Novel Hsp90 inhibitor FW-04-806 displays potent antitumor effects in HER2-positive breast cancer cells as a single agent or in combination with lapatinib.

abstract：:Not-targeted effects represent a paradigm shift from the "DNA centric" view that ionizing radiation only elicits biological effects and subsequent health consequences as a result of an energy deposition event in the cell nucleus. While this is likely true at higher radiation doses (>1 Gy), at low doses (<100 mGy) non-...

journal_title：Cancer letters

authors： Morgan WF,Sowa MB

更新日期：2015-01-01 00:00:00

abstract：:The tumorigenicity of 7-chlorobenz[a]anthracene (7-Cl-BA, and environmental contaminant, and 7 bromobenz[a]anthracene (7-Br-BA) was determines in the male B6C3F(1) newborn mouse. Mice receiving 7-Cl-BA and 7-Br-BA by i.p. injections at a dose of 1600 nmol per mouse on 1, 8, and 15 days after birth developed 92 and 96%...

journal_title：Cancer letters

authors： Fu PP,Von Tungeln LS,Zhan DJ,Bucci T

更新日期：1996-03-19 00:00:00

abstract：:Preventive intervention of colorectal cancer has become essential as a major portion of the population may develop the disease at some points during their lives. Diet and nutrition play an important role during this multistep colon carcinogenic process. Inhibitory activity of aqueous suspensions of garlic and tomato, ...

journal_title：Cancer letters

authors： Sengupta A,Ghosh S,Das S

更新日期：2004-05-28 00:00:00

abstract：:Chronic elevated free fatty (FFA) levels are linked to metabolic disorders and tumorigenesis. However, the molecular mechanism by which FFAs induce cancer remains poorly understood. Here, we show that the tumor suppressor PTEN protein levels were decreased in high fat diet (HFD) fed mice. As palmitic acid (PA, C16:0) ...

journal_title：Cancer letters

authors： Bai D,Wu Y,Deol P,Nobumori Y,Zhou Q,Sladek FM,Liu X

更新日期：2021-01-01 00:00:00

abstract：:The intracellular concentrations of adenosine 3',5'-cyclic monophosphate (cAMP) in colonic tumors induced in adult male Holtzman rats by 1,2-dimethylhydrazine (DMH) were found to be 1/2 the concentration found in normal large bowel tissue. Intracellular concentrations of guanosine 3'-5'-cyclic monophosphate (cGMP) in ...

journal_title：Cancer letters

authors： Stevens RH,Loven DP,Osborne JW,Prall JP,Lawson AJ

更新日期：1978-01-01 00:00:00

abstract：:Interleukin-2 (IL-2) and granulocyte-macrophage colony stimulating factor (GM-CSF) facilitate the maturation and functioning of injected DC. We developed a method of in situ electroporation using IL-2 and GM-CSF genes (EGT/cytokines), followed by intra-tumoral (i.t.) immature DC to determine the immune response at the...

journal_title：Cancer letters

authors： Wang YS,Tsang YW,Chi CH,Chang CC,Chu RM,Chi KH

更新日期：2008-08-08 00:00:00

abstract：:N-Acetyltransferase activities with p-aminobenzoic acid and 2-aminofluorene were determined in Anisakis simplex, a nematode found in the intestine of the salt water fish Trichiurus lepturus. The N-acetyltransferase activity was determined using an acetyl CoA recycling assay and high pressure liquid chromatography. The...

journal_title：Cancer letters

authors： Chung JG,Kuo HM,Lin TH,Ho CC,Lee JH,Lai JM,Levy GN,Weber WW

更新日期：1996-08-23 00:00:00

abstract：:Benign mammary gross cystic disease is the most common breast lesion; women with apocrine changes of epithelium lining the cysts are at higher risk for developing breast cancer than the normal population. Total cholesterol, high- and low-density lipoproteins fractions, triglycerides and phospholipids, lipase activity ...

journal_title：Cancer letters

authors： Mannello F,Bocchiotti GD,Morano FP,Fratepietro LM,Gazzanelli G

更新日期：1996-01-02 00:00:00

abstract：:Modifying effects of 5-hydroxy-4-(2-phenyl-(E)-ethenyl)-2(5H)-furanone, a novel synthesized retinoid (KYN-54), on intestinal carcinogenesis were examined in a rat model using azoxymethane (AOM). A total of ninety male F344 rats, 6 weeks old, were divided into 4 groups. Group 1 (20 rats) was fed a diet containing KYN-5...

journal_title：Cancer letters

authors： Mori H,Yoshimi N,Sugie S,Tanaka T,Morishita Y,Jinlong G,Tamai Y,Torihara M,Yamahara J

更新日期：1992-09-30 00:00:00

abstract：:cDNA libraries were generated from the prostate gland tissue obtained from a normal donor and from a patient with prostate cancer. Subtractive cDNA cloning was used to identify phenotype-specific cDNA sequences from both normal and cancerous prostate tissue. One clone, pN44, isolated from normal prostate tissue, codes...

