-normal butyl-, and di-iso-butyl-ethers of hematoporphyrin were synthesized and shown to possess chromatographic properties similar to those of the tumorlocalizing components of hematoporphyrin derivative (Hpd). The cellular uptake of these ethers, as well as their retention in...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(87)90178-9
更新日期:1987-03-01 00:00:00
abstract::The significance of altered expression of MN blood group antigens was examined by studies on the expressions of Thomsen-Friedenreich antigen (T antigen) and Tn antigen in primary and metastatic lesions of 29 human uterine cervical cancers. These antigens were measured by the avidin-biotin-peroxidase (ABC) method with ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(93)90239-6
更新日期:1993-11-01 00:00:00
abstract::Fanconi Anemia has recently been associated with a high risk of head and neck squamous cell carcinoma (HNSCC). Inactivation of the Fanconi Anemia (FANC-BRCA) pathway via promoter methylation of the FANCF gene has been proposed to be responsible for variation in cisplatinum (CDDP) sensitivity seen in ovarian and HNSCCs...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2005.12.028
更新日期:2007-01-08 00:00:00
abstract::Very few studies have been reported the function of wild type IDH1 in tumor progress. Previously, we reported that IDH1 correlated with pathological grade and metastatic potential inversely in human osteosarcoma. Here, IDH1 was found lower expressed in osteosarcoma tissues than that of adjacent normal bone tissues. In...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2013.12.020
更新日期:2014-04-28 00:00:00
abstract::Bone metastasis is a major cause of prostate cancer (PCa) mortality. Although docetaxel chemotherapy initially extends patients' survival, in most cases PCa becomes chemoresistant and eventually progresses without a cure. In this study, we developed a novel small-molecule compound BKM1972, which exhibited potent in vi...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2019.01.010
更新日期:2019-04-01 00:00:00
abstract::MUTYH-associated polyposis (MAP) is an autosomal recessive condition predisposing to colorectal cancer, caused by constitutional biallelic mutations in the base excision repair (BER) gene MUTYH. Colorectal tumours from MAP patients display an excess of somatic G>T mutations in the APC and KRAS genes due to defective B...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2008.09.022
更新日期:2009-02-18 00:00:00