DLK1, delta-like 1 homolog (Drosophila), regulates tumor cell differentiation in vivo.

abstract：:The primary aim of this study was to find novel chemopreventive agents effective against breast cancer. Endoplasmic reticulum (ER) stress can induce apoptosis through the unfolded protein response (UPR). 2'-Hydroxy-2,3,5'-trimethoxychalcone (DK143) is a synthetic flavonoid derivative. The present study provides eviden...

journal_title：Cancer letters

authors： Lee DH,Jung Jung Y,Koh D,Lim Y,Lee YH,Shin SY

更新日期：2016-03-01 00:00:00

abstract：:N-[2-(p-bromocinnamylmethylamino) ethyl]-5-isoquinolinesulfonamide (H-87), a newly synthesized inhibitor of protein kinase A, significantly decreased the drug resistance of multidrug resistant human U937/M cells, mouse FM3A/M and P388/M cells. Northern blot analysis showed MDR1 gene expression was decreased in H-87-tr...

journal_title：Cancer letters

authors： Kim SH,Park JI,Chung BS,Kang CD,Hidaka H

更新日期：1993-10-15 00:00:00

abstract：:NF-kappaB is activated in many types of cancer. Phosphorylation of p65 at serine 276 is required for the expression of a subset of NF-kappaB regulated genes, including vascular cell adhesion molecule-1 (VCAM-1) and interleukin-8 (IL-8). Thus, inhibition of serine 276 phosphorylation may prevent metastasis and angiogen...

journal_title：Cancer letters

authors： Law M,Corsino P,Parker NT,Law BK

更新日期：2010-05-28 00:00:00

abstract：:Thioproline (TPRO), an effective nitrite trapping agent in vivo, was examined for its detoxifying ability in rats against N-nitrosodimethylamine (NDMA) and N-nitrosocimetidine (NCIM). When NDMA (37-101.5 mg/kg) was administered with TPRO (532 mg/kg), no influence of TPRO on NDMA-induced lethality and histological resu...

journal_title：Cancer letters

authors： Frank N,Tsuda M,Ohgaki H,Frei E,Kato T,Sato S

更新日期：1990-04-30 00:00:00

abstract：:Gastric cancers with and those without high-frequency microsatellite instability (MSI-H) represent distinctive pathways of carcinogenesis. The aim of this study was to clarify if expression of p53 related genes involved in angiogenesis is differentially regulated between these cancers. We systematically analyzed the e...

journal_title：Cancer letters

authors： Miyamoto N,Yamamoto H,Taniguchi H,Miyamoto C,Oki M,Adachi Y,Imai K,Shinomura Y

更新日期：2007-08-28 00:00:00

abstract：:For biochemical modulation, components of green tea have been shown to be useful modulators in combination with doxorubicin (DOX). We have confirmed that theanine enhances the antitumor activity of DOX due to inhibition of DOX efflux from tumor cells. Because theanine is a glutamate analogue, we found that it is assoc...

journal_title：Cancer letters

authors： Sadzuka Y,Yamashita Y,Sugiyama T,Sonobe T

更新日期：2002-05-28 00:00:00

abstract：:The mucosal glutathione content of the gastrointestinal wall amounted to 50-60% of its concentration in the liver. GSH S-aryltransferase activity (CDNB) was very low in the glandular stomach, colon and rectum amounting to only 5% of liver enzyme activity. There was a marked postpyloric increase in GSH S-aryltransferas...

journal_title：Cancer letters

authors： Siegers CP,Riemann D,Thies E,Younes M

更新日期：1988-05-01 00:00:00

abstract：:The newly identified protein BLAP75/RMI1 associates with the helicase BLM and is critical for the function of the homologous recombination complex. Mutations altering BLM function are associated with highly elevated cancer susceptibility (Bloom's syndrome). We have analyzed the common polymorphism Ser455Asn in RMI1 an...

journal_title：Cancer letters

authors： Broberg K,Höglund M,Gustafsson C,Björk J,Ingvar C,Albin M,Olsson H

更新日期：2007-12-08 00:00:00

abstract：:Telomeres constitute the ends of the linear eukaryotic chromosomes and are essential for the maintenance of chromosome stability and genome integrity. One of the consequences of an altered telomere structure is the formation of telomeric fusions (TFs), that is aberrant chromosomes in which two elements are fused at th...

journal_title：Cancer letters

authors： Rebuzzini P,Lisa A,Giulotto E,Mondello C

更新日期：2004-01-08 00:00:00

abstract：:Considerable evidences have shown that both heat shock transcription factor 1 (HSF1) and autophagy can attenuate the sensitivity of hepatocellular carcinoma (HCC) cells to chemotherapeutic reagents. However, it is still little known whether HSF1 is associated with autophagy in regulating the chemosensitivity of HCC ce...

journal_title：Cancer letters

authors： Zhang N,Wu Y,Lyu X,Li B,Yan X,Xiong H,Li X,Huang G,Zeng Y,Zhang Y,Lian J,Ni Z,He F

