Abstract:
:Glioblastoma multiforme (GBM) is a brain tumor with a high mortality rate. Surgical resection combined with radiotherapy and chemotherapy is the standard treatment for GBM patients, but the 5-year survival rate of patients despite this treatment is low. Immunotherapy has attracted increasing attention in recent years. As the pioneer and the main effector cells of immunotherapy, T cells play a key role in tumor immunotherapy. However, the T cells in GBM microenvironment are inhibited by the highly immunosuppressive environment of GBM, posing huge challenges to T cell-based GBM immunotherapy. This review summarizes the effects of the GBM microenvironment on the infiltration and function of different T-cell subsets and the possible strategies to overcome immunosuppression, and thus enhance the effectiveness of GBM immunotherapy.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Wang H,Zhou H,Xu J,Lu Y,Ji X,Yao Y,Chao H,Zhang J,Zhang X,Yao S,Wu Y,Wan Jdoi
10.1016/j.canlet.2020.09.028subject
Has Abstractpub_date
2021-01-01 00:00:00pages
134-143eissn
0304-3835issn
1872-7980pii
S0304-3835(20)30498-5journal_volume
496pub_type
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