PTHrP stimulates prostate cancer cell growth and upregulates aldo-keto reductase 1C3.

abstract：PURPOSE:According to the CAO-/ARO-/AIO-94 trial of the German Rectal Cancer Study Group, pre-operative 5-fluorouracil (5-FU)-based long-term chemoradiotherapy (CT/RT) is recommended for patients with rectal cancer UICC stage II/III. However, despite the local benefit of neoadjuvant treatment, the overall prognostic val...

journal_title：Cancer letters

authors： Stoehlmacher J,Goekkurt E,Mogck U,Aust DE,Kramer M,Baretton GB,Liersch T,Ehninger G,Jakob C

更新日期：2008-12-18 00:00:00

abstract：:Pancreatic cancer is a highly lethal disease for which limited therapeutic options are available. Pancreatic cancer exhibits a pronounced collagen-rich stromal reaction, which induces chemoresistance by inhibiting drug diffusion into the tumor. Complementary treatment with oncolytic virus such as an oncolytic adenovir...

journal_title：Cancer letters

authors： Jung KH,Choi IK,Lee HS,Yan HH,Son MK,Ahn HM,Hong J,Yun CO,Hong SS

更新日期：2017-06-28 00:00:00

abstract：:The effects of vitamin E, vitamin B2 and selenite on DNA single strand breaks induced by Na2CrO4 were examined by alkaline elution. Incubation of Chinese hamster V-79 cells with alpha-tocopherol succinate (vitamin E) for 24 h prior to exposure to Na2CrO4 resulted in a decrease of DNA breaks produced by this compound. ...

journal_title：Cancer letters

authors： Sugiyama M,Ando A,Furuno A,Furlong NB,Hidaka T,Ogura R

更新日期：1987-12-01 00:00:00

abstract：:Ascorbate anion and glutathione were found to inhibit the aqueous reaction between nitrogen dioxide (NO2) and morpholine (MOR) and thereby prevented the formation of N-nitrosomorpholine (NMOR) and N-nitromorpholine (NTMOR) at both pH 7.4 and 12.5. These antioxidants are approximately 3 orders of magnitude more reactiv...

journal_title：Cancer letters

authors： Cooney RV,Ross PD,Bartolini GL

更新日期：1986-07-01 00:00:00

abstract：:Human epidermal growth factor receptor 2 (HER2), a member of the HER family of tyrosine kinases and a binding partner of Heat shock protein 90 (Hsp90), is found amplifies in approximately 25% breast cancers. Treatment of HER2+ breast cancers has been greatly improved in recent years, but the accompanying upregulation ...

journal_title：Cancer letters

authors： Huang W,Wu QD,Zhang M,Kong YL,Cao PR,Zheng W,Xu JH,Ye M

更新日期：2015-01-28 00:00:00

abstract：:Toxicity reduction of cisplatin is necessary for improved treatment of cancer. Here we have demonstrated the synergistic growth-inhibitory effect of cisplatin on cervical cancer cells in-combination with a nontoxic herbal carbazole alkaloid, mahanine. Mahanine enhanced cisplatin-induced apoptosis and reduced its effec...

journal_title：Cancer letters

authors： Das R,Bhattacharya K,Samanta SK,Pal BC,Mandal C

更新日期：2014-08-28 00:00:00

abstract：:Evidence is growing that low folate status may be a factor in the aetiology of several cancers, including breast cancer. The methylenetetrahydrofolate reductase gene (MTHFR), which has a key role in folate metabolism, is polymorphic. We report a case-control study of two functional polymorphisms in MTHFR, dietary fola...

journal_title：Cancer letters

authors： Sharp L,Little J,Schofield AC,Pavlidou E,Cotton SC,Miedzybrodzka Z,Baird JO,Haites NE,Heys SD,Grubb DA

更新日期：2002-07-08 00:00:00

abstract：:We previously showed that BARD1 is a shuttling protein with pro-apoptotic activity in MCF-7 breast cancer cells. BARD1 is expressed as splice variant isoforms in breast cancer. Here we characterized YFP-tagged BARD1 splice variants (beta, omega, phi, ΔRIN, epsilon) for subcellular localization and apoptotic efficacy. ...

journal_title：Cancer letters

authors： Marzec KA,Martino-Echarri E,Irminger-Finger I,Henderson BR

更新日期：2016-10-10 00:00:00

abstract：:Adeno-associated virus (AAV) is a non-pathogenic human parvovirus which has anti-tumor and anti-proliferation properties in tissue culture and animal studies. Furthermore, AAV infection is negatively associated with human cervical cancer. C-myc has been implicated in cervical cancer, and c-fos is involved in signal tr...

journal_title：Cancer letters

authors： Hermonat PL

更新日期：1994-06-30 00:00:00

abstract：:Although novel agents effective against malignant mesothelioma (MM) have been developed, the prognosis of patients with MM is still poor. We generated a DNA-chimeric siRNA against polo-like kinase-1 (PLK-1), which was more stable in human serum than the non-chimeric siRNA. The chimeric PLK-1 siRNA inhibited MM cell pr...

