Inhibitory effects of monoacylated 2-O-beta-galactosylglycerols on Epstein-Barr virus activation: the significant role of the hexanoyl chain.

abstract：:As a tumor antigen, mesothelin (MSLN) can be identified in various malignancies. MSLN is potential for antigen-specific cancer vaccines. We generated a novel chimeric DNA vaccine using antigen-specific connective tissue growth factor lined with MSLN (CTGF/MSLN). The anti-tumor effects of the CTGF/MSLN DNA vaccine comb...

journal_title：Cancer letters

authors： Chen YL,Chang MC,Chiang YC,Lin HW,Sun NY,Chen CA,Sun WZ,Cheng WF

更新日期：2018-07-01 00:00:00

abstract：:Eight chlorinated ethanes and 3 chlorinated ethylenes were tested in the BALB/c-3T3 cell transformation assay. Under the conditions of the assay, vinyl chloride and 1,1,1-trichloroethane induced a clear positive transformation response while 1,1,2-trichloroethane and trichloroethylene were weakly positive. Chloroethan...

journal_title：Cancer letters

authors： Tu AS,Murray TA,Hatch KM,Sivak A,Milman HA

更新日期：1985-08-01 00:00:00

abstract：:The relationship between the degree of lymphocytic infiltration into the tumor and the prognosis has not been completely evaluated between Epstein-Barr virus (EBV)-positive and -negative gastric carcinoma (GC). Although the average numbers and the grades of the infiltrating CD8+T cells, natural killer cells, dendritic...

journal_title：Cancer letters

authors： Kijima Y,Ishigami S,Hokita S,Koriyama C,Akiba S,Eizuru Y,Aikou T

更新日期：2003-10-08 00:00:00

abstract：:We investigated the molecular mechanisms responsible for fisetin-induced apoptosis in U266 cells. Fisetin elicited the cytotoxicity in U266 cells, manifested as an increased fraction of the cells with sub-G1 content or stained positively with TUNEL labeling. Fisetin enhanced caspase-3 activation, downregulation of Bcl...

journal_title：Cancer letters

authors： Jang KY,Jeong SJ,Kim SH,Jung JH,Kim JH,Koh W,Chen CY,Kim SH

更新日期：2012-06-28 00:00:00

abstract：:The peptide aptamer DUP-1 targets prostate-specific membrane antigen (PSMA)-negative cells, while the RNA aptamer A10-3.2 targets PSMA-positive prostate cancer cells. Moreover, the tumor-suppressor gene phosphatase and tensin homolog (PTEN) and the chemotherapeutic agent doxorubicin (DOX) effectively inhibit prostate ...

journal_title：Cancer letters

authors： Jing P,Cao S,Xiao S,Zhang X,Ke S,Ke F,Yu X,Wang L,Wang S,Luo Y,Zhong Z

更新日期：2016-12-28 00:00:00

abstract：:Fifteen samples from 11 patients suffering from chronic lymphocytic leukaemia (CLL; 5 untreated, 6 chemotherapeutically treated) were analysed for their individual gene expression of the multidrug resistance (MDR) associated genes encoding mdr1/P-glycoprotein, mrp, and topoisomerase II alpha/beta-isoenzymes by a compl...

journal_title：Cancer letters

authors： Beck J,Niethammer D,Gekeler V

更新日期：1994-10-28 00:00:00

abstract：:Comparison of LCC2, the E(2)-independent, tamoxifen-resistant subline of the MCF-7 human breast cancer cell line with its parent line, disclosed that it is more resistant to growth inhibition and apoptosis induction by a variety of agents acting by diverse mechanisms. Thus, LCC2 cells can serve as a useful in-vitro mo...

journal_title：Cancer letters

authors： Lilling G,Hacohen H,Nordenberg J,Livnat T,Rotter V,Sidi Y

更新日期：2000-12-08 00:00:00

abstract：:The ability of the cytosolic arylamine oxidase to convert structurally diverse aromatic and heterocyclic amines to mutagens in the Ames test was investigated using hepatic cytosol from Aroclor 1254-treated rats as the activation system. Using this system, only amino compounds containing at least three fused aromatic r...

journal_title：Cancer letters

authors： Marczylo T,Ioannides C

更新日期：1998-05-15 00:00:00

abstract：:Rituximab is the first anti-cancer antibody approved by the FDA for the treatment of B-cell lymphoma. However, its efficacy remains variable and often modest. Some patients are initially unresponsive to rituximab or later develop resistance to it, and require alternative therapies. Rituximab activity has been thought ...

journal_title：Cancer letters

authors： Lv M,Lin Z,Qiao C,Gen S,Lang X,Li Y,Feng J,Shen B

更新日期：2010-08-01 00:00:00

abstract：:Human cancer cells in vitro (NHIK 3025), derived from a carcinoma in situ are inactivated when exposed to visible light in the presence of hematoporphyrin. Irradiation at 4 degrees C results in much more efficient inactivation than irradiation at 37 degrees C. Furthermore, a given total light dose is more efficient wh...