journal_title：Cancer letters

authors： Liu AY,Bradner RC,Vessella RL

更新日期：1993-10-15 00:00:00

abstract：:Although it is well known that ovarian endometriosis occasionally gives rise to ovarian cancers with specific histology such as endometrioid and clear cell carcinomas, its etiology is not fully understood. We have shown that a stressful microenvironment within the endometriotic cyst may lead to cancer development by i...

journal_title：Cancer letters

authors： Mandai M,Matsumura N,Baba T,Yamaguchi K,Hamanishi J,Konishi I

更新日期：2011-11-28 00:00:00

abstract：:The p53 tumor suppressor gene is often mutated in various human cancers. Recently, the p53 codon 72 polymorphism has been extensively studied to determine the risk factors responsible for cancer formation. We investigated the genotype distribution of the p53 codon 72 polymorphism in 112 male urothelial cancer cases an...

journal_title：Cancer letters

authors： Kuroda Y,Tsukino H,Nakao H,Imai H,Katoh T

更新日期：2003-01-10 00:00:00

abstract：:The effects of vitamin E, vitamin B2 and selenite on DNA single strand breaks induced by Na2CrO4 were examined by alkaline elution. Incubation of Chinese hamster V-79 cells with alpha-tocopherol succinate (vitamin E) for 24 h prior to exposure to Na2CrO4 resulted in a decrease of DNA breaks produced by this compound. ...

journal_title：Cancer letters

authors： Sugiyama M,Ando A,Furuno A,Furlong NB,Hidaka T,Ogura R

更新日期：1987-12-01 00:00:00

abstract：:The intrinsic limits of conventional ultrasound microbubble contrast agent greatly promoted the development and application of various nanomaterials for more efficient cancer ultrasound theranostics. Considerable successes have been achieved in the field of ultrasound molecular imaging and targeted therapy for tumor b...

journal_title：Cancer letters

authors： Zhou LQ,Li P,Cui XW,Dietrich CF

更新日期：2020-02-01 00:00:00

abstract：:Oncogenic transformation of mouse C3H10T1/2 cells induced by X-rays was suppressed in the presence of extract of Rooibos tea, Aspalathus linealis. Transformation was reduced with increased concentration of the extract, so that at an extract concentration of 10%, transformation incidence was similar to the spontaneous ...

journal_title：Cancer letters

authors： Komatsu K,Kator K,Mitsuda Y,Mine M,Okumura Y

更新日期：1994-02-28 00:00:00

abstract：:Heterocyclic amines (HCAs) present in cooked foods are suggested to be involved in human breast cancer development. Estrogen plays a pivotal role in mammary gland carcinogenesis. Therefore, we designed an in vivo experiment to investigate potential estrogenic effects of two HCAs, 2-amino-3-methylimidazo[4,5-f]quinolin...

journal_title：Cancer letters

authors： Kawamori T,Uchiya N,Watanabe K,Ohta T,Sugimura T,Wakabayashi K

更新日期：2001-01-10 00:00:00

abstract：:One of the frontiers in cancer personalized-medicine aims at glycosylation. Cells are covered with a dense sugar coat of glycolipids, glycoproteins and free glycans. In cancer, the characteristic cell surface glycosylation is frequently transformed due to altered expression of glycan-modifying enzymes. This often lead...

journal_title：Cancer letters

authors： Padler-Karavani V

更新日期：2014-09-28 00:00:00

abstract：:Bcl-2 agonist of cell death (BAD) is a BH3-only member of the Bcl-2 family which possesses important regulatory function in apoptosis. BAD has also been shown to possess many non-apoptotic functions closely linked to cancer including regulation of glycolysis, autophagy, cell cycle progression and immune system develop...

journal_title：Cancer letters

authors： Bui NL,Pandey V,Zhu T,Ma L,Basappa,Lobie PE

更新日期：2018-02-28 00:00:00

abstract：:BRCA1 regulates gene transcription as part of its tumor suppressor function. Prior studies on BRCA1 transactivation did not account for the impact of its binding partner, BARD1. Here we tested the effect of BARD1 on BRCA1 transactivation of the p21 and Gadd45 promoters. We show that BARD1 promoted nuclear accumulation...

journal_title：Cancer letters

authors： Fabbro M,Henderson BR

更新日期：2008-05-18 00:00:00

abstract：:The presence and the involvement of cancer stem-like cells (CSCs) in tumor initiation and progression, and chemo-resistance are documented. Herein, we functionally analyzed melanoma stem-like cells (MSC)/CD133(+) cells on their resistance and response to taxol-induced apoptosis. Besides being taxol resistant, the CD13...

