Abstract:
:Oral squamous cell carcinoma (OSCC) is a characteristic locally aggressive tumor in which hypoxia levels are very high, causing a low response to chemotherapy and providing basic resistance to anticancer drugs. Tumoral hypoxia directly depends on hypoxia-inducible factors (HIF). The goal of this paper is to describe HIF basic biology and tumor cells (HIF-1α, mainly), analyzing the effects of its expression in OSCC, study its relation with other molecules such as nitric oxide (NO), carbonic anhydrase (CA) or VEGF and assess the possibility of its manipulation as a therapeutic target.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Pérez-Sayáns M,Suárez-Peñaranda JM,Pilar GD,Barros-Angueira F,Gándara-Rey JM,García-García Adoi
10.1016/j.canlet.2011.08.017subject
Has Abstractpub_date
2011-12-26 00:00:00pages
1-8issue
1eissn
0304-3835issn
1872-7980pii
S0304-3835(11)00504-0journal_volume
313pub_type
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