更新日期：2017-11-28 00:00:00

abstract：:Vitamin C has been suggested and disputed as an anti-cancer agent. Previous in vitro studies using either primary cell cultures from cancer patients or tumor cell lines have suggested that tumor cells with different lineages may have different sensitivities to ascorbic acid. In this study we report characterization of...

journal_title：Cancer letters

authors： Kao TL,Meyer WJ 3rd,Post JF

更新日期：1993-06-15 00:00:00

abstract：:Liver hyperplasia was induced in rats by daily administration of methylclofenapate (25 mg/kg by gavage). An increase in the incidence of colchicine-arrested metaphases was observed with peaks occurring at 40 h (1.3%), 64 h (6.4%) and 84 h (6.8%) after the start of treatment. This response contrasted with the much larg...

journal_title：Cancer letters

authors： Bybee A,Styles JA,Beck SL,Blackburn D

更新日期：1990-07-16 00:00:00

abstract：:One of the frontiers in cancer personalized-medicine aims at glycosylation. Cells are covered with a dense sugar coat of glycolipids, glycoproteins and free glycans. In cancer, the characteristic cell surface glycosylation is frequently transformed due to altered expression of glycan-modifying enzymes. This often lead...

journal_title：Cancer letters

authors： Padler-Karavani V

更新日期：2014-09-28 00:00:00

abstract：:Expression of the cytoplasmic soluble form of p53 protein in the different rat colon cancer cell lines transfected and non-transfected with Rous sarcoma virus-33 was studied. Concentrations of the p53 protein were detected by commonly used immunochemical methods after its isolation by affinity chromatography columns w...

journal_title：Cancer letters

authors： Sandler B,Grofova M,Smirnoff P,Zusman R,Zusman I

更新日期：1997-12-23 00:00:00

abstract：:Nitrosatability of dried Nigerian vegetables and spices was investigated under simulated gastric conditions. N-Nitroso-dimethylamine (NDMA) was the only volatile nitrosamine found above the preformed level except in ugwu where N-nitroso-piperidine (2.3 ppb) was also detected. The lowest NDMA value of 0.4 ppb was found...

journal_title：Cancer letters

authors： Atawodi SE,Maduagwu EN,Preussmann R,Spiegelhalder B

更新日期：1991-05-24 00:00:00

abstract：:Glioblastoma (GBM) is the most common and aggressive primary brain tumor. Great interest persists in useful therapeutic targets in GBM. Aberrant expression of long non-coding RNAs (lncRNAs) has been functionally associated with many cancers. Here, we elucidated the function and the possible molecular mechanisms of lnc...

journal_title：Cancer letters

authors： Yao Y,Ma J,Xue Y,Wang P,Li Z,Liu J,Chen L,Xi Z,Teng H,Wang Z,Li Z,Liu Y

更新日期：2015-04-01 00:00:00

abstract：:The recurrence rate of soft tissue and bone sarcomas strongly correlates to the status of the surgical margin after excision, yet excessive removal of tissue may lead to distinct, otherwise avoidable morbidity. Therefore, adequate margination of sarcomas both pre- and intra-operatively is a clinical necessity that has...

journal_title：Cancer letters

authors： Baljer BC,Kolhe S,Chan CD,Nicoli F,Ghanbasha A,Brookes MJ,Gamie Z,Ghosh KM,Beckingsale TB,Saleh DB,Ragbir M,Gerrand CH,Jeys L,Knight JC,Petrides G,Rankin KS

更新日期：2020-07-28 00:00:00

abstract：:Hypusine formation on the eukaryotic initiation factor 5A (eIF-5A) precursor is ubiquitously present in eukaryotic cells and archebacteria. In this reaction, deoxyhypusine synthase catalyzes the conversion of one unique lysine residue on eIF-5A to deoxyhypusine using spermidine as the substrate. Hydroxylation of the d...

journal_title：Cancer letters

authors： Chen ZP,Chen KY

更新日期：1997-05-19 00:00:00

abstract：:Spectroscopic techniques have demonstrated that in the microscopically normal mucosa, there is an increase in mucosal micro-circulation in patients harboring neoplasia elsewhere in the colon (i.e. marker of field carcinogenesis). However, the physiological and molecular basis of this early increase in blood supply (EI...

journal_title：Cancer letters

authors： Tiwari AK,Crawford SE,Radosevich A,Wali RK,Stypula Y,Kunte DP,Mutyal N,Ruderman S,Gomes A,Cornwell ML,De La Cruz M,Brasky J,Gibson TP,Backman V,Roy HK

更新日期：2011-07-28 00:00:00

abstract：:A common germline polymorphism of p53 gene produces an Arginine to Proline change at aminoacid position 72. The resulting codon 72 variants have been reported associated with tumor susceptibility since they reduce p53 ability to activate apoptosis. Codon 72 polymorphism may play a role in subside vulnerability to diff...