journal_title：Cancer letters

authors： Moan J,Christensen T

更新日期：1979-05-01 00:00:00

abstract：:d-Alpha tocopheryl succinate (vitamin E succinate), which inhibited growth and survival, and induced differentiation in murine B-16 melanoma cells in culture, increased adenosine 3',5'cyclic monophosphate-(cAMP)-dependent protein kinase (PK) activity without increasing the cellular cAMP level. Prostaglandin (PG)A2, wh...

journal_title：Cancer letters

authors： Torelli S,Masoudi F,Prasad KN

更新日期：1988-03-01 00:00:00

abstract：:The desensitization mechanism of the EGF receptor (EGFR) is important for the regulation of cancer cells. Although the phosphorylation of EGFR at Tyr1045 and Ser1046/1047 (Ser1046/7) reportedly accounts for such desensitization, the precise mechanism still remains unknown. Therefore, the present study investigated the...

journal_title：Cancer letters

authors： Adachi S,Natsume H,Yamauchi J,Matsushima-Nishiwaki R,Joe AK,Moriwaki H,Kozawa O

更新日期：2009-05-08 00:00:00

abstract：:2'-Deoxy-N4-[2-(4-nitrophenyl)ethoxycarbonyl]-5-azacytidine (NPEOC-DAC), decitabine with a modification of the N4 position of the azacitidine ring can be used to inhibit DNA methyltransferase. This modification protects the azacitidine ring and can be cleaved by carboxylesterase to release decitabine. NPEOC-DAC was 23...

journal_title：Cancer letters

authors： Byun HM,Choi SH,Laird PW,Trinh B,Siddiqui MA,Marquez VE,Yang AS

更新日期：2008-08-08 00:00:00

abstract：:Lactoferrin, an iron-binding glycoprotein, exhibits suppressive effects on development of azoxymethane (AOM)-induced tumors in the rat colon, but the mechanisms are largely unknown. In this study, we investigated the effect of lactoferrin on the gene expression of 10 apoptosis-related molecules in colon mucosa of AOM-...

journal_title：Cancer letters

authors： Fujita K,Matsuda E,Sekine K,Iigo M,Tsuda H

更新日期：2004-09-15 00:00:00

abstract：:Oral squamous cell carcinoma (OSCC) is a characteristic locally aggressive tumor in which hypoxia levels are very high, causing a low response to chemotherapy and providing basic resistance to anticancer drugs. Tumoral hypoxia directly depends on hypoxia-inducible factors (HIF). The goal of this paper is to describe H...

journal_title：Cancer letters

authors： Pérez-Sayáns M,Suárez-Peñaranda JM,Pilar GD,Barros-Angueira F,Gándara-Rey JM,García-García A

更新日期：2011-12-26 00:00:00

abstract：:Transfection of the estrogen-dependent and poorly invasive MCF-7 human breast cancer cell line so that it stably overexpressed 12-lipoxygenase and secreted high levels of 12-hydroxyeicosatetraenoic acid when cultured with arachidonate resulted in rapid growth in athymic nude mice when compared with the parental line. ...

journal_title：Cancer letters

authors： Connolly JM,Rose DP

更新日期：1998-10-23 00:00:00

abstract：:Heat shock protein 90 (HSP90) is a highly conserved molecular chaperone that facilitates the maturation of a wide range of proteins, and it has been recognized as a crucial facilitator of oncogene addiction and cancer cell survival. Although HSP90 function is regulated by a variety of post-translational modifications,...

journal_title：Cancer letters

authors： Hamamoto R,Toyokawa G,Nakakido M,Ueda K,Nakamura Y

更新日期：2014-08-28 00:00:00

abstract：:The effect of pretreatment of skin of Sencar mice with topically applied tannic acid, quercetin and green tea polyphenols (GTP) on the skin tumor initiating activity of (+/-)-7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE-2) has been evaluated. The animals were pretreated with ...

journal_title：Cancer letters

authors： Khan WA,Wang ZY,Athar M,Bickers DR,Mukhtar H

更新日期：1988-09-01 00:00:00

abstract：:The oral administration of a single 20mg dose of 7,12-dimethylbenz[a]anthracene regularly and rapidly induces mammary cancer in 50 day-old Sprague-Dawley female rats [Experimental Leukemia and Mammary Cancer, 1979, p. 74]. Several mechanisms by which 7,12-dimethylbenz[a]anthracene induces mammary cancer have been prop...

journal_title：Cancer letters

authors： Horn J,Lehner AF,Flesher JW

更新日期：2005-04-08 00:00:00

abstract：:The effect of ligation of the left ureter on the development of lesions in the urinary bladder were investigated in male F344 rats treated with 0.05% N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) for 2 weeks followed by 0.002% N-ethyl-N-(4-hydroxybutyl)nitrosamine (EHBN) for 10 or 22 weeks. The lesions of the urinary b...

