Hyperthermia on immune regulation: a temperature's story.

abstract：:The identification of frameshift mutations in the coding region of the bax gene in Western cases of hereditary non-polyposis colorectal cancer provided evidence that the disease could be caused by the disruption of a tumor suppressor gene associated with microsatellite instability. In order to determine whether this o...

journal_title：Cancer letters

authors： Sakakibara T,Nakamura T,Yamamoto M,Matsuo M

更新日期：1998-02-27 00:00:00

abstract：:Associations between lung cancer risk and common polymorphisms in the DNA repair genes xeroderma pigmentosum complementation group D (XPD), X-ray repair cross-complementing group 1 (XRCC1), XRCC3 and apurinic/apyrimidinic endonuclease/redox factor 1 were examined within a randomized clinical trial designed to determin...

journal_title：Cancer letters

authors： Misra RR,Ratnasinghe D,Tangrea JA,Virtamo J,Andersen MR,Barrett M,Taylor PR,Albanes D

更新日期：2003-03-10 00:00:00

abstract：:Internal tandem duplication (ITD) of the juxtamembrane region of FMS-like tyrosine kinase-3 (FLT3) receptor is a common type of mutation in adult acute myeloid leukemia (AML), and patient response to FLT3 inhibitors appears to be transient due to the emergence of drug resistance. We established two sorafenib-resistant...

journal_title：Cancer letters

authors： Huang A,Ju HQ,Liu K,Zhan G,Liu D,Wen S,Garcia-Manero G,Huang P,Hu Y

更新日期：2016-07-28 00:00:00

abstract：:Transfection of the estrogen-dependent and poorly invasive MCF-7 human breast cancer cell line so that it stably overexpressed 12-lipoxygenase and secreted high levels of 12-hydroxyeicosatetraenoic acid when cultured with arachidonate resulted in rapid growth in athymic nude mice when compared with the parental line. ...

journal_title：Cancer letters

authors： Connolly JM,Rose DP

更新日期：1998-10-23 00:00:00

abstract：:In esophageal squamous cell carcinoma (SCC), we used immunohistochemical analysis to further elucidate the correlation of p53 protein expression with clinicopathological factors, as well as with risk factors, such as tobacco smoking, alcohol consumption and a family history of cancer, using odds ratios (ORs). The expr...

journal_title：Cancer letters

authors： Kato H,Yoshikawa M,Miyazaki T,Nakajima M,Fukai Y,Tajima K,Masuda N,Tsukada K,Fukuda T,Nakajima T,Kuwano H

更新日期：2001-06-10 00:00:00

abstract：:Oral squamous cell carcinoma (OSCC) is associated with a high potential of tumor recurrence and metastasis, leading to poor prognosis. Cell motility is an important factor in the progression and metastasis of cancers. Recently, Fascin has been linked to tumor progression by induction of cell motility. However, the pre...

journal_title：Cancer letters

authors： Lee TK,Poon RT,Man K,Guan XY,Ma S,Liu XB,Myers JN,Yuen AP

更新日期：2007-09-08 00:00:00

abstract：:Matrix Gla protein (MGP) is a vitamin K-dependent extracellular matrix protein commonly found in a variety of tissues. In this study, we describe the potential use of MGP gene expression as the tumor marker of colorectal cancer. A decrease in expression of the MGP gene was also discovered in colorectal cancer using di...

journal_title：Cancer letters

authors： Fan C,Sheu D,Fan H,Hsu K,Allen Chang C,Chan E

更新日期：2001-04-10 00:00:00

abstract：:We previously identified Hop as over expressed in invasive pancreatic cancer cell lines and malignant tissues of pancreatic cancer patients, suggesting an important role for Hop in the biology of invasive pancreatic cancer. Hop is a co-chaperone protein that binds to both Hsp70/Hsp90. We hypothesised that by targeting...

journal_title：Cancer letters

authors： Walsh N,Larkin A,Swan N,Conlon K,Dowling P,McDermott R,Clynes M

更新日期：2011-07-28 00:00:00

abstract：:Smoking women are probably at a higher risk to develop lung cancer than men. Different explanations exist for these findings, a gender-specific impairment of tobacco carcinogen metabolism being one of them. In this study, we examined the inhibition of NNK reduction to NNAL, the first and most important detoxication st...

journal_title：Cancer letters

authors： Stapelfeld C,Neumann KT,Maser E

更新日期：2017-10-01 00:00:00

abstract：:A newly found human retrovirus, adult T-cell leukemia virus (ATLV) was shown by means of membrane immunofluorescence to bind to various hematopoietic cells including T-, B- and non-T, non-B-cell lines. Partially purified viral gp46 from culture fluids of ATL virus producer lines also bound efficiently to an ATLV-negat...

