Abstract:
:The plant sterol guggulsterone has recently been shown to have anti-tumorigenic potential. This study was designed to investigate the anti-tumor efficacy of guggulsterone and to elucidate its molecular mechanisms in colon cancer. Guggulsterone significantly increased apoptosis in HT-29 cells by activating caspases-3 and -8. Furthermore, guggulsterone decreased cIAP-1, cIAP-2, and Bcl-2 levels and increased the levels of truncated Bid, Fas, p-JNK, and p-c-Jun. The size of HT-29 xenograft tumors in guggulsterone-treated mice was significantly smaller than of the size of tumors in control mice. The present study suggests a potential therapeutic use for this compound in the treatment of colorectal cancer.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
An MJ,Cheon JH,Kim SW,Kim ES,Kim TI,Kim WHdoi
10.1016/j.canlet.2009.01.026subject
Has Abstractpub_date
2009-06-28 00:00:00pages
93-100issue
1eissn
0304-3835issn
1872-7980pii
S0304-3835(09)00060-3journal_volume
279pub_type
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