journal_title：Cancer letters

authors： Kawata E,Ashihara E,Nakagawa Y,Kiuchi T,Ogura M,Yao H,Sakai K,Tanaka R,Nagao R,Yokota A,Takeuchi M,Kimura S,Hirai H,Maekawa T

更新日期：2010-08-28 00:00:00

abstract：:Absent or altered differentiation is one of the major features of cancer cells. Histone deacetylases (HDACs) play a central role in the epigenetic regulation of gene expression. Aberrant activity of HDACs has been documented in several types of cancers, leading to the development of HDAC inhibitors (HDACi) as anti-tum...

journal_title：Cancer letters

authors： Botrugno OA,Santoro F,Minucci S

更新日期：2009-08-08 00:00:00

abstract：:Overexpression of HER-2/neu proto-oncogene is found in many human cancers including 20-30% of breast cancer and is a predictor of poor prognosis. To target breast cancer cells that overexpress HER-2/neu mRNA, we previously described a novel strategy that combines the principle of antisense (AS) and translational inhib...

journal_title：Cancer letters

authors： Li Z,Xia W,Fang B,Yan DH

更新日期：2001-12-28 00:00:00

abstract：:Bile acids are promoters of colon cancer; however, the mechanism(s) of action of this tumor promoter are largely unknown. Bile acids induce apoptosis in colon epithelial cells and it is probable that the modulation of apoptosis contributes, in part, to colon carcinogenesis. We tested the hypothesis that damage to mito...

journal_title：Cancer letters

authors： Washo-Stultz D,Crowley-Weber CL,Dvorakova K,Bernstein C,Bernstein H,Kunke K,Waltmire CN,Garewal H,Payne CM

更新日期：2002-03-28 00:00:00

abstract：:Of the erythropoietin-producing human hepatocellular receptors (Ephs), EphB4 has recently emerged as a potential target in several cancers due to its roles in modified cell migration and invasion. As little is known about the roles of EphB4 in glioma, we sought to investigate its function in glioma by in vitro cell mi...

journal_title：Cancer letters

authors： Kawahara Y,Furuta T,Sabit H,Tamai S,Dong Y,Jiapaer S,Zhang J,Zhang G,Oishi M,Miyashita K,Hayashi Y,Nakada M

更新日期：2019-05-01 00:00:00

abstract：:The effects of trisodium nitrilotriacetate monohydrate (Na3 NTA.H2O) nitrilotriacetic acid (H3NTA) and ammonium chloride (NH4Cl) on two-stage urinary bladder carcinogenesis were examined. Carcinogenesis was initiated by administration of 0.2% N-bis (2-hydroxypropyl)-nitrosamine (DHPN) to male Wistar rats in the drinki...

journal_title：Cancer letters

authors： Kitahori Y,Shimoyama T,Ohshima M,Matsuki H,Hashimoto H,Minami S,Konishi N,Hiasa Y

更新日期：1988-12-01 00:00:00

abstract：:The effects of treatment with naturally occurring antioxidants, selenium, beta-carotene, ferulic acid, esculin and eugenol during the promotional phase of tumor development were investigated in male F344 rats pre-treated with 1,2-dimethylhydrazine (DMH) and 1-methyl-1-nitrosourea (MNU). Animals were given 3 subcutaneo...

journal_title：Cancer letters

authors： Imaida K,Hirose M,Yamaguchi S,Takahashi S,Ito N

更新日期：1990-11-19 00:00:00

abstract：:Treatment of HeLa cells with the polyamine biosynthesis inhibitors difluoromethylornithine (DFMO) and/or methylglyoxal bis(guanylhydrazone) (MGBG) results in marked depression in levels of the cellular polyamines putrescine, spermidine and spermine. Cells in this polyamine-depleted state exhibited increased sensitivit...

journal_title：Cancer letters

authors： Snyder RD,Bhatt S

更新日期：1993-08-16 00:00:00

abstract：:The study describes the kinetics of demethylation of mononitrosocaffeidine (MNC), a new asymmetric N-nitrosamine derived from caffeine. The demethylation of its precursor compound caffeidine was also studied. The results presented here suggest (a) that liver microsomes from fasted rats preferentially demethylate the N...

journal_title：Cancer letters

authors： Razdan R,Frei E,Spiegelhalder B,Siddiqi M

更新日期：1994-04-29 00:00:00

abstract：:Binding of 1-nitro[14C]pyrene (1-NP) or its metabolites to cellular DNA and protein in cultures of rabbit alveolar macrophages and lung and tracheal tissues was examined. DNA binding was highest in tracheal tissue (136.9 +/- 18.3 pmol 1-NP/mg DNA). DNA binding in macrophages and lung tissue was one-fifth of the level ...

journal_title：Cancer letters

authors： King LC,Jackson M,Ball LM,Lewtas J

更新日期：1983-07-01 00:00:00

abstract：:Oral treatment with reduced glutathione for 10 weeks has no effect on the development of tumours from aflatoxin B1-induced gamma-glutamyl transpeptidase-positive pre-neoplastic focal lesions. ...