journal_title：Cancer letters

authors： Granja F,Morari J,Morari EC,Correa LA,Assumpção LV,Ward LS

更新日期：2004-07-16 00:00:00

abstract：:Treatment of HeLa cells with the polyamine biosynthesis inhibitors difluoromethylornithine (DFMO) and/or methylglyoxal bis(guanylhydrazone) (MGBG) results in marked depression in levels of the cellular polyamines putrescine, spermidine and spermine. Cells in this polyamine-depleted state exhibited increased sensitivit...

journal_title：Cancer letters

authors： Snyder RD,Bhatt S

更新日期：1993-08-16 00:00:00

abstract：:The Syrian hamster embryo cell transformation assay has been used to investigate the effect of two synthetic antioxidants on morphological transformation induced by the initiator benzo[a]pyrene (BP). A two-stage protocol was employed with an initiation phase of 2 days and a subsequent promotion phase of 5 days. When 1...

journal_title：Cancer letters

authors： Potenberg J,Schiffmann D,Kahl R,Hildebrandt AG,Henschler D

更新日期：1986-11-01 00:00:00

abstract：:PM2 DNA, forms I and II, were chemically modified with the ultimate carcinogen N-acetoxy-2-acetylaminofluorene. The products were subjected to 3 analytical procedures: (i) buoyant density centrifugation in the presence of the intercalating dyes ethidium bromide or propidium diiodide; (ii) agarose gel electrophoresis: ...

journal_title：Cancer letters

authors： Thielmann HW,Kuhn C

更新日期：1980-02-01 00:00:00

abstract：:We demonstrate herein the ability of transforming growth factor-beta-2 (TGFbeta2) to potently activate extracellular signal-regulated kinase 2 (ERK2) in the highly TGFbeta-sensitive breast cancer cell (BCC) line Hs578T. The ERK2 isoform was activated by 3-fold within 5 min of TGFbeta2 addition to Hs578T cells. However...

journal_title：Cancer letters

authors： Frey RS,Mulder KM

更新日期：1997-07-15 00:00:00

abstract：:Caveolin-1 has been implicated in cellular transformation and tumorigenesis. We assessed lung cancer specimens for caveolin-1 expression immunohistochemistry. A majority of the cell types in the lung and the bronchial epithelium normally exhibited positive staining for caveolin-1. In adenocarcinomas (ADs) of positive ...

journal_title：Cancer letters

authors： Kato T,Miyamoto M,Kato K,Cho Y,Itoh T,Morikawa T,Okushiba S,Kondo S,Ohbuchi T,Katoh H

更新日期：2004-10-08 00:00:00

abstract：:N-α-Acetyltransferase 10 protein (Naa10p) mediates N-terminal acetylation of nascent proteins. Oncogenic or tumor suppressive roles of Naa10p were reported in cancers. Here, we report an oncogenic role of Naa10p in promoting metastasis of osteosarcomas. Higher NAA10 transcripts were observed in metastatic osteosarcoma...

journal_title：Cancer letters

authors： Chien MH,Lee WJ,Yang YC,Tan P,Pan KF,Liu YC,Tsai HC,Hsu CH,Wen YC,Hsiao M,Hua KT

更新日期：2018-10-01 00:00:00

abstract：:We investigated the relationship between ErbB-2 and HLA in order to clarify the clinical and genetic factors related to Japanese patients with lung cancer. Thirty-nine of the 73 lung cancer patients (53.4%) had elevated levels of ErbB-2. Only seven of 23 (30. 4%) patients with small cell carcinoma had elevated ErbB-2 ...

journal_title：Cancer letters

authors： Yoshimura C,Nomura S,Yamaoka M,Ohtani T,Matsuzakiz T,Yamaguchi K,Fukuharal S

更新日期：2000-04-28 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is heterogeneous, rendering its current curative treatments ineffective. The emergence of single-cell genomics represents a powerful strategy in delineating the complex molecular landscapes of cancers. In this study, we demonstrated the feasibility and merit of using single-cell RNA sequ...

journal_title：Cancer letters

authors： Ho DW,Tsui YM,Sze KM,Chan LK,Cheung TT,Lee E,Sham PC,Tsui SK,Lee TK,Ng IO

更新日期：2019-09-10 00:00:00

abstract：:We investigated the anticancer activity of erufosine in oral squamous carcinoma cell lines in terms of cell proliferation, colony formation, induction of autophagy/apoptosis, cell cycle and mTOR signaling pathway. Erufosine showed dose-dependent cytotoxicity in all cell lines, it induced autophagy as well as apoptosis...

journal_title：Cancer letters

authors： Kapoor V,Zaharieva MM,Das SN,Berger MR

更新日期：2012-06-01 00:00:00

abstract：:The AT-rich interaction domain 1A (ARID1A, also known as BAF250a) is a chromatin remodeling gene, which frequently mutates across a broad spectrum of cancers with loss expression of the ARID1A protein. Recently, the association between ARID1A deficiency and immune checkpoint blockade (ICB) therapy has been reported. A...

journal_title：Cancer letters

authors： Hu G,Tu W,Yang L,Peng G,Yang L

更新日期：2020-03-31 00:00:00