journal_title：Cancer letters

authors： Yamamoto N,Chosa T,Koyanagi Y,Tochikura T,Schneider J,Hinuma Y

更新日期：1984-01-01 00:00:00

abstract：:In this study, we demonstrated that thrombin activates protein kinase C (PKC), mitogen activated protein kinases (MAP kinases), transcription factor nuclear factor-kappa B (NF-kappa B), and cAMP-dependent protein kinase (PKA) in the human renal carcinoma cell line A-498. In addition, it enhanced the migratory capacity...

journal_title：Cancer letters

authors： Kaufmann R,Junker U,Junker K,Nuske K,Ranke C,Zieger M,Scheele J

更新日期：2002-06-28 00:00:00

abstract：:SIRT2, a member of the sirtuin family, is involved in the regulation of a variety of physiological functions. In addition, SIRT2 has been studied in the context of pathological conditions including neurodegenerative diseases, metabolic syndrome, and cancer. The effect of SIRT2 on cancer cell growth depends on cancer t...

journal_title：Cancer letters

authors： Cheon MG,Kim W,Choi M,Kim JE

更新日期：2015-01-28 00:00:00

abstract：:Immunometabolism, which has important implications in cancer biology, has emerged as a major regulator of different immune cell types. Various factors that integrate metabolic switches within immune cells with signal directed program that promote or inhibit their functions remain largely unidentified. Furthermore, sex...

journal_title：Cancer letters

authors： Zi Xu YX,Ande SR,Mishra S

更新日期：2018-02-28 00:00:00

abstract：:Neuroendocrine (carcinoid) tumours of the thymus are rare neoplasms characterized by a highly malignant clinical behavior. Some of these tumors are associated with MEN1. In this study we evaluated 10 cases of sporadic thymic neuroendocrine tumours using immunohistochemistry and comparative genomic hybridization (CGH)....

journal_title：Cancer letters

authors： Rieker RJ,Aulmann S,Penzel R,Schnabel PA,Blaeker H,Esposito I,Morresi-Hauf A,Otto HF,Hecker E,Dienemann H,Schirmacher P,Mechtersheimer G

更新日期：2005-06-01 00:00:00

abstract：:The primary aim of this study was to find novel chemopreventive agents effective against breast cancer. Endoplasmic reticulum (ER) stress can induce apoptosis through the unfolded protein response (UPR). 2'-Hydroxy-2,3,5'-trimethoxychalcone (DK143) is a synthetic flavonoid derivative. The present study provides eviden...

journal_title：Cancer letters

authors： Lee DH,Jung Jung Y,Koh D,Lim Y,Lee YH,Shin SY

更新日期：2016-03-01 00:00:00

abstract：:Treatment of mouse lymphoma L5178Y cells with spermine in Fischer's medium containing bovine serum lead to formation of chromatid aberrations. The cause of this effect seems to be that bovine serum contains spermine oxidase which catalyzes oxidation of spermine to unstable aldehyde derivatives (oxidized spermine) and ...

journal_title：Cancer letters

authors： Bouzyk E,Rosiek O

更新日期：1988-02-01 00:00:00

abstract：:Diet is one of the elements that may influence the development of lung cancer. To ascertain the relationship between meat and fish consumption and the appearance of this disease, a case-control study was conducted on a population in Galicia (NW Spain), with a sample of 295 cases and 322 controls. All cases had histolo...

journal_title：Cancer letters

authors： Dosil-Díaz O,Ruano-Ravina A,Gestal-Otero JJ,Barros-Dios JM

更新日期：2007-07-08 00:00:00

abstract：:This study was carried out to evaluate the diagnostic utility of autofluorescence photography for oral mucosal lesions. The materials consisted of 15 chemically-induced lesions containing carcinomas in 15 hamsters, and 32 oral lesions in 30 patients. In the animal models, orange fluorescence was detected in all squamo...

journal_title：Cancer letters

authors： Onizawa K,Saginoya H,Furuya Y,Yoshida H

更新日期：1996-11-12 00:00:00

abstract：:Interleukin-6 (IL-6) contributes to a multitude of physiological and pathophysiological processes. We sought to determine the level of the IL-6 in serum and tumoral tissue of patients with staging of the tumor and whether serum IL-6 level in patients with colorectal cancer correlate with tumoral tissue level of it. Se...

journal_title：Cancer letters

authors： Esfandi F,Mohammadzadeh Ghobadloo S,Basati G

更新日期：2006-11-28 00:00:00

abstract：:Suicide gene therapy could be an attractive addition to the treatment of ovarian carcinomas, for which acquired chemoresistance frequently results in treatment failure. Here we show that transfection of the HSV-tk gene, followed by incubation with up to 1 mM ganciclovir fails to induce cell death in SKOV3 chemoresista...

journal_title：Cancer letters

authors： Ziller C,Lincet H,Muller CD,Staedel C,Behr JP,Poulain L

更新日期：2004-08-20 00:00:00

abstract：:Epigenetic modification of miR-429 can manipulate liver T-ICs via targeting the RBBP4/E2F1/Oct4 axis, which might be crucial for hepatocarcinogenesis. However, whether miR-429 plays a role in regulating metastasis of hepatocellular carcinoma is still unclear. Using quantitative methylation analysis and real-time PCR, ...