journal_title：Cancer letters

authors： Miyata Y,Fukushima S,Imaida K,Ito N

更新日期：1984-07-01 00:00:00

abstract：:Earlier studies performed both by us and by others have demonstrated that some n-3 and n-6 fatty acids can inhibit the growth of tumour cells in vitro. Though studies done with various types of oils rich in n-3 and n-6 fatty acids did show that the tumour incidence and growth can be modified, there were relatively few...

journal_title：Cancer letters

authors： Ramesh G,Das UN

更新日期：1998-01-30 00:00:00

abstract：:C57BL/10 mice transgenic for HLA-A2 were immunized with either a full-length DNA-construct of the tumor suppressor p53 or with a minigene encoding the p53-derived immunodominant peptide p53(264)LLGRNSFEV272 (L9V). Vaccination with the full-length p53 construct induced potent cytotoxic activity of splenocytes against L...

journal_title：Cancer letters

authors： Petersen TR,Bregenholta S,Pedersen LO,Nissen MH,Claesson MH

更新日期：1999-04-01 00:00:00

abstract：:Brain metastasis is an important cause of morbidity and mortality in cancer-patients. Breast tumor cells frequently metastasize to brain and initiate severe therapeutic complications. In the present study, we evaluated the anti-metastatic effects of 2'-hydroxyflavanone (2HF) alone and in combination with RLIP targeted...

journal_title：Cancer letters

authors： Singhal J,Singhal P,Horne D,Salgia R,Awasthi S,Singhal SS

更新日期：2018-12-01 00:00:00

abstract：:Overexpression of Myristoylated Alanine-Rich C Kinase Substrate (MARCKS) is implicated in drug resistance and progression of multiple myeloma (MM). The basis for MARCKS induction and impact on MM are not known. Here we show that microRNA-34a (miR-34a), regulates MARCKS translation and is under-expressed in drug-resist...

journal_title：Cancer letters

authors： Zhang L,Rastgoo N,Wu J,Zhang M,Pourabdollah M,Zacksenhaus E,Chen Y,Chang H

更新日期：2020-06-28 00:00:00

abstract：:The activity of cancer procoagulant (CP), prothrombin time (PT), activated partial thromboplastin time (APTT), the concentration of thrombin-antithrombin complexes (TAT) and the concentration of fibrinogen were analysed in blood of breast cancer patients scheduled for surgery. The serum level of CP activity was depend...

journal_title：Cancer letters

authors： Mielicki WP,Tenderenda M,Rutkowski P,Chojnowski K

更新日期：1999-11-01 00:00:00

abstract：:Although a correlation has been suggested between cigarette smoking and pancreatic cancer, studies on pathological changes in the pancreas of smokers are fragmentary. In the present study we examined histopathologically 73 pancreases obtained by autopsy from 42 heavy cigarette smokers and 31 non-smoker patients. One i...

journal_title：Cancer letters

authors： Tomioka T,Andrén-Sandberg A,Fujii H,Egami H,Takiyama Y,Pour PM

更新日期：1990-12-03 00:00:00

abstract：:Photodynamic action has been advocated as an alternative treatment of tumors but the most common used dyes, hematoporphyrin derivatives, are substrate for P-glycoprotein. This study investigated the MDR-reverting properties of methylene blue (MB) and compared the sensitivity to its photodynamic action (PDA) in five ce...

journal_title：Cancer letters

authors： Trindade GS,Farias SL,Rumjanek VM,Capella MA

更新日期：2000-04-14 00:00:00

abstract：:The widespread consumption of tea as beverage throughout the world has stimulated interest in the possibility of its use in chemoprevention of cancer. The present set of investigation was carried out to evaluate the anticarcinogenic activity of black tea using lung tumorigenesis model in Swiss albino mice. Diethylnitr...

journal_title：Cancer letters

authors： Shukla Y,Taneja P

更新日期：2002-02-25 00:00:00

abstract：:Epigenetic aberrations have been associated with cutaneous melanoma tumorigenesis and progression including dysregulated DNA gene promoter region methylation, histone modification, and microRNA. Several of these major epigenetic aberrations have been developed into biomarkers. Epigenetic biomarkers can be detected in ...

journal_title：Cancer letters

authors： Greenberg ES,Chong KK,Huynh KT,Tanaka R,Hoon DS

更新日期：2014-01-28 00:00:00

abstract：:Hepatocellular Carcinoma (HCC) in high-incidence areas (sub-Saharan Africa, South-Eastern Asia) often contains a somatic mutation at codon 249 in TP53 (R249S). This mutation is rare in low-incidence areas of Europe and the United States. There is evidence that R249S occurs as the result of mutagenesis by aflatoxin in ...

journal_title：Cancer letters

authors： Gouas D,Shi H,Hainaut P

更新日期：2009-12-01 00:00:00