journal_title：Cancer letters

authors： El-Khattouti A,Selimovic D,Haïkel Y,Megahed M,Gomez CR,Hassan M

更新日期：2014-02-01 00:00:00

abstract：:Treatment resistance in acute lymphoblastic leukemia (ALL) is often caused by defects in programmed cell death, e.g. by overexpression of Inhibitor of Apoptosis (IAP) proteins. Here, we report that small-molecule Smac mimetics (i.e. BV6, LCL161, birinapant) that neutralize x-linked IAP (XIAP), cellular IAP (cIAP)1 and...

journal_title：Cancer letters

authors： Gerges S,Rohde K,Fulda S

更新日期：2016-05-28 00:00:00

abstract：:The synthetic compound 1,2-dimethylhydrazine is employed in carcinogenesis studies because of its reliable and specific ability to produce colon tumors in rodents. Male Fischer rats were treated at 7 weeks of age with a single oral dose of 1,2-dimethylhydrazine (35 mg/kg) and examined at autopsy 1.5 years later when t...

journal_title：Cancer letters

authors： Southern JT,Schiller CM

更新日期：1981-10-01 00:00:00

abstract：:Caffeine may very well be the most frequently ingested neuroactive drug in the world. Mechanistically, caffeine has been reported to affect cell cycle function, induce programmed cell death or apoptosis and perturb key cell cycle regulatory proteins. Although the effects of caffeine have been heavily investigated, muc...

journal_title：Cancer letters

authors： Bode AM,Dong Z

更新日期：2007-03-08 00:00:00

abstract：:Staurosporine (ST), a potent inhibitor of protein kinase C (PKC), was evaluated for its effect on the proliferation of HT-29 colon adenocarcinoma cells; PKC is associated with increased colon cell proliferation. ST inhibited cell proliferation in a time- and concentration-dependent manner by up to 90%. It also blocked...

journal_title：Cancer letters

authors： Qiao L,Koutsos M,Tsai LL,Kozoni V,Guzman J,Shiff SJ,Rigas B

更新日期：1996-10-01 00:00:00

abstract：:Exosomes are structurally and functionally pleiotropic nano-sized (~30-150 nm in diameter) extracellular vesicles (EVs) with endosomal origin. These vesicles are secreted by almost all cells and play a significant role in intercellular communication and bio-waste disposal. To a great extent, exosomes represent biologi...

journal_title：Cancer letters

authors： Kumar A,Deep G

更新日期：2020-09-28 00:00:00

abstract：:Efficacy of a safe and clinically utilized polyethylene glycol formulation (PEG-3350) to suppress intestinal tumors was investigated in the Apc(min) mouse-model of experimental carcinogenesis. Furthermore, based on our previous finding on the induction of apoptosis in HT-29 cells by PEG, we evaluated its ability to st...

journal_title：Cancer letters

authors： Roy HK,Gulizia J,DiBaise JK,Karolski WJ,Ansari S,Madugula M,Hart J,Bissonnette M,Wali RK

更新日期：2004-11-08 00:00:00

abstract：:Here we found that dual mTORC1/2 inhibitor AZD-2014 significantly inhibited RCC cell survival and growth, with higher efficiency than conventional mTORC1 inhibitors rapamycin and RAD001. RCC cell apoptosis was also induced by AZD-2014. AZD-2014 disrupted mTORC1/2 assembly and activation, while downregulating HIF-1α/2α...

journal_title：Cancer letters

authors： Zheng B,Mao JH,Qian L,Zhu H,Gu DH,Pan XD,Yi F,Ji DM

更新日期：2015-02-28 00:00:00

abstract：:The role of p53 in the evolution of non-Hodgkin's lymphomas (NHL) is unclear. Mutations of the p53 gene appear to be relatively uncommon but stabilized p53 protein, as detected by immunohistochemistry, has indicated a more frequent involvement of p53. As dysfunction of p53 protein has also been suggested to occur afte...

journal_title：Cancer letters

authors： Finnegan MC,Goepel JR,Royds J,Hancock BW,Goyns MH

更新日期：1994-11-11 00:00:00

abstract：:Normal tissue injury may lead to severe, life threatening, late side effects after therapeutic use of irradiation. Neurological complications caused by radiation of the spinal cord are ascribed to progressive, irreversible damage to the vasculature. Hyperbaric oxygen (HBO) is known to induce angiogenesis in irradiated...

journal_title：Cancer letters

authors： Sminia P,van der Kleij AJ,Carl UM,Feldmeier JJ,Hartmann KA

更新日期：2003-02-28 00:00:00

abstract：:The peptide aptamer DUP-1 targets prostate-specific membrane antigen (PSMA)-negative cells, while the RNA aptamer A10-3.2 targets PSMA-positive prostate cancer cells. Moreover, the tumor-suppressor gene phosphatase and tensin homolog (PTEN) and the chemotherapeutic agent doxorubicin (DOX) effectively inhibit prostate ...

journal_title：Cancer letters

authors： Jing P,Cao S,Xiao S,Zhang X,Ke S,Ke F,Yu X,Wang L,Wang S,Luo Y,Zhong Z

更新日期：2016-12-28 00:00:00