journal_title：Cancer letters

authors： Tang J,Li L,Huang W,Sui C,Yang Y,Lin X,Hou G,Chen X,Fu J,Yuan S,Li S,Wen W,Tang S,Cao D,Wu M,Chen L,Wang H

更新日期：2015-08-01 00:00:00

abstract：:High doses of folate and its quinazoline analogue with antitumour activity, N10-propargyl-5,8-dideazafolic acid (CB 3717), caused severe renal damage in mice, leading in the case of folate to death. The mouse kidneys increased in weight, which was accompanied by time- and dose-dependent induction of ornithine decarbox...

journal_title：Cancer letters

authors： Manteuffel-Cymborowska M,Chmurzyńska W,Grzelakowska-Sztabert B

更新日期：1991-09-01 00:00:00

abstract：:Effects of cis-dichlorodiammineplatinum-(II) (cis-DDP), an anticancer agent, on capping of membrane receptors were investigated in mouse spleen cells in vitro, using fluorescein labeled ligands. Cap formations of surface immunoglobulin and of concanavalin A receptors were significantly reduced by cis-DDP in relation t...

journal_title：Cancer letters

authors： Tsokos GC,Choie DD

更新日期：1980-09-01 00:00:00

abstract：:The di-methyl-, di-ethyl-, di-propyl-, di-normal butyl-, and di-iso-butyl-ethers of hematoporphyrin were synthesized and shown to possess chromatographic properties similar to those of the tumorlocalizing components of hematoporphyrin derivative (Hpd). The cellular uptake of these ethers, as well as their retention in...

journal_title：Cancer letters

authors： Moan J,Rimington C,Sommer S

更新日期：1987-03-01 00:00:00

abstract：:MicroRNAs (miRNAs) are a group of non-coding RNAs that play a crucial role in post-transcriptional gene regulation and act as indispensable mediators in several critical biological processes, including tumorigenesis, tissue homeostasis, and regeneration. MiR-424 and miR-503 are intragenic miRNAs that are clustered on ...

journal_title：Cancer letters

authors： Wu Y,Wang W,Yang AG,Zhang R

更新日期：2020-12-01 00:00:00

abstract：:Lactoferrin, an iron-binding glycoprotein, exhibits suppressive effects on development of azoxymethane (AOM)-induced tumors in the rat colon, but the mechanisms are largely unknown. In this study, we investigated the effect of lactoferrin on the gene expression of 10 apoptosis-related molecules in colon mucosa of AOM-...

journal_title：Cancer letters

authors： Fujita K,Matsuda E,Sekine K,Iigo M,Tsuda H

更新日期：2004-09-15 00:00:00

abstract：:The plant sterol guggulsterone has recently been shown to have anti-tumorigenic potential. This study was designed to investigate the anti-tumor efficacy of guggulsterone and to elucidate its molecular mechanisms in colon cancer. Guggulsterone significantly increased apoptosis in HT-29 cells by activating caspases-3 a...

journal_title：Cancer letters

authors： An MJ,Cheon JH,Kim SW,Kim ES,Kim TI,Kim WH

更新日期：2009-06-28 00:00:00

abstract：:These studies examined the impact of dietary corn oil and its major constituent fatty acids on the occurrence of 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary DNA adducts. In study 1, rats were fed diets containing 5, 10 or 20% corn oil for 2 weeks prior to DMBA treatment (25 mg/kg). Mammary DNA adducts increa...

journal_title：Cancer letters

authors： Schaffer EM,Milner JA

更新日期：1996-09-10 00:00:00

abstract：:The Chinese Glioma Cooperative Group (CGCG) Guideline Panel for adult diffuse gliomas provided recommendations for diagnostic and therapeutic procedures. The Panel covered all fields of expertise in neuro-oncology, i.e. neurosurgeons, neurologists, neuropathologists, neuroradiologists, radiation and medical oncologist...

journal_title：Cancer letters

authors： Jiang T,Mao Y,Ma W,Mao Q,You Y,Yang X,Jiang C,Kang C,Li X,Chen L,Qiu X,Wang W,Li W,Yao Y,Li S,Li S,Wu A,Sai K,Bai H,Li G,Chen B,Yao K,Wei X,Liu X,Zhang Z,Dai Y,Lv S,Wang L,Lin Z,Dong J,Xu G,M

更新日期：2016-06-01 00:00:00

abstract：:D-501036 is a promising anti-cancer compound that exhibits potent anti-proliferative activity against various types of human cancers through the induction of double strand DNA breaks. To determine drug resistance mechanism related to this class of DNA-damaging agents, a KB-derived D-501036-resistant cell line (S4) was...

journal_title：Cancer letters

authors： Yang YN,Chou KM,Pan WY,Chen YW,Tsou TC,Yeh SC,Cheung CH,Chen LT,Chang JY

更新日期：2011-10-01 00:00:00