journal_title：Cancer letters

authors： Neal GE,Legg RF

更新日期：1983-11-01 00:00:00

abstract：:Dysregulation of circular RNA Foxo3 (circFoxo3) has been reported to be involved in breast cancer and non-small lung cancer progression. However, little is known about the role of circFoxo3 in prostate cancer, which the present study seeks to investigate. CircFoxo3 expression was analyzed in 22 low-grade prostate canc...

journal_title：Cancer letters

authors： Shen Z,Zhou L,Zhang C,Xu J

更新日期：2020-01-01 00:00:00

abstract：:Aberrant activation of signal transducer and activator of transcription 3 (STAT3) is frequently observed in multiple myeloma (MM) cancer and can upregulate the expression of several genes involved in proliferation, survival, metastasis, and angiogenesis. The effect of farnesol (FOH) on STAT3 activation, associated pro...

journal_title：Cancer letters

authors： Lee JH,Kim C,Kim SH,Sethi G,Ahn KS

更新日期：2015-05-01 00:00:00

abstract：:The capacity of the human adrenal gland to metabolize various xenobiotics was investigated. Adrenal microsomal and mitochondrial preparations showed a maximal absorption at 450 nm for dithionite-reduced cytochromes in the presence of carbon monoxide. Occasionally, absorption maxima at 448 nm were observed with both mi...

journal_title：Cancer letters

authors： Papadopoulos D,Seidegard J,Rydström J

更新日期：1984-02-01 00:00:00

abstract：:Serial determinations of urinary biopterin were performed in rats during the development of lung tumors induced by radon inhalation and 5,6-benzonaphtoflavone administration. A striking increase in biopterin levels was observed in animals which developed single or multiple epidermoid carcinoma of the lung and this inc...

journal_title：Cancer letters

authors： Mura P,Morlier JP,Barriere M,Bredon P,Papet Y,Chameaud J

更新日期：1990-10-08 00:00:00

abstract：:Gelatinases play important roles in tumor progression and are abundantly expressed in a variety of malignant tumors. Antibody targeting gelatinases is a possible avenue to fight against cancer. However, antibody alone can not achieve curative efficacy. Herein, we demonstrated the intensified targeting therapy of a tan...

journal_title：Cancer letters

authors： Zhong G,Zhang S,Li Y,Liu X,Gao R,Miao Q,Zhen Y

更新日期：2010-09-01 00:00:00

abstract：:The transcription factor Forkhead Box P3 (Foxp3) has been shown to play important roles in the occurring of regulatory T cells (Tregs). Limited evidence indicated that it was also expressed in tissues other than thymus and spleen, while, very recently, it was identified as a suppressor gene in breast cancer. However, ...

journal_title：Cancer letters

authors： Zhang HY,Sun H

更新日期：2010-01-01 00:00:00

abstract：:The vectors PAI2, C595 and Herceptin target the membrane-bound uPA, MUC1 and HER2 antigens expressed by cancer cells, respectively. The expression of these receptors was tested in the ovarian cancer cell line OVCAR-3; MUC-1 was strongly expressed (3+), uPA moderately expressed (2+), but HER2 was negative (-). The alph...

journal_title：Cancer letters

authors： Song YJ,Qu CF,Rizvi SM,Li Y,Robertson G,Raja C,Morgenstern A,Apostolidis C,Perkins AC,Allen BJ

更新日期：2006-03-28 00:00:00

abstract：:Rats bearing the Yoshida AH-130 ascites hepatoma, a cachectic rat tumour, showed signs of important muscle wasting with reduced muscle weights. This phenomenon was associated with a decreased rate of in vivo alanine oxidation as measured by the production of 14CO2 from [U-14C]alanine intragastrically administered. It ...

journal_title：Cancer letters

authors： García-Martínez C,López-Soriano FJ,Argilés JM

更新日期：1994-12-09 00:00:00

abstract：:Considerable evidences have shown that both heat shock transcription factor 1 (HSF1) and autophagy can attenuate the sensitivity of hepatocellular carcinoma (HCC) cells to chemotherapeutic reagents. However, it is still little known whether HSF1 is associated with autophagy in regulating the chemosensitivity of HCC ce...

journal_title：Cancer letters

authors： Zhang N,Wu Y,Lyu X,Li B,Yan X,Xiong H,Li X,Huang G,Zeng Y,Zhang Y,Lian J,Ni Z,He F

更新日期：2017-11-28 00:00:00

abstract：:Chronic exposure to cadmium is known to be a risk factor for human prostate cancer. Despite over-whelming evidence of cadmium causing carcinogenicity in humans, the specific underlying molecular mechanisms that govern metal-induced cellular transformation remain unclear. Acute exposure (up to 72 h) to cadmium induces ...

journal_title：Cancer letters

authors： Kolluru V,Pal D,Papu John AMS,Ankem MK,Freedman JH,Damodaran C

更新日期：2017-11-01